Structure of PDB 6gwj Chain K Binding Site BS01

Receptor Information

>6gwj Chain K (length=334) Species: 9606 (Homo sapiens)

PAVLGFEGSANKIGVGVVRDGKVLANPRRTYVTPPGTGFLPGDTARHHRA
VILDLLQEALTESGLTSQDIDCIAYTKGPGMGAPLVSVAVVARTVAQLWN
KPLVGVNHCIGHIEMGRLITGATSPTVLYVSGGNTQVIAYSEHRYRIFGE
TIDIAVGNCLDRFARVLKISNDPSPGYNIEQMAKRGKKLVELPYTVKGMD
VSFSGILSFIEDVAHRMLATGECTPEDLCFSLQETVFAMLVEITERAMAH
CGSQEALIVGGVGCNVRLQEMMATMCQERGARLFATDERFCIDNGAMIAQ
AGWEMFRAGHRTPLSDSGVTQRYRTDEVEVTWRD

Ligand information

• Ligand ID: MG
• InChI: InChI=1S/Mg/q+2
• InChIKey: JLVVSXFLKOJNIY-UHFFFAOYSA-N
• SMILES:
  ACDLabs 10.04
  OpenEye OEToolkits 1.5.0: [Mg+2]
  CACTVS 3.341: [Mg++]
• Formula: Mg
• Name: MAGNESIUM ION
• DrugBank: DB01378
• PDB chain: 6gwj Chain K Residue 402

Receptor-Ligand Complex Structure

Structure summary

• PDB: 6gwj Defects in t 6 A tRNA modification due to GON7 and YRDC mutations lead to Galloway-Mowat syndrome.
• Resolution: 1.95 Å
• Binding residue (original residue number in PDB): H109 H113 D294
• Binding residue (residue number reindexed from 1): H108 H112 D293
• Annotation score: 1

Enzymatic activity

• Enzyme Commision number: 2.3.1.234: N(6)-L-threonylcarbamoyladenine synthase.

Gene Ontology

Molecular Function

• GO:0005515 protein binding
• GO:0016746 acyltransferase activity
• GO:0016747 acyltransferase activity, transferring groups other than amino-acyl groups
• GO:0046872 metal ion binding
• GO:0061711 N(6)-L-threonylcarbamoyladenine synthase activity

Biological Process

• GO:0002949 tRNA threonylcarbamoyladenosine modification
• GO:0006400 tRNA modification
• GO:0008033 tRNA processing
• GO:0070525 tRNA threonylcarbamoyladenosine metabolic process

Cellular Component

• GO:0000408 EKC/KEOPS complex
• GO:0005634 nucleus
• GO:0005654 nucleoplasm
• GO:0005737 cytoplasm
• GO:0005829 cytosol

External links

• PDB: RCSB:6gwj, PDBe:6gwj, PDBj:6gwj
• PDBsum: 6gwj
• PubMed: 31481669
• UniProt: Q9NPF4|OSGEP_HUMAN tRNA N6-adenosine threonylcarbamoyltransferase (Gene Name=OSGEP)