Structure of PDB 6rny Chain K Binding Site BS01

Receptor Information

>6rny Chain K (length=338) Species: 11963 (Human spumaretrovirus) [Search protein sequence] [Download receptor structure] [Download structure with residue number starting from 1] [View receptor structure]

KVSRPEGVKIIPPQSDRQKIVLQAHNLAHTGREATLLKIANLYWWPNMRK
DVVKQLGRCQQCLITNASNKASGPILRPDRPQKPFDKFFIDYIGPLPPSQ
GYLYVLVVVDGMTGFTWLYPTKAPSTSATVKSLNVLTSIAIPKVIHSDQG
AAFTSSTFAEWAKERGIHLEFSTPYHPQSSGKVERKNSDIKRLLTKLLVG
RPTKWYDLLPVVQLALNNTYSPVLKYTPHQLLFGIDSNTPFANQDTLDLT
REEELSLLQEIRTSLYHPSTPPASSRSWSPVVGQLVQERVARPASLRPRW
HKPSTVLKVLNPRTVVILDHLGNNRTVSIDNLKPTSHQ

Ligand information

>6rny Chain I (length=128) [Search DNA sequence] [Download ligand structure] [Download structure with residue number starting from 1] [View ligand structure]

gcgaaattccatgacactaccttcccaggaaacaggtttcaccagccagg
ccttgaatgcaattgtcttactaggaatatttggacttccccacctacca
ttcaggtaacttgatacaaacacagccc

Receptor-Ligand Complex Structure

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Structure summary

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PDB	6rny Retroviral integration into nucleosomes through DNA looping and sliding along the histone octamer.
Resolution	3.9 Å
Binding residue (original residue number in PDB)	S105 N106 A108 P161 S162 T163 A188 S192 S193 S311 S312 R313 R326 R329 R336
Binding residue (residue number reindexed from 1)	S68 N69 A71 P124 S125 T126 A151 S155 S156 S274 S275 R276 R289 R292 R299

Enzymatic activity

Enzyme Commision number

2.7.7.-
2.7.7.49: RNA-directed DNA polymerase.
2.7.7.7: DNA-directed DNA polymerase.
3.1.-.-
3.1.26.4: ribonuclease H.
3.4.23.-

Gene Ontology

	Molecular Function
GO:0003676	nucleic acid binding

	Biological Process
GO:0015074	DNA integration

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Molecular Function

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Biological Process

External links

PDB	RCSB:6rny, PDBe:6rny, PDBj:6rny
PDBsum	6rny
PubMed	31519882
UniProt	P14350\|POL_FOAMV Pro-Pol polyprotein (Gene Name=pol)

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