Structure of PDB 7kd6 Chain K Binding Site BS01
Receptor Information
>7kd6 Chain K (length=282) Species:
9606
(Homo sapiens) [
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GEVCPGMDIRNNLTRLHELENCSVIEGHLQILLMFKTRPEDFRDLSFPKL
IMITDYLLLFRVYGLESLKDLFPNLTVIRGSRLFFNYALVIFEMVHLKEL
GLYNLMNITRGSVRIEKNNELCYLATIDWSRILDSVEDNHIVLNKDDNEE
CGDICNCPATVFVERCWTHSHCQKVCPTICKSHGCTAEGLCCHSECLGNC
SQPDDPTKCVACRNFYLDGRCVETCPPPYYHFQDWRCVNFSFCQDLHHKC
KNCHQYVIHNNKCIPECPSGYTMNSSNLLCTP
Ligand information
>7kd6 Chain L (length=15) Species:
9606
(Homo sapiens) [
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TFEDYLHNVVFVPRP
Receptor-Ligand Complex Structure
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PDB
7kd6
Single-chain insulin analogs threaded by the insulin receptor alpha CT domain.
Resolution
2.6 Å
Binding residue
(original residue number in PDB)
L36 L37 F64 F88 F89 F96 R118 K121
Binding residue
(residue number reindexed from 1)
L32 L33 F60 F84 F85 F92 R114 K117
Enzymatic activity
Enzyme Commision number
2.7.10.1
: receptor protein-tyrosine kinase.
External links
PDB
RCSB:7kd6
,
PDBe:7kd6
,
PDBj:7kd6
PDBsum
7kd6
PubMed
36181268
UniProt
P06213
|INSR_HUMAN Insulin receptor (Gene Name=INSR)
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