Structure of PDB 7p7u Chain K Binding Site BS01

Receptor Information

>7p7u Chain K (length=174) Species: 1351 (Enterococcus faecalis)

SRIGNKVVVLPAGVEIKQDGNNITVKGPKGELTREFSSDIKMNIEGNEVT
FIRPNDSKEMKTIHGTTRANFNNMVVGVSEGFQKALELIGVGYRAQVQGN
KLTLNVGYSHPVEMTAPEGVTFEVPANTQVIVKGINKEVVGELAANIRGV
RPPEPYKGKGIRYVGEFVRRKEGK

Ligand information

>7p7u Chain A (length=2824)

uuaagugaauaagggcgcacgguggaugccuuggcacuaggagccgauga
aggacgggacuaacaccgauaugcuuuggggagcuguaaguaagcuauga
uccagagauuuccgaaugggggaacccaauaucuuuuauaggauauuacu
uuucagugaauacauagcugauuagagguagacgcagagaacugaaacau
cuuaguaccugcaggaagagaaagaaaauucgauucccugaguagcggcg
agcgaaacgggaagagcccaaaccaacaagcuuguugggguuguaggacu
ccgauaugguagucuguuaguauaguugaaggauuuggaaaauuccgcua
aagagggugaaagccccguagacgaaaugcugacaacaccuaggaggauc
cugaguacggcggaacacgagaaauuccgucggaauccgcggggaccauc
ccgcaaggcuaaauacucccuagugaccgauagugaaccaguaccgugag
ggaaaggugaaaagcaccccggaaggggagugaaauagauccugaaaccg
ugugccuacaacaagucaaagcucguuaaugagugauggcgugccuuuug
uagaaugaaccggcgaguuacgauugcaugcgagguuaagucgaagagac
ggagccgcagcgaaagcgagucugaauagggcgaaugaguauguagucgu
agacccgaaaccaugugaucuacccauguccagguugaaggugcgguaaa
acgcacuggaggaccgaacccacguacguugaaaagugcggggaugaggu
guggguagcggagaaauuccaaacgaacuuggagauagcugguucucucc
gaaauagcuuuagggcuagccucggaauugagaaugauggagguagagca
cuguuuggacuaggggcccaucucggguuaccgaauucagauaaacuccg
aaugccauucauuuauauccgggagucagacugcgagugauaagauccgu
agucgaaagggaaacagcccagaccaccagcuaaggucccaaaauauaug
uuaaguggaaaaggaugugggguugcacagacaacuaggauguuggcuua
gaagcagccaccauuuaaagagugcguaauagcucacuagucgagugacc
cugcgccgaaaauguaccggggcuaaacauauuaccgaagcuguggacua
caccauuagguguagugguaggagagcguucuaagggcguugaaggucga
ucgugaggacggcuggagcgcuuagaagugagaaugccgguaugaguagc
gaaagacaggugagaauccuguccaccguaugacuaagguuuccugggga
aggcucguccgcccaggguuagucgggaccuaagccgaggccgauaggcg
uaggcgauggacaacagguugauauuccuguaccaguuguuuuuguuuga
gcaauggagggacgcaguaggcuaaggaaugcaugcgauuggaagugcau
guccaagcaaugagucuugaguagaguuaaaugcuuuacucuuuaaggac
aaguugugacggggagcgaaauaguagcgaaguuccugacgucacacugc
caagaaaagcuucuagugagaaaacaacugcccguaccguaaaccgacac
agguagucgaggagaguauccuaaggugagcgagcgaacucucguuaagg
aacucggcaaaaugaccccguaacuucgggagaaggggugcugacuucgg
ucagccgcagugaauaggcccaagcgacuguuuaucaaaaacacaggucu
cugcaaaaucguaagaugaaguauaggggcugacgccugcccggugcugg
aagguuaagaggauggguuagcuucggcgaagcucagaauugaagcccca
guaaacggcggccguaacuauaacgguccuaagguagcgaaauuccuugu
cggguaaguuccgacccgcacgaaaggcguaacgauuugggcacugucuc
aacgagagacucggugaaauuuuaguaccugugaagaugcagguuacccg
cgacaggacggaaagaccccauggagcuuuacuguaguuugauauugagu
guuuguaccuguuaugaacccucuaacccgcaccacuaaucgugguggga
gacagugucagaugggcaguuugacuggggcggucgccuccuaaaaggua
acggaggcgcccaaagguucccucagaaugguuggaaaucauucgaagag
uguaaaggcagaagggagcuugacugcgagaccuacaagucgagcaggga
cgaaagucgggcuuagugauccggugguuccgcauggaagggccaucgcu
caacggauaaaagcuacccuggggauaacaggcuuaucucccccaagagu
ccacaucgacggggagguuuggcaccucgaugucggcucgucgcauccug
gggcuguagucggucccaaggguugggcuguucgcccauuaaagcggcac
gcgagcuggguucagaacgucgugagacaguucggucccuauccgucgcg
ggcguuggaaauuugagaggagcuguccuuaguacgagaggaccgggaug
gacuuaccgcugguguaccaguuguucugccaagggcauugcuggguagc
uauguagggaagggauaaacgcugaaagcaucuaagugugaagcccaccu
caagaugagauuucccauuucuuuaagaaaguaagaccccugagagauga
ucagguagauagguuggaaguggaaggcuagugauaguuggagcggacca
auacuaaucggucgaggacuuaac

