Structure of PDB 6q6h Chain K Binding Site BS01

Receptor Information
>6q6h Chain K (length=518) Species: 9606 (Homo sapiens) [Search protein sequence] [Download receptor structure] [Download structure with residue number starting from 1] [View receptor structure]
NLERLRKRVRQYLDQQQYQSALFWADKVASLSREEPQDIYWLAQCLYLTA
QYHRAAHALRSRKLDKLYEACRYLAARCHYAAKEHQQALDVLDSIKSSIC
LLRGKIYDALDNRTLATYSYKEALKLDVYCFEAFDLLTSHHMLTAQEEKE
LLESLPLSKLCNEEQELLRFLFENKLKKYNKPSETVIPESVDGLQENLDV
VVSLAERHYYNCDFKMCYKLTSVVMEKDPFHASCLPVHIGTLVELNKANE
LFYLSHKLVDLYPSNPVSWFAVGCYYLMVGHKNEHARRYLSKATTLEKTY
GPAWIAYGHSFAVESEHDQAMAAYFTAAQLMKGCHLPMLYIGLEYGLTNN
SKLAERFFSQALSIAPEDPFVMHEVGVVAFQNGEWKTAEKWFLDALEKIK
AIGNEVTVDKWEPLLNNLGHVCRKLKKYAEALDYHRQALVLIPQNASTYS
AIGYIHSLMGNFENAVDYFHTALGLRRDDTFSVTMLGHCIEMYIGCYDFD
VHTMKTLKNIISPPWDFR
Ligand information
>6q6h Chain W (length=26) Species: 9606 (Homo sapiens) [Search peptide sequence] [Download ligand structure] [Download structure with residue number starting from 1] [View ligand structure]
MLRRKPTRLELKLDDIEEFENIRKDL
Receptor-Ligand Complex Structure
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PDB6q6h Cyclin A2 degradation during the spindle assembly checkpoint requires multiple binding modes to the APC/C.
Resolution3.2 Å
Binding residue
(original residue number in PDB)		Y242 Y243 C245 A339 H342 A345 V346 L369 Y373 D401 F403 H406 F413 K443 E445 P446 N449 N450 H453 R456 K457 Y487 L491 F514 M518 M525
Binding residue
(residue number reindexed from 1)		Y209 Y210 C212 A306 H309 A312 V313 L336 Y340 D368 F370 H373 F380 K410 E412 P413 N416 N417 H420 R423 K424 Y454 L458 F481 M485 M492
Enzymatic activity
Enzyme Commision number ?
Gene Ontology
Molecular Function
GO:0005515 protein binding
Biological Process
GO:0007346 regulation of mitotic cell cycle
GO:0016567 protein ubiquitination
GO:0031145 anaphase-promoting complex-dependent catabolic process
GO:0045842 positive regulation of mitotic metaphase/anaphase transition
GO:0051301 cell division
GO:0051445 regulation of meiotic cell cycle
GO:0070936 protein K48-linked ubiquitination
GO:0070979 protein K11-linked ubiquitination
GO:0141198 protein branched polyubiquitination
Cellular Component
GO:0005634 nucleus
GO:0005654 nucleoplasm
GO:0005680 anaphase-promoting complex
GO:0005737 cytoplasm
GO:0005813 centrosome
GO:0005819 spindle
GO:0005829 cytosol
GO:0005856 cytoskeleton
GO:0072686 mitotic spindle

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Molecular Function
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Biological Process
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Cellular Component
External links
PDB RCSB:6q6h, PDBe:6q6h, PDBj:6q6h
PDBsum6q6h
PubMed31455778
UniProtQ13042|CDC16_HUMAN Cell division cycle protein 16 homolog (Gene Name=CDC16)

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