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SMILES

CACTVS 3.341

[Ca++]

ACDLabs 10.04
OpenEye OEToolkits 1.5.0

[Ca+2]

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Structure summary

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PDB	6ssa Identification of a superagonist variant of the immunodominant Yellow fever virus epitope NS4b214-222by combinatorial peptide library screening.
Resolution	2.11 Å
Binding residue (original residue number in PDB)	N83 H84 L87
Binding residue (residue number reindexed from 1)	N84 H85 L88
Annotation score	4

Molecular Function

GO:0005198

structural molecule activity

GO:0005515

protein binding

GO:0023026

MHC class II protein complex binding

GO:0042605

peptide antigen binding

GO:0042802

identical protein binding

GO:0042803

protein homodimerization activity

	Biological Process
GO:0001913	T cell mediated cytotoxicity
GO:0001916	positive regulation of T cell mediated cytotoxicity
GO:0002237	response to molecule of bacterial origin
GO:0002474	antigen processing and presentation of peptide antigen via MHC class I
GO:0002481	antigen processing and presentation of exogenous protein antigen via MHC class Ib, TAP-dependent
GO:0002502	peptide antigen assembly with MHC class I protein complex
GO:0002503	peptide antigen assembly with MHC class II protein complex
GO:0002726	positive regulation of T cell cytokine production
GO:0006826	iron ion transport
GO:0006879	intracellular iron ion homeostasis
GO:0006955	immune response
GO:0007608	sensory perception of smell
GO:0007611	learning or memory
GO:0010977	negative regulation of neuron projection development
GO:0019885	antigen processing and presentation of endogenous peptide antigen via MHC class I
GO:0019886	antigen processing and presentation of exogenous peptide antigen via MHC class II
GO:0032092	positive regulation of protein binding
GO:0033077	T cell differentiation in thymus
GO:0034756	regulation of iron ion transport
GO:0042026	protein refolding
GO:0045646	regulation of erythrocyte differentiation
GO:0048260	positive regulation of receptor-mediated endocytosis
GO:0050680	negative regulation of epithelial cell proliferation
GO:0050768	negative regulation of neurogenesis
GO:0050778	positive regulation of immune response
GO:0050870	positive regulation of T cell activation
GO:0051289	protein homotetramerization
GO:0060586	multicellular organismal-level iron ion homeostasis
GO:0071281	cellular response to iron ion
GO:0071283	cellular response to iron(III) ion
GO:0071316	cellular response to nicotine
GO:1900121	negative regulation of receptor binding
GO:1900122	positive regulation of receptor binding
GO:1904434	positive regulation of ferrous iron binding
GO:1904437	positive regulation of transferrin receptor binding
GO:1990000	amyloid fibril formation
GO:2000774	positive regulation of cellular senescence
GO:2000978	negative regulation of forebrain neuron differentiation

Biological Process

GO:0001913

T cell mediated cytotoxicity

GO:0001916

positive regulation of T cell mediated cytotoxicity

GO:0002237

response to molecule of bacterial origin

GO:0002474

antigen processing and presentation of peptide antigen via MHC class I

GO:0002481

antigen processing and presentation of exogenous protein antigen via MHC class Ib, TAP-dependent

GO:0002502

peptide antigen assembly with MHC class I protein complex

GO:0002503

peptide antigen assembly with MHC class II protein complex

GO:0002726

positive regulation of T cell cytokine production

GO:0006826

iron ion transport

GO:0006879

intracellular iron ion homeostasis

GO:0006955

immune response

GO:0007608

sensory perception of smell

GO:0007611

learning or memory

GO:0010977

negative regulation of neuron projection development

GO:0019885

antigen processing and presentation of endogenous peptide antigen via MHC class I

GO:0019886

antigen processing and presentation of exogenous peptide antigen via MHC class II

GO:0032092

positive regulation of protein binding

GO:0033077

T cell differentiation in thymus

GO:0034756

regulation of iron ion transport

GO:0042026

protein refolding

GO:0045646

regulation of erythrocyte differentiation

GO:0048260

positive regulation of receptor-mediated endocytosis

GO:0050680

negative regulation of epithelial cell proliferation

GO:0050768

negative regulation of neurogenesis

GO:0050778

positive regulation of immune response

GO:0050870

positive regulation of T cell activation

GO:0051289

protein homotetramerization

GO:0060586

multicellular organismal-level iron ion homeostasis

GO:0071281

cellular response to iron ion

GO:0071283

cellular response to iron(III) ion

GO:0071316

cellular response to nicotine

GO:1900121

negative regulation of receptor binding

GO:1900122

positive regulation of receptor binding

GO:1904434

positive regulation of ferrous iron binding

GO:1904437

positive regulation of transferrin receptor binding

GO:1990000

amyloid fibril formation

GO:2000774

positive regulation of cellular senescence

GO:2000978

negative regulation of forebrain neuron differentiation

	Cellular Component
GO:0000139	Golgi membrane
GO:0005576	extracellular region
GO:0005615	extracellular space
GO:0005765	lysosomal membrane
GO:0005783	endoplasmic reticulum
GO:0005788	endoplasmic reticulum lumen
GO:0005794	Golgi apparatus
GO:0005829	cytosol
GO:0005886	plasma membrane
GO:0005925	focal adhesion
GO:0009897	external side of plasma membrane
GO:0009986	cell surface
GO:0012507	ER to Golgi transport vesicle membrane
GO:0016020	membrane
GO:0030670	phagocytic vesicle membrane
GO:0031901	early endosome membrane
GO:0031902	late endosome membrane
GO:0031905	early endosome lumen
GO:0035580	specific granule lumen
GO:0042612	MHC class I protein complex
GO:0042613	MHC class II protein complex
GO:0042824	MHC class I peptide loading complex
GO:0055038	recycling endosome membrane
GO:0070062	extracellular exosome
GO:1904724	tertiary granule lumen
GO:1990712	HFE-transferrin receptor complex

Cellular Component

Golgi membrane

extracellular region

extracellular space

lysosomal membrane

endoplasmic reticulum

GO:0005788