Structure of PDB 6hea Chain K Binding Site BS01

Receptor Information
>6hea Chain K (length=390) Species: 224325 (Archaeoglobus fulgidus DSM 4304) [Search protein sequence] [Download receptor structure] [Download structure with residue number starting from 1] [View receptor structure]
LLEKLKKLEEDYYKLRELYRRLEDEKKFIESERIRYEREVRRLRSEVERL
RSPPLLVGVVSDILEDGRVVVKSSTGPKFVVNTSQYINEEELKPGARVAL
NQQTLAIVNVLPTSKDPMVYGFEVEEKPEVSYEDIGGLDVQIEEIREAVE
LPLLKPELFAEVGIEPPKGVLLYGPPGTGKTLLAKAVANQTRATFIRVVG
SEFVQKYIGEGARLVREVFQLAKEKAPSIIFIDELDAIAARRTNSDTSGD
REVQRTMMQLLAELDGFDPRGDVKVIGATNRIDILDPAILRPGRFDRIIE
VPLPTFEGRIQIFKIHTRKMKLAEDVDFKELARITEGASGADIKAICTEA
GMFAIREERAKVTMLDFTKAIEKVLKKTTPIPDLKGVMFV
Ligand information
Ligand IDADP
InChIInChI=1S/C10H15N5O10P2/c11-8-5-9(13-2-12-8)15(3-14-5)10-7(17)6(16)4(24-10)1-23-27(21,22)25-26(18,19)20/h2-4,6-7,10,16-17H,1H2,(H,21,22)(H2,11,12,13)(H2,18,19,20)/t4-,6-,7-,10-/m1/s1
InChIKeyXTWYTFMLZFPYCI-KQYNXXCUSA-N
SMILES
SoftwareSMILES
OpenEye OEToolkits 1.5.0c1nc(c2c(n1)n(cn2)[C@H]3[C@@H]([C@@H]([C@H](O3)CO[P@](=O)(O)OP(=O)(O)O)O)O)N
CACTVS 3.341Nc1ncnc2n(cnc12)[CH]3O[CH](CO[P](O)(=O)O[P](O)(O)=O)[CH](O)[CH]3O
ACDLabs 10.04O=P(O)(O)OP(=O)(O)OCC3OC(n2cnc1c(ncnc12)N)C(O)C3O
CACTVS 3.341Nc1ncnc2n(cnc12)[C@@H]3O[C@H](CO[P@@](O)(=O)O[P](O)(O)=O)[C@@H](O)[C@H]3O
OpenEye OEToolkits 1.5.0c1nc(c2c(n1)n(cn2)C3C(C(C(O3)COP(=O)(O)OP(=O)(O)O)O)O)N
FormulaC10 H15 N5 O10 P2
NameADENOSINE-5'-DIPHOSPHATE
ChEMBLCHEMBL14830
DrugBankDB16833
ZINCZINC000012360703
PDB chain6hea Chain K Residue 401 [Download ligand structure] [Download structure with residue number starting from 1] [View ligand structure]
Receptor-Ligand Complex Structure
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PDB6hea Cryo-EM structures of the archaeal PAN-proteasome reveal an around-the-ring ATPase cycle.
Resolution7.04 Å
Binding residue
(original residue number in PDB)		I143 G185 T186 G187 K188 T189 L190 G348 A349
Binding residue
(residue number reindexed from 1)		I135 G177 T178 G179 K180 T181 L182 G340 A341
Annotation score5
Enzymatic activity
Enzyme Commision number ?
Gene Ontology
Molecular Function
GO:0005524 ATP binding
GO:0016887 ATP hydrolysis activity
GO:0036402 proteasome-activating activity
Biological Process
GO:0010498 proteasomal protein catabolic process
GO:0043161 proteasome-mediated ubiquitin-dependent protein catabolic process
GO:0043335 protein unfolding
GO:1901800 positive regulation of proteasomal protein catabolic process
Cellular Component
GO:0000502 proteasome complex
GO:0005737 cytoplasm
GO:0008540 proteasome regulatory particle, base subcomplex
GO:0022623 proteasome-activating nucleotidase complex

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Molecular Function
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Biological Process
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Cellular Component
External links
PDB RCSB:6hea, PDBe:6hea, PDBj:6hea
PDBsum6hea
PubMed30559193
UniProtO28303|PAN_ARCFU Proteasome-activating nucleotidase (Gene Name=pan)

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