Structure of PDB 7enn Chain K Binding Site BS01

Receptor Information
>7enn Chain K (length=539) Species: 9606 (Homo sapiens) [Search protein sequence] [Download receptor structure] [Download structure with residue number starting from 1] [View receptor structure]
AARVQEQDLRQWGLTGIHLRSYQLEGVNWLAQRFHCQNGCILGDEMGLGK
TCQTIALFIYLAGRLNDEGPFLILCPLSVLSNWKEEMQRFAPGLSCVTYA
GDKEERACLQQDLKQESRFHVLLTTYEICLKDASFLKSFPWSVLVVDEAH
RLKNQSSLLHKTLSEFSVVFSLLLTGTPIQNSLQELYSLLSFVEPDLFSK
EEVGDFIQRYQDIEKESESASELHKLLQPFLLRRVKAEVATELPKKTEVV
IYHGMSALQKKYYKAILMKKLQNILSQLRKCVDHPYLFDGVEPEPFEVGD
HLTEASGKLHLLDKLLAFLYSGGHRVLLFSQMTQMLDILQDYMDYRGYSY
ERVDGSVRGEERHLAIKNFGQQPIFVFLLSTRAGGVGMNLTAADTVIFVD
SDFNPQNDLQAAARAHRIGQNKSVKVIRLIGRDTVEEIVYRKAASKLQLT
NMIIEGGHFEILKFGLDKLLASEGSTMDEIDLESILGETKDGQWVSDAEG
KNHMYLFEGKDYSKEPSKEDRKSFEQLVNLQGRSLRNKG
Ligand information
>7enn Chain I (length=146) [Search DNA sequence] [Download ligand structure] [Download structure with residue number starting from 1] [View ligand structure]
tggagaatcccggtgccgaggccgctcaattggtcgtagacagctctagc
accgcttaaacgcacgtacgcgctgtcccccgcgttttaaccgccaaggg
gattactccctagtctccaggcacgtgtcagatatatacatcctga
Receptor-Ligand Complex Structure
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PDB7enn Structural basis of ALC1/CHD1L autoinhibition and the mechanism of activation by the nucleosome.
Resolution2.8 Å
Binding residue
(original residue number in PDB)		R178 S184 L185 N444
Binding residue
(residue number reindexed from 1)		R151 S157 L158 N404
Enzymatic activity
Enzyme Commision number 3.6.4.-
Gene Ontology
Molecular Function
GO:0000166 nucleotide binding
GO:0003678 DNA helicase activity
GO:0005515 protein binding
GO:0005524 ATP binding
GO:0016787 hydrolase activity
GO:0016887 ATP hydrolysis activity
GO:0031491 nucleosome binding
GO:0140566 histone reader activity
GO:0140658 ATP-dependent chromatin remodeler activity
GO:0160004 poly-ADP-D-ribose modification-dependent protein binding
Biological Process
GO:0006281 DNA repair
GO:0006338 chromatin remodeling
GO:0006974 DNA damage response
GO:0032508 DNA duplex unwinding
Cellular Component
GO:0005634 nucleus
GO:0005654 nucleoplasm
GO:0005694 chromosome
GO:0005829 cytosol
GO:0005886 plasma membrane
GO:0035861 site of double-strand break

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Molecular Function
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Biological Process
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Cellular Component
External links
PDB RCSB:7enn, PDBe:7enn, PDBj:7enn
PDBsum7enn
PubMed34210977
UniProtQ86WJ1|CHD1L_HUMAN Chromodomain-helicase-DNA-binding protein 1-like (Gene Name=CHD1L)

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