Structure of PDB 6wvv Chain K Binding Site BS01

Receptor Information
>6wvv Chain K (length=440) Species: 5855 (Plasmodium vivax) [Search protein sequence] [Download receptor structure] [Download structure with residue number starting from 1] [View receptor structure]
TTVPQVVSLDPTTIPIDYHTPIDDLSIEVGLIVFLLNSTGKLGTSKGCGP
ANEETELEIRKVAYALVTLKKVSIIFEIKIEEALFRFFLEHLFYEYVTDE
RFKSFIKNLSLHIANADAYKGQIDKARVYFYGTYYAAQLIAAPSNYCNPV
SLSNAAVELAQKVNLECKILDVKELEELKMGAYLSVGKGSMYPNKFIHLT
YKGAKKIALIGKGITFDSGGYNLKAAPGSMIDLMKFDMSGCAAVLGCAYC
IGTIKPDNVEVHFLSAVCENMVSKNSYRPGDIITASNGKTIEVGNTDAEG
RLTLADALVYAEKLGVDYIVDIATLTGAMLYSLGTSYAGVFGNNDQLINK
ILSSSKTSNEPVWWLPIINEYRSSLNSKYADLNNISSSVKASSVVASLFL
KEFIENTPWAHIDIAGVSWNFKARKPKGFGVRLLTEFVLN
Ligand information
Ligand IDZN
InChIInChI=1S/Zn/q+2
InChIKeyPTFCDOFLOPIGGS-UHFFFAOYSA-N
SMILES
SoftwareSMILES
CACTVS 3.341[Zn++]
ACDLabs 10.04
OpenEye OEToolkits 1.5.0		[Zn+2]
FormulaZn
NameZINC ION
ChEMBLCHEMBL1236970
DrugBankDB14532
ZINC
PDB chain6wvv Chain K Residue 701 [Download ligand structure] [Download structure with residue number starting from 1] [View ligand structure]
Receptor-Ligand Complex Structure
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PDB6wvv Active site metals mediate an oligomeric equilibrium in Plasmodium M17 aminopeptidases.
Resolution2.33 Å
Binding residue
(original residue number in PDB)		K390 D395 D415 E477
Binding residue
(residue number reindexed from 1)		K212 D217 D237 E299
Annotation score1
Enzymatic activity
Enzyme Commision number 3.4.11.1: leucyl aminopeptidase.
3.4.13.-
Gene Ontology
Molecular Function
GO:0030145 manganese ion binding
GO:0046872 metal ion binding
GO:0070006 metalloaminopeptidase activity
Biological Process
GO:0006508 proteolysis
GO:0019538 protein metabolic process
Cellular Component
GO:0005737 cytoplasm

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Molecular Function
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Biological Process
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Cellular Component
External links
PDB RCSB:6wvv, PDBe:6wvv, PDBj:6wvv
PDBsum6wvv
PubMed33303633
UniProtA5K3U9|AMPL_PLAVS Leucine aminopeptidase (Gene Name=LAP)

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