Structure of PDB 6ahr Chain K Binding Site BS01

Receptor Information
>6ahr Chain K (length=121) Species: 9606 (Homo sapiens) [Search protein sequence] [Download receptor structure] [Download structure with residue number starting from 1] [View receptor structure]
PVKDREAFQRLNFLYQAAHCVLAQDPENQALARFYCYTERTIAKRLVLRR
DPSVKRTLCRGCSSLLVPGLTCTQRQRRCRGQRWTVQTCLTCQRSQRFLN
DPGHLLWGDRPEAQLGSQADS
Ligand information
>6ahr Chain A (length=341) [Search RNA sequence] [Download ligand structure] [Download structure with residue number starting from 1] [View ligand structure]
auagggcggagggaagcucaucaguggggccacgagcugagugcguccug
ucacuccacucccaugucccuugggaaggucugagacuagggccagaggc
ggcccuaacagggcucucccugagcuucggggaggugaguucccagagaa
cggggcuccgcgcgaggucagacugggcaggagaugccguggaccccgcc
cuucggggaggggcccggcggaugccuccuuugccggagcuuggaacaga
cucacggccagcgaagugaguucaauggcugaggugagguaccccgcagg
ggaccucauaacccaauucagacuacucuccuccgcccauu
<<.<<<<<<<<<.<..((((.....<<<<..........<<<<.......
.>>>>............>>>>..[...<..<<<<<.....<<<.......
<<<<<.....>>>>><<<<<<<.....>>>>>>><<<<<<<.........
....<<<<<<.<<<<<<.......<<<<<.....<<<<<.<<.<<<<.<<
<....>>>.>>>>>>>>>>>..>>>>>>>>>.>>>>>>>>........>>
>>>>>.>>>....................))))<<<<<<<.<<<<...>>
>>>>>>>>>..]....>>>>>.>.....>>>>>>>>>>>>.
Receptor-Ligand Complex Structure
Global viewLocal viewStructure summary

[Spin on] [Spin off] [Reset]
[High quality] [Low quality]
[White background] [Black background]
[Spin on] [Spin off] [Reset]
[High quality] [Low quality]
[White background] [Black background]
PDB6ahr Cryo-EM Structure of the Human Ribonuclease P Holoenzyme.
Resolution3.92 Å
Binding residue
(original residue number in PDB)		