Structure of PDB 7scy Chain K Binding Site BS01

Receptor Information
>7scy Chain K (length=96) Species: 9606 (Homo sapiens) [Search protein sequence] [Download receptor structure] [Download structure with residue number starting from 1] [View receptor structure]
DKPLSNMKILTLGKLSRNKDEVKAMIEKLGGKLTGTANKASLCISTKKEV
EKMNKKMEEVKEANIRVVSEDFLQDVSASTKSLQELFLAHILSPWG
Ligand information
>7scy Chain J (length=147) [Search DNA sequence] [Download ligand structure] [Download structure with residue number starting from 1] [View ligand structure]
atcgagaatcccggtgccgaggccgctcaattggtcgtagacagctctag
caccgcttaaacgcacgtacgcgctgtcccccgcgttttaaccgccaagg
ggattactccctagtctccaggcacgtgtcagatatatacatccgat
Receptor-Ligand Complex Structure
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PDB7scy The BRCT domain of PARP1 binds intact DNA and mediates intrastrand transfer.
Resolution4.1 Å
Binding residue
(original residue number in PDB)		K405 T420 G421 T422 K425
Binding residue
(residue number reindexed from 1)		K19 T34 G35 T36 K39
Enzymatic activity
Enzyme Commision number 2.4.2.-
2.4.2.30: NAD(+) ADP-ribosyltransferase.
External links
PDB RCSB:7scy, PDBe:7scy, PDBj:7scy
PDBsum7scy
PubMed34919819
UniProtP09874|PARP1_HUMAN Poly [ADP-ribose] polymerase 1 (Gene Name=PARP1)

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