Structure of PDB 6x35 Chain K Binding Site BS01

Receptor Information
>6x35 Chain K (length=3801) Species: 9823 (Sus scrofa) [Search protein sequence] [Download receptor structure] [Download structure with residue number starting from 1] [View receptor structure]
QFLRTDDEVVLQCNATVLKEQLKLCLAAEGFGNRLCFLEPTSNAQNVPPD
LAICCFVLEQSLSVRALQEMLANGHRTLLYGHAILLRHAHSGMYLSCLTT
SRSMTDKLAFDVGLQEDATGEACWWTTHPASKQRSEGEKVRVGDDLILVS
VSSERYLHLSTASGELQVDASFMQTLWNMNPICSGCEEGYVTGGHVLRLF
HGHMDECLTISPADQRRLVYYEGGSVCTHARSLWRLEPLRISWSGSHLRW
GQPLRIRHVTTGRYLALIEDQGLVVVDASKAHTKATSFCFRISKEKLKRD
VEGMGPPEIKYGESLCFVQHVASGLWLTYAALKKKAILHQEGHMDDALSL
TRCQQEESQAARMIYSTAGLYNHFIKGLDSFSGKPRPAGTALPLEGVILS
LQDLIGYFEPPSEELQHEEKQSKLRSLRNRQSLFQEEGMLSLVLNCIDRL
NVYTTAAHFAEFAGEEAAESWKEIVNLLYEILASLIRGNRANCALFSNNL
DWLVSKLDRLEASSGILEVLYCVLIESPEVLNIIQENHIKSIISLLDKHG
RNHKVLDVLCSLCVCNGVAVCSNQDLITENLLPGRELLLQTNLINYVTSI
RPNIFVGRAEGTTQYSKWYFEVMVDEVVPFLTAQATHLRVGWALTEGYSP
YPGGGEGWGGNGVGDDLYSYGFDGLHLWTGHVPRLVTSPGQHLLAPEDVV
SCCLDLSVPSISFRINGCPVQGVFEAFNLNGLFFPVVSFSAGVKVRFLLG
GRHGEFKFLPPPGYAPCHEAVLPRERLRLEPIKEYRREGPRGPHLVGPSR
CLSHTDFVPCPLPPHLERIREKLAENIHELWALTRIEQGWTYGPVRDDNK
RLHPCLVDFHSLPEPERNYNLQMSGETLKTLLALGCHVGMADEKAEDNLR
KTKLPKTYMMSNGYKPAPLDLSHVRLTPAQTTLVDRLAENGHNVWARDRV
AQGWSYSAVQDIPARRNPRLVPYRLLDEATKRSNRDSLCQAVRTLLGYGR
VRIFRAEKSYAVQSGRWYFEFEAVTTGEMRVGWARPELRPDVELGADELA
YVFNGHRGQRWHLGSELFGRPWQSGDVVGCMIDLTENTIIFTLNGEVLMS
DSGSETAFRDIEVGDGFLPVCSLGPGQVGHLNLGQDVSSLRFFAICGLQE
GFEPFAINMQRPVTTWFSKSLPQFEAVPLEHPHYEVSRVDGTVDTPPCLR
LTHRSLVEMLFLRLSLPVQFHQLNTTTYYYSVRVFAGQEPSCVWVGWVTP
DYHQHDMNFDLTKVRAVTVTMGDNIHSSLKCSNCYMVWGGDFVSHTDLVI
GCLVDLATGLMTFTANGKESNTFFQVEPNTKLFPAVFVLPTHQNVIQFEL
GKQKNIMPLSAAMFLSERKNPAPQCPPRLEMQMLMPVSWSRMPNHFLRVE
TRRAGERLGWAVQCQEPLTMMALHIPEENRCMDILELSERLDLQQFHSHT
LRLYRAVCALGNNRVAHALCSHVDQAQLLHALEDAHLPGPLRAGYYDLLI
SIHLESACRSRRSMLSEYIVPLTPETRAITLFPPRHGLPGVGVTTSLRPP
HHFSAPCFVAALPEAPARLSPSIPLEALRDKALRMLGEAVRDGGQHARDP
VGGSVEFQFVPVLKLVSTLLVMGIFGDEDVKQILKMIEPEVEEGLLQMKL
PESVKLQMCNLLEYFCDQELQHRVESLAAFAERYVDKLQANQRDRYGILM
KAFTMTAAETARRTREFRSPPQEQINMLLHFKPLPDEIRQDLLEFHQDLL
THCGIQLQSLQELVSHTVVRWAQEDFVQSPELVRAMFSLLHRQYDGLGEL
LRALPRAYTISPSSVEDTMSLLECLGQIRSLLIVQMGPQEENLMIQSIGN
IMNNKVFYQHPNLMRALGMHETVMEVMVNVLGRFPKMVTSCCRFLCYFCR
ISRQNQRSMFDHLSYLLENSGSTPLDVAAASVIDNNELALALQEQDLEKV
VSYLAGCGLQSCPMLLAKGYPDIGWNPCGGERYLDFLRFAVFVNGESVEE
