Structure of PDB 7lps Chain K Binding Site BS01

Receptor Information
>7lps Chain K (length=381) Species: 9606 (Homo sapiens) [Search protein sequence] [Download receptor structure] [Download structure with residue number starting from 1] [View receptor structure]
INFDTSLPTSHTYLGADMEEFHGRTLHDDDSCQVIPVLPQVMMILIPGQT
LPLQLFHPQEVSMVRNLIQKDRTFAVLAYSNVQEREAQFGTTAEIYAYRE
EQDFGIEIVKVKAIGRQRFKVLELRTQSDGIQQAKVQILPECVLPSTMSA
VQLESLNKCQIFPCSYKWWQKYQKRKFHCANLTSWPRWLYSLYDAETLMD
RIKKQLREWDENLKDDSLPSNPIDFSYRVAACLPIDDVLRIQLLKIGSAI
QRLRCELDIMNKCTSLCCKQCQETEITTKNEIFSLSLCGPMAAYVNPHGY
VHETLTVYKACNLNLIGRPSTEHSWFPGYAWTVAQCKICASHIGWKFTAT
KKDMSPQKFWGLTRSALLPTIPDTEDEISPD
Ligand information
>7lps Chain L (length=28) Species: 9606 (Homo sapiens) [Search peptide sequence] [Download ligand structure] [Download structure with residue number starting from 1] [View ligand structure]
ERPFHCNQCGASFTQKGNLLRHIKLHSG
Receptor-Ligand Complex Structure
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PDB7lps Acute pharmacological degradation of Helios destabilizes regulatory T cells.
Resolution3.78 Å
Binding residue
(original residue number in PDB)		N351 H353 Y355 W386 V388 Q390 A395 H397
Binding residue
(residue number reindexed from 1)		N296 H298 Y300 W331 V333 Q335 A340 H342
Enzymatic activity
Enzyme Commision number ?
External links
PDB RCSB:7lps, PDBe:7lps, PDBj:7lps
PDBsum7lps
PubMed34035522
UniProtQ96SW2|CRBN_HUMAN Protein cereblon (Gene Name=CRBN)

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