<<<<<<......<<<<<<<<<<<.....[[..[[<<<<<<<[[<<.....
.<<<<<<.((..((.>>>.....<<<<<<<..<<<))..)).>>>.....
>>>>>>>...>>>....<<<....>>><<<<<<<......>>>>>>>.<<
..<<<<<.........>>>>>..>>.>>....<<<<<......<<....>
>.......>>>>.>.........<<....>>..<<<<<......<<....
.>>.....>>>>>..(((....<<<<<<<..>>>>>>>......<<<<<<
<<.....<<<.<<.<<<<<<<<<.<<<...<<<.<......>.>>>((..
....<<<.....))>>>...>>>...>>>>>>>>>>>>>>..>>>>..>>
>>.....<<<<<<<<.........>>>>>>>>......<<<<<..<<<<>
>>>>..)))......]].>>>>>>>.]]...............<<....>
>....]].........<<<<....>>>>..................>>>>
>>>>>>>.......<<<<..<<<<......>>>>..>>>>...<.<....
....>.>.<<<<<<....<<<<<<<<<<<<<..<<<...<<<.....>>>
...>>>...<<....>>..<<<<.....>>>>......>>>>>>>>>>>>
>..<<.<..<<<<.<<.....<<<<<<<<<..<<<....<<<<<<.....
.>>>>>>.....>>>...<<<.<<<<<........>>>>>>>>....>>>
>>>>>>...<<<.....>>>......>>.>>>...>..>.>>..<<<<<<
....<<<<<....>>>>><<<<<<<<.<...<<<<<<<<<.....<<<..
.<<<<<<<<...<<<<<<<.....>>>>>.>>...>>>>>>>>..>>.>.
....>>>>.>>>>>..>>>>>>>.>>..<<<<<<<.<<......>>.>>>
>>>>....<<<......>>>...<<<<.<<<...<<<(((.....<<<<<
<...........<<..<<<<<<<<<........<<<<<.<<...<<<<..
.....>>>>...>>.........<<......>>...>>>>>....>>>>>
>>>>.>>...........))).....>>>>>>.>>>...>>>>>>><<<<
<<<<....>>>>>>>>....>>>>>>..<<<<<<<.<<......<<<<<.
<<....>>.>>>>>...>>.>>>>>>>........>>>>>><......<<
....<<<<<<.......>>>>>><<<<....<<<<<.<<<..<<<<<<..
.<<.....>>.>>>>>>....((<<<<.<<...<<<...<<<....>>>.
..>>>...>>...<<<<<........>>>>>))<<<<<<<<<<<......
<<...<<<<....<<<<..<<...<<<<<.<<<<<<...(((....>>>>
>><<..<<<<<..<<<<.<<<<<<<<<.....>>>>>>>>>.....>>>>
..>>>>>...>>...<<.........>>....>>>>>....>>...>>>>
.........>>>>..>>..>>>>>>>>>>>>>>>.>>>.....<<.....
.>>>>>>>.<<<<.....>>>>..>>>>..<<<<....<<<<<<<<.<<.
..............<<<<<...............>>>>><<<<<<....>
>>>>>............<<<<<<<<<..<<<.........>>>..<<<<<
<<.....<<<....>>>.......>>>>>>>.<<<<<.<<<..<<<<<<<
..<<<...<<...<<<<<<.<<....>>..>>>>>>...>>...>>>>>>