NANVVVRLLIRKPECFGPALRLLATIEEAIGHAIMSFYAALIDLLGRCAP
EMHLIQAGKGEALRIRAILRSLVPLDDLVGIISLPLQIPLMSASFVPDHK
ASMVLFLDRVYGIEFLLHVLDVGFEMALALNRYLCLAVLPLITKCAPLFA
MVDSMLHTVYRLSRGRSLTKAQRDVIEECLMALCRYIRPSMLQHLLRRLV
FAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAADPR
PVETLNVIIPEKLDSFINKFAEYTHEKWAFDKIQNNWSYGENIDEELKTH
PMLRPYKTFSEKDKEIYRWPIKESLKAMIAWEWTIEKAREGEYNPQPPDL
SGVTLSRELQAMAEQLAENYHNTWGRKKKQELEAKGGGTHPLLVPYDTLT
AKEKARDREKAQELLKFLQMNGYAVTRAAAAAAAAAAAAAAAAAAAAAAA
AAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAA
AAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAA
AAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAA
AAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAEFS
VLCRDLYALYPLLIRYVDNNRAHWLTEPNPSAEELFRMVGEIFIYWSKSH
NFKREEQNFVVAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAA
AAAAAAAAAAAAAAAAAAAAAAAAAAAAARRAVVACFRMTPLYNLPTHRA
CNMFLESYKAAWILTEDHSFEDRMIDDLSKAGEQEEEEEEVEEKKPDPLH
QLVLHFSRTALTEKSKLDEDYLYMAYADIMAKSCHLEESFEEKEMEKQRL
LYQQARLHNRGAAEMVLQMISACKGETGAMVSSTLKLGISILNGGNADVQ
QKMLDYLKDKKEVGFFQSIQALMQTCSVLDLNAFERQNKAEGLGMVNEDG
TVIGEKVMADDEFTQDLFRFLQLLCEGHNNDFQNYLRTQTGNTTTINIII
CTVDYLLRLQESISDFYWYYSGKDVIEEQGKRNFSKAMSVAKQVFNSLTE
YIQGPCTGNQQSLAHSRLWDAVVGFLHVFAHMMMKLAQDSSQIELLKELL
DLQKDMVVMLLSLLEGNVVNGMIARQMVDMLVESSSNVEMILKFFDMFLK
LKDIVGSEAFQDYVTDPRGLISKKDFQKAAAAAAEEFANRFQEPARDIGF
NVAVLLTNLSEHVPHDPRLRNFLELAESILEYFRPYLGRIEIMGASRRIE
RIYFEISETNRAQWEMPQVKESKRQFIFDVVNEGGESEKMELFVSFCEDT
IFEMQAAAAAAAAAAAAAAAAAEVQRVKFLNYLSRNFYTLRFLALFLAFA
INFILLFYKVSDSPPVYYFLEESTGYMEPALRCLSLLHTLVAFLCIIGYN
CLKVPLVIFKREKELARKLEFDGLYITEQPEDDDVKGQWDRLVLNTPSFP
SNYWDKFVKRKVLDKHGDIYGRERIAEGLLTWLMSIDVKYQIWKFGVIFT
DNSFLYLGWYMVMSLLGHYNNFFFAAHLLDIAMGVKTLRTILSSVTHNGK
QLVMTVGLLAVVVYLYTVVAFNFFRKFYNKSEDEDEPDMKCDDMMTCYLF
HMYVGVRAGGGIGDEIEDPAGDEYELYRVVFDITFFFFVIVILLAIIQGL
IIDAFGELRDQQEQVREDMETKCFICGIGSDYFDTTPHRFETHTLEEHNL
ANYMFFLMYLINKDETEHTGQESYVWKMYQERCWDFFPAGDCFRKQYEDQ
L
Ligand information
Ligand IDZN
InChIInChI=1S/Zn/q+2
InChIKeyPTFCDOFLOPIGGS-UHFFFAOYSA-N
SMILES
SoftwareSMILES
CACTVS 3.341[Zn++]
ACDLabs 10.04
OpenEye OEToolkits 1.5.0		[Zn+2]
FormulaZn
NameZINC ION
ChEMBLCHEMBL1236970
DrugBankDB14532
ZINC
PDB chain6x35 Chain K Residue 5101 [Download ligand structure] [Download structure with residue number starting from 1] [View ligand structure]
Receptor-Ligand Complex Structure
Global viewLocal viewStructure summary

