Structure of PDB 6gmn Chain K Binding Site BS01

Receptor Information
>6gmn Chain K (length=87) Species: 9606 (Homo sapiens) [Search protein sequence] [Download receptor structure] [Download structure with residue number starting from 1] [View receptor structure]
MMYVKLISSDGHEFIVKREHALTSGTIKAMLTNEVNFREIPSHVLSKVCM
YFTYKVRYTNSSTEIPEFPIAPEIALELLMAANFLDC
Ligand information
Ligand IDF4E
InChIInChI=1S/C8H7NO3/c1-11-8(10)6-4-7-5(9-6)2-3-12-7/h2-4,9H,1H3
InChIKeyLIIJOCBTGRORSY-UHFFFAOYSA-N
SMILES
SoftwareSMILES
OpenEye OEToolkits 2.0.6COC(=O)c1cc2c([nH]1)cco2
CACTVS 3.385COC(=O)c1[nH]c2ccoc2c1
FormulaC8 H7 N O3
Namemethyl 4~{H}-furo[3,2-b]pyrrole-5-carboxylate
ChEMBLCHEMBL4247887
DrugBank
ZINCZINC000003030560
PDB chain6gmn Chain K Residue 201 [Download ligand structure] [Download structure with residue number starting from 1] [View ligand structure]
Receptor-Ligand Complex Structure
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PDB6gmn Surface Probing by Fragment-Based Screening and Computational Methods Identifies Ligandable Pockets on the von Hippel-Lindau (VHL) E3 Ubiquitin Ligase.
Resolution1.94 Å
Binding residue
(original residue number in PDB)		E64 I65 E102 M105
Binding residue
(residue number reindexed from 1)		E39 I40 E77 M80
Annotation score1
Enzymatic activity
Enzyme Commision number ?
Gene Ontology
Biological Process
GO:0006511 ubiquitin-dependent protein catabolic process

View graph for
Biological Process
External links
PDB RCSB:6gmn, PDBe:6gmn, PDBj:6gmn
PDBsum6gmn
PubMed30040896
UniProtQ15369|ELOC_HUMAN Elongin-C (Gene Name=ELOC)

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