Structure of PDB 6pev Chain K Binding Site BS01

Receptor Information
>6pev Chain K (length=478) Species: 5843 (Plasmodium falciparum NF54) [Search protein sequence] [Download receptor structure] [Download structure with residue number starting from 1] [View receptor structure]
MDKKAREYAQDALKFIQRSGSNFLACKNLKERLENNGFINLSEGETWNLN
KNEGYVLCKENRNICGFFVGKNFNIDTGSILISIGHIDSCALKISPNNNV
IKKKIHQINVECYGSGLWHTWFDRSLGLSGQVLYKKGNKLVEKLIQINKS
VLFLPSLAIHLQNRTRYDFSVKINYENHIKPIISTTLFNQLNKCKINTDN
SYPLLYLLSKELNCKEEDILDFELCLMDTQEPCFTGVYEEFIEGARFDNL
LGSFCVFEGFIELVNSIKNHTNDNIHNNLYISIGYDHEEIGSLSEVGARS
YCTKNFIDRIISSVFKKEIHEKNLSVQEIYGNLVNRSFILNVDMAHCSHP
NYPETVQDNHQLFFHEGIAIKYNTNKNYVTSPLHASLIKRTFELYYNKYK
QQIKYQNFMVKNDTPCGSTVGSMVAANLSMPGIDIGIPQLAMHSIREIAA
VHDVFFLIKGVFAFYTYYNQVLSTCVHD
Ligand information
Ligand IDZN
InChIInChI=1S/Zn/q+2
InChIKeyPTFCDOFLOPIGGS-UHFFFAOYSA-N
SMILES
SoftwareSMILES
CACTVS 3.341[Zn++]
ACDLabs 10.04
OpenEye OEToolkits 1.5.0		[Zn+2]
FormulaZn
NameZINC ION
ChEMBLCHEMBL1236970
DrugBankDB14532
ZINC
PDB chain6pev Chain K Residue 1000 [Download ligand structure] [Download structure with residue number starting from 1] [View ligand structure]
Receptor-Ligand Complex Structure
Global viewLocal viewStructure summary

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PDB6pev Bottom-up structural proteomics: cryoEM of protein complexes enriched from the cellular milieu.
Resolution3.2 Å
Binding residue
(original residue number in PDB)		H86 D324 D434
Binding residue
(residue number reindexed from 1)		H86 D248 D343
Annotation score4
Enzymatic activity
Enzyme Commision number 3.4.11.21: aspartyl aminopeptidase.
Gene Ontology
Molecular Function
GO:0004177 aminopeptidase activity
GO:0008237 metallopeptidase activity
GO:0008270 zinc ion binding
GO:0046872 metal ion binding
Biological Process
GO:0006508 proteolysis

View graph for
Molecular Function
View graph for
Biological Process
External links
PDB RCSB:6pev, PDBe:6pev, PDBj:6pev
PDBsum6pev
PubMed31768063
UniProtW7K6I8

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