>>..>>>>><<<<<<.......>>>>>>........<...........<<
<<<<.....>>>>>>.....>....>>>>>..>>.>>>>>>>.....>>.
>>>>>>>>.>>>>>>.....>.....<<<<<........>>>>>..<<<<
<<<<.(((.[[......<<<<.[[<<<<..<<<<<.<<<<<<<<<.<<<.
<<<<<<<.....>>>>>>>.>>>....<<.<<<<<<.....>>>>>>>>.
....>>>>>>>>>..>>>>>..<<<<.....>>>><<<<<<.........
..>>>>>>..<<...<<<<<<<...<<<<<<.......>>>>>>.....<
<.[.(((>>....>>>>>>>...<<<<..<<<......>>>..>>>>.<<
<....>>>.>>)))]......<<<<<<<.((..>>>>..))>>>>>>>..
...........>>>>..]]>>>>.......<<<<...<<<<<<...<<..
.....>>...>>>>>>....>>>.>.......<<<<<.<<<<<<..<<<<
<<<<<......>>>>>>>..>>.<<<<<.....>>>>>.....>>>>>..
>...>>>.>>....<<<<<<<....>>>.>>>>....]]..)))>>>>>>
>>....<<<<<<<...<<<<..<<<<<<<...............>>>>>>
>.<<<<<...<<<<...<<<<<<<<<<<.)))>>>>>>..>>>>>...>>
>>.>>>>>...<<<....<<<<<...........>>>>>....>>>.>>>
>.......>>>>>>>..<<<<.....>>>>....<<<<<<<<<.......
>>>>>....<<<<<<<<..<<.....<<<<....>>>>....>>...>>>
>>.>>>...>>>>....>>>>>>.

Receptor-Ligand Complex Structure

Structure summary

• PDB: 7p7u Structural basis for PoxtA-mediated resistance to phenicol and oxazolidinone antibiotics.
• Resolution: 3.1 Å
• Binding residue (original residue number in PDB): S2 I4 K59 T63 G66 T67 A70 N74 G108 Y109 S110 H111 K138 E139 G142 E143 Y157 K158 K160 K172
• Binding residue (residue number reindexed from 1): S1 I3 K58 T62 G65 T66 A69 N73 G107 Y108 S109 H110 K137 E138 G141 E142 Y156 K157 K159 K171

Gene Ontology

Molecular Function

• GO:0003735 structural constituent of ribosome
• GO:0019843 rRNA binding

Biological Process

• GO:0002181 cytoplasmic translation
• GO:0006412 translation

Cellular Component

• GO:0005840 ribosome
• GO:0022625 cytosolic large ribosomal subunit
• GO:1990904 ribonucleoprotein complex

External links

• PDB: RCSB:7p7u, PDBe:7p7u, PDBj:7p7u
• PDBsum: 7p7u
• PubMed: 35387982
• UniProt: Q839E9|RL6_ENTFA Large ribosomal subunit protein uL6 (Gene Name=rplF)