Structure of PDB 7sn8 Chain K Binding Site BS01

Receptor Information
>7sn8 Chain K (length=588) Species: 7227 (Drosophila melanogaster) [Search protein sequence] [Download receptor structure] [Download structure with residue number starting from 1] [View receptor structure]
PDIKITPLGAGQDVGRSCLLLSMGGKNIMLDCGMHMGYNDERRFPDFSYI
VPEGPITSHIDCVIISHFHLDHCGALPYMSEIVGYTGPIYMTHPTKAIAP
ILLEDMRKVAVERFFTTQMIKDCMKKVIPVTLHQSMMVDTDLEIKAYYAG
HVLGAAMFWIKVGSQSVVYTGDYNMTPDRHLGAAWIDKCRPDLLISESTY
ATTIRDSKRCRERDFLKKVHECVAKGGKVLIPVFALGRAQELCILLETYW
ERMNLKYPIYFALEKANTYYKMFITWTNQKIRKTFVHRNMFDFKHIKPFD
KAYIDNPGAMVVFATPGMLHAGLSLQIFKKWAPNENNMVIMPGYCVQGTV
GNKILGGAKKVEFENRQVVEVKMAVEYMSFSAHADAKGIMQLIQNCEPKN
VMLVHGEAGKMKFLRSKIKDEFNLETYMPANGETCVISTPVKIPVDASVS
LLKAEARSYNAQPPDPKRRRLIHGVLVMKDNRIMLQNLTDALKEIGINRH
VMRFTSKVKMDDSGPVIRTSERLKTLLEEKLAGWTVTMQENGSIAIESVE
VKVEEDEKDPKQKNILISWTNQDEDIGAYILNVLQNMC
Ligand information
Ligand IDZN
InChIInChI=1S/Zn/q+2
InChIKeyPTFCDOFLOPIGGS-UHFFFAOYSA-N
SMILES
SoftwareSMILES
CACTVS 3.341[Zn++]
ACDLabs 10.04
OpenEye OEToolkits 1.5.0		[Zn+2]
FormulaZn
NameZINC ION
ChEMBLCHEMBL1236970
DrugBankDB14532
ZINC
PDB chain7sn8 Chain K Residue 800 [Download ligand structure] [Download structure with residue number starting from 1] [View ligand structure]
Receptor-Ligand Complex Structure
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PDB7sn8 Inositol hexakisphosphate is required for Integrator function.
Resolution2.74 Å
Binding residue
(original residue number in PDB)		H68 H70 H157
Binding residue
(residue number reindexed from 1)		H67 H69 H151
Annotation score4
Enzymatic activity
Enzyme Commision number 3.1.27.-
Gene Ontology
Molecular Function
GO:0004521 RNA endonuclease activity
GO:0005515 protein binding
GO:0016787 hydrolase activity
Biological Process
GO:0016180 snRNA processing
GO:0031123 RNA 3'-end processing
GO:0034472 snRNA 3'-end processing
Cellular Component
GO:0005634 nucleus
GO:0005737 cytoplasm
GO:0005829 cytosol
GO:0032039 integrator complex

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Molecular Function
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Biological Process
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Cellular Component
External links
PDB RCSB:7sn8, PDBe:7sn8, PDBj:7sn8
PDBsum7sn8
PubMed36180473
UniProtQ9VAH9|INT11_DROME Integrator complex subunit 11 (Gene Name=IntS11)

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