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PDB6x35 Pathological conformations of disease mutant Ryanodine Receptors revealed by cryo-EM.
Resolution4.2 Å
Binding residue
(original residue number in PDB)		H4976 H4981
Binding residue
(residue number reindexed from 1)		H3743 H3748
Annotation score1
Gene Ontology
--> -->
 
 
UnboundLocalError		Python 3.6.8: /usr/bin/python3
Sun Dec 1 17:08:10 2024

A problem occurred in a Python script. Here is the sequence of function calls leading up to the error, in the order they occurred.

 /var/www/html/BioLiP/pdb.cgi in <module>()
   1435     title=pdb2title(pdbid)
   1436     if bs.startswith("BS"):
=> 1437         pubmed,uniprot=display_interaction(pdbid,asym_id,bs,title)
   1438     else:
   1439         if lig3:
pubmed = '', uniprot = '', display_interaction = <function display_interaction>, pdbid = '6x35', asym_id = 'K', bs = 'BS01', title = 'Pathological conformations of disease mutant Ryanodine Receptors revealed by cryo-EM.'
 /var/www/html/BioLiP/pdb.cgi in display_interaction(pdbid='6x35', asym_id='K', bs='BS01', title='Pathological conformations of disease mutant Ryanodine Receptors revealed by cryo-EM.')
   1295         display_ec(ec,csaOrig,csaRenu)
   1296     if go:
=> 1297         display_go(go,uniprot,pdbid,asym_id)
   1298     return pubmed,uniprot
   1299 
global display_go = <function display_go>, go = '0005216,0005219,0005262,0006811,0006816,0006874,0016020,0055085,0070588', uniprot = '', pdbid = '6x35', asym_id = 'K'
 /var/www/html/BioLiP/pdb.cgi in display_go(go='0005216,0005219,0005262,0006811,0006816,0006874,0016020,0055085,0070588', uniprot='', pdbid='6x35', asym_id='K')
    480         '''.replace("$namespace_link",namespace_link
    481           ).replace("$namespace",namespace
=>  482           ).replace("$uniprot",u
    483         ))
    484         for l,(term,name) in enumerate(go2aspect[Aspect]):
u undefined

UnboundLocalError: local variable 'u' referenced before assignment
      args = ("local variable 'u' referenced before assignment",)
      with_traceback = <built-in method with_traceback of UnboundLocalError object>