Structure of PDB 6wru Chain K Binding Site BS01

Receptor Information
>6wru Chain K (length=58) Species: 1280 (Staphylococcus aureus) [Search protein sequence] [Download receptor structure] [Download structure with residue number starting from 1] [View receptor structure]
KEIRNLTTSEIEEQIKSSKEELFNLRFQLATGQLEETARIRTVRKTIARL
KTVARERE
Ligand information
>6wru Chain 1 (length=2665) [Search RNA sequence] [Download ligand structure] [Download structure with residue number starting from 1] [View ligand structure]
uaaguuauuaagggcgcacgguggaugccuuggcacuagaagccgaugaa
ggacguuacuaacgacgauaugcuuuggggagcuguaaguaagcuuugau
ccagagauuuccgaauggggaaacccagcaugaguuaugucauguuaucg
auaugugaauacauagcauaucagaaggcacacccggagaacugaaacau
cuuaguacccggaggaagagaaagaaaauucgauucccuuaguagcggcg
agcgaaacgggaagagcccaaaccaacaagcuugcuuguugggguuguag
gacacucuaguuacaaaggacgacauuagacgaaucaucuggaaagauga
aucaaagaagguaauaauccuguagucgaaaauguugucucucuugagug
gauccugaguacgacggagcacgugaaauuccgucggaaucugggaggac
caucuccuaaggcuaaauacucucuagugaccgauagugaaccaguaccg
ugagggaaaggugaaaagcaccccggaaggggagugaaauagaaccugaa
accgugugcuuacaaguagucagagcccguuaaugggugauggcgugccu
uuuguagaaugaaccggcgaguuacgauuugaugcaagguuaagcaguaa
auguggagccguagcgaaagcgagucugaauagggcguuuaguauuuggu
cguagacccgaaaccaggugaucuacccuuggucagguugaaguucaggu
aacacugaauggaggaccgaaccgacuuacguugaaaagugagcggauga
acugaggguagcggagaaauuccaaucgaaccuggagauagcugguucuc
uccgaaauagcuuuagggcuagccucaagugaugauuauuggagguagag
cacuguuuggacucagacaaacuccgaaugccaauuaauuuaacuuggga
gucagaacaugggugauaagguccguguucgaaagggaaacagcccagac
caccagcuaaggucccaaaauauauguuaaguggaaaaggauguggcguu
gccgugacacugcgccgaaaauguaccggggcuaaacauauuaccgaagc
uguggauuguccuuuggacaaugguaggagagcguucuaagggcguugaa
gcaugaucguaaggacauguggagcgcuuagaagugagaaugccggugug
aguagcgaaagacgggugagaaucccguccaccgauugacuaagguuucc
agaggaaggcucguccgcucuggguuagucggguccuaagcugaggccga
caggcguaggcgauggauaacagguugauauuccuguaccaccuauaucg
auggggggacgcaguaggauaggcgaagcgugcgauuggauugcacgucu
aagcaguaaggauccgguacgcugagcugugauggggagaagacauugug
ucuucgagucguugauuucacacugccgagaaaagccucuagggugcccg
uaccgcaaaccgacacagguagucaagaugagaauucuaaggugagcgag
cgaacucucguuaaggaacucggcaaaaugaccccguaacuucgggagaa
ggggugcucuuuagggucccagaagagccgcagugaauaggcccaagcga
cuguuuaucaaaaacacaggucucugcuaaaccguaaggugauguauagg
ggcugacgccugcccagugcuggaagguuaagaggagugguuagcuucug
cgaagcuacgaaucgaagccccaguaaacggcggccguaacuauaacggu
ccuaagguagcgaaauuccuugucggguaaguuccgacccgcacgaaagg
cguaacgauuugggcacugucucaacgagagacucggugaaaucauagua
ccugugaagaugcagguuacccgcgacaggacggaaagaccccguggagc
uuuacuguagccugauauugaaaugcuuucuaacccgcaccacuuaucgu
ggugggagacagugucaggcgggcaguuugacuggggcggucgccuccua
aaagguaacggaggcgcucaaagguucccucagaaauucauagaguguaa
aggcauaagggagcuugacugcgagaccuacaagucgagcagggucgaaa
gacggacuuagugauccggugguuccgcauggaagggccaucgcucaacg
gauaaaagcuaccccggggauaacaggcuuaucucccccaagaguucaca
ucgacggggagguuuggcaccucgaugucggcucaucgcauccuggggcu
guagucggucccaaggguugggcuguucgcccauuaaagcgguacgcgag
cuggguucagaacgucgugagacaguucggucccuauccgucgugggcgu
aggaaauuugagaggagcuguccuuaguacgagaggaccgggauggacau
accucugguguaccaguugucgugccaacggcauagcuggguagcuaugu
guggacgggauaagugcugaaagcaucuaagcaugaagccccccucaaga
ugagauuucccaacuucgguuauaagaucccucaaagaugaugagguuaa
uagguucgagguggaagcauggugacauguggagcugacgaauacuaauc
gaucgaagacuuaau
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>.......>>>>.>.........<<....>>..<<<<<......<<....
.>>.....>>>>>..(((....<<<<<<........>>>>>>......<<
<<<<<<<...........<.<<<<<<<.<<<...<<<<<......>>>>>
((......<<<.....))>>>...>>>...>>>>>>>..>.....>>>>>
..>>>>.....<<<<<<<<.........>>>>>>>>......<<<<<..<
<<<>>>>>..)))......]].>>>>>>>.]]...............<<.
...>>....]].........<<<<....>>>>.............}....
>>>>>>>>>>>.......<<<<..<<<<......>>>>..>>>>...<.<
........>.>.<<<<<<....<<<<<<<.<<<<<..<<<...<<<....
.>>>...>>>...<<....>>..<<<<.....>>>>.....>>>>>.>>>
>>>>..<<.<..<<<<<<<.....<<<<<<<<<..<<<....<<<<<<..
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>>>>>>>>>...<<<.....>>>......>>>>>>...>..>.>>..<<<
<<<....<<<<<....>>>>><<<<<<<<<...<<<<<<<<<.....<<<
...<<<<<<<..>>>>>>>..>>.>.....>>>>.>>>>>..>>>>>>>.
>>..<<<<<<<<<<......>>>>>>>>>>....<<<......>>>...<
<<<.<<<...<<<(((.....<<<<<<...........<<..<<<<.<<<
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>>>>><<<<<<.....>>>>>>....>>>>>><.<<<<<<<.<<......
<<<<<.<<....>>.>>>>>...>>.>>>>>>>..>.....>>>>>><..
....<<....<<<<<<.......>>>>>><<<<....<<<<<.<<...<<
<<<<...<<.....>>.>>>>>>....((<<<<.<<...<<<...<<<..
..>>>...>>>...>>...<<<<<........>>>>>))<<<<.......
..<<<<....<<<<...<<...<....<.<<<.....{...>>>.>.<..
..<<<<...<<..........>>...>>>>.....>.....<<.......
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..>>.....<<......>>>>>>>.<<<.......>>>..>>>>..<<<<
....<<<<<<<<.<<.........<.....<<<<<....<....>.....
>>>>><<<<<<<.<<<.>>>.>>>>>>>............<<<<<<<<<.
.<<<.........>>>..<<<<<<<.....<<<....>>>.......>>>
>>>>.<<<<<.<<<..<<<<<<<..<<<<..<<...<<<<<<.<<....>
>..>>>>>>...>>..>>>>>>>>>..>>>>><<<<<<.......>>>>>
>........<...........<<<<<.......>>>>>.....>....>>
>>>..>>.>>>>>>>..>..>>.>>>>>>>>.>>>>>>.....>.....<
<<<<........>>>>>..<<<<<<<<.(((.[[......<<<<.[[<<<
<..<<<<<.<<<<<<<<<.<<<<...>>>>....<<.<<<<<<.....>>
>>>>>>.....>>>>>>>>>..>>>>>..<<<<.....>>>><<<<<<..
.........>>>>>>..<<...<<<<<<<...<<<.>>>.....<<.[.(
((>>....>>>>>>>...<<<<..<<<......>>>..>>>>.<<<....
>>>.>>)))]......<<<<<<<.((..>>>>..))>>>>>>>.......
......>>>>..]]>>>>.......<<<<.<.<<<<<<...<<.......
>>...>>>>>>...>>>>.>.......<.<<<.<<<<<<..<<<<<<<<<
......>>>>>>..>>>.<<<<<.....>>>>>.....>>>>>..>...>
>>..>....<<<<<<<....>>>.>>>>....]]..)))>>>>>>>>...
.<<<<<<<...<<<<..<<<<<<<...............>>>>>>>.<<<
<<...<<<<...<<<<<<<<<<<.}..>>>>>>..>>>>>...>>>>.>>
>>>...<<<.<..<<<<<...........>>>>>...>>>>.>>>>....
...>>>>>>>.<<<....>>>....<<<<<<<<<.......>>>>>....
<<<<<<<<.<<<....<<<<<....>>>>>...>>>..>>>>>.>>>...
>>>>....>>>>>..
Receptor-Ligand Complex Structure
Global viewLocal viewStructure summary

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PDB6wru Characterization of the Core Ribosomal Binding Region for the Oxazolidone Family of Antibiotics Using Cryo-EM.
Resolution3.1 Å
Binding residue
(original residue number in PDB)
E38 E39 T40 A41 R44 R47 K48 R52 R58
Binding residue
(residue number reindexed from 1)
E35 E36 T37 A38 R41 R44 K45 R49 R55
Enzymatic activity
Enzyme Commision number ?
Gene Ontology
Molecular Function
GO:0003735 structural constituent of ribosome
Biological Process
GO:0006412 translation
Cellular Component
GO:0005840 ribosome
GO:0022625 cytosolic large ribosomal subunit
GO:1990904 ribonucleoprotein complex

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Molecular Function

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Biological Process

View graph for
Cellular Component
External links
PDB RCSB:6wru, PDBe:6wru, PDBj:6wru
PDBsum6wru
PubMed32566908
UniProtQ2FW14|RL29_STAA8 Large ribosomal subunit protein uL29 (Gene Name=rpmC)

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