Structure of PDB 7pfo Chain K Binding Site BS01

Receptor Information
>7pfo Chain K (length=636) Species: 9606 (Homo sapiens) [Search protein sequence] [Download receptor structure] [Download structure with residue number starting from 1] [View receptor structure]
NCELLATCSALGYLEGDTYHKEPDCLESVKDLIRYLRHEDETRDVRQQLG
AAQILQSDLLPILTQHHQDKPLFDAVIRLMVNLTQPALLCFGNLPKEPSF
RHHFLQVLTYLQAYKEAFASEKAFGVLSETLYELLQLGRQEEDNLLIERI
LLLVRNILHVPADLDQEKKIDDDASAHDQLLWAIHLSGLDDLLLFLASSS
AEEQWSLHVLEIVSLMFRDQNPEQLAGVGQGRLAQERSADFAELEVLRQR
EMAEKKTRALQRGNRHSRFGGSYIVQGLKSIGERDLIFHKGLHNLRNYSS
DLGKQPKKVPKRRQAARELSIQRRSALNVRLFLRDFCSEFLENCYNRLMG
SVKDHLLREKAQQHDETYYMWALAFFMAFNRAASFRPGLVSETLSVRTFH
FIEQNLTNYYEMMLTDRKEAASWARRMHLALKAYQELLATVNEMDISPDE
AVRESSRIIKNNIFYVMEYRELFLALFRKFDERCQPRSFLRDLVETTHLF
LKMLERFCRSRGNLVVQSEKEFNFLDYLKRFACSTVVRAYVLLLRSYQQN
SAHTNHCIVKMLHRLAHDLKMEALLFQLSVFCLFNRLLSDPAAGAYKELV
TFAKYILGKFFALAAVNQKAFVELLFWKNTAVVREM
Ligand information
Receptor-Ligand Complex Structure
Global viewLocal viewStructure summary

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PDB7pfo Structure of a human replisome shows the organisation and interactions of a DNA replication machine.
Resolution3.2 Å
Binding residue
(original residue number in PDB)		R321 R426 R492
Binding residue
(residue number reindexed from 1)		R312 R417 R483
Enzymatic activity
Enzyme Commision number ?
Gene Ontology
Molecular Function
GO:0003677 DNA binding
GO:0005515 protein binding
GO:0042802 identical protein binding
Biological Process
GO:0000076 DNA replication checkpoint signaling
GO:0002009 morphogenesis of an epithelium
GO:0006281 DNA repair
GO:0006974 DNA damage response
GO:0007623 circadian rhythm
GO:0009582 detection of abiotic stimulus
GO:0030324 lung development
GO:0042127 regulation of cell population proliferation
GO:0042752 regulation of circadian rhythm
GO:0043111 replication fork arrest
GO:0044770 cell cycle phase transition
GO:0045892 negative regulation of DNA-templated transcription
GO:0048511 rhythmic process
GO:0048754 branching morphogenesis of an epithelial tube
GO:0051301 cell division
GO:0072711 cellular response to hydroxyurea
GO:0072719 cellular response to cisplatin
GO:1904976 cellular response to bleomycin
GO:1905168 positive regulation of double-strand break repair via homologous recombination
GO:2000781 positive regulation of double-strand break repair
Cellular Component
GO:0000785 chromatin
GO:0005634 nucleus
GO:0005654 nucleoplasm
GO:0005694 chromosome
GO:0031298 replication fork protection complex
GO:0035861 site of double-strand break

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Molecular Function
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Biological Process
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Cellular Component
External links
PDB RCSB:7pfo, PDBe:7pfo, PDBj:7pfo
PDBsum7pfo
PubMed34694004
UniProtQ9UNS1|TIM_HUMAN Protein timeless homolog (Gene Name=TIMELESS)

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