Structure of PDB 6je4 Chain K Binding Site BS01

Receptor Information
>6je4 Chain K (length=1060) Species: 604162 (Neisseria meningitidis 8013) [Search protein sequence] [Download receptor structure] [Download structure with residue number starting from 1] [View receptor structure]
AAFKPNSINYILGLAIGIASVGWAMVEIDEEENPIRLIDLGVRVFERAEV
PKTGDSLAMARRLARSVRRLTRRRAHRLLRTRRLLKREGVLQAANFDENG
LIKSLPNTPWQLRAAALDRKLTPLEWSAVLLHLIKHRGYLSQRKNETADK
ELGALLKGVAGNAHALQTGDFRTPAELALNKFEKESGHIRNQRSDYSHTF
SRKDLQAELILLFEKQKEFGNPHVSGGLKEGIETLLMTQRPALSGDAVQK
MLGHCTFEPAEPKAAKNTYTAERFIWLTKLNNLRILEQGSERPLTDTERA
TLMDEPYRKSKLTYAQARKLLGLEDTAFFKGLRYGKDNAEASTLMEMKAY
HAISRALEKEGLKDKKSPLNLSPELQDEIGTAFSLFKTDEDITGRLKDRI
QPEILEALLKHISFDKFVQISLKALRRIVPLMEQGKRYDEACAEIYGDNT
EEKIYLPPIPADEIRNPVVLRALSQARKVINGVVRRYGSPARIHIETARE
VGKSFKDRKEIEKRQEENRKDREKAAAKFREYFPNFVGEPKSKDILKLRL
YEQQHGKCLYSGKEINLGRLNEKGYVEIDAALPFSRTWDDSFNNKVLVLG
SENQNKGNQTPYEYFNGKDNSREWQEFKARVETSRFPRSKKQRILLQKFD
EDGFKERNLNDTRYVNRFLCQFVADRMRLTGKGKKRVFASNGQITNLLRG
FWGLRKVRAENDRHHALDAVVVACSTVAMQQKITRFVRYKEMNAHQKTHF
PQPWEFFAQEVMIRVFGKPDGKPEFEEADTLEKLRTLLAEKLSSRPEAVH
EYVTPLFVSRAPNRKMSGQGHMETVKSAKRLDEGVSVLRVPLTQLKLKDL
EKMVNREREPKLYEALKARLEAHKDDPAKAFAEPFYKYDKAGNRTQQVKA
VRVEQVQKTGVWVRNHNGIADNATMVRVDVFEKGDKYYLVPIYSWQVAKG
ILPDRAVVQGKDEEDWQLIDDSFNFKFSLHPNDLVEVITKKARMFGYFAS
CHRGTGNINIRIHDLDHKIGKNGILEGIGVKTALSFQKYQIDELGKEIRP
CRLKKRPPVR
Ligand information
Receptor-Ligand Complex Structure
Global viewLocal viewStructure summary

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PDB6je4 Structures of Neisseria meningitidis Cas9 Complexes in Catalytically Poised and Anti-CRISPR-Inhibited States.
Resolution3.069 Å
Binding residue
(original residue number in PDB)		Y140 R144 G156 L158 L159 Y199 L246 M254 K266 N285 R287 K333 G334 K390 D418 K419 F420 R440 D442 R473 K656 F657 D658 Y672 R675 E845 T846 Q981 N1029 K1043 G1049 G1051 K1053 T1054
Binding residue
(residue number reindexed from 1)		Y139 R143 G153 L155 L156 Y196 L243 M251 K263 N282 R284 K330 G331 K387 D415 K416 F417 R437 D439 R465 K648 F649 D650 Y664 R667 E823 T824 Q959 N1007 K1021 G1027 G1029 K1031 T1032
Enzymatic activity
Enzyme Commision number 3.1.-.-
Gene Ontology
Molecular Function
GO:0003676 nucleic acid binding
GO:0003677 DNA binding
GO:0003723 RNA binding
GO:0004519 endonuclease activity
GO:0046872 metal ion binding
Biological Process
GO:0043571 maintenance of CRISPR repeat elements
GO:0051607 defense response to virus

View graph for
Molecular Function
View graph for
Biological Process
External links
PDB RCSB:6je4, PDBe:6je4, PDBj:6je4
PDBsum6je4
PubMed31668930
UniProtC9X1G5|CAS9_NEIM8 CRISPR-associated endonuclease Cas9 (Gene Name=cas9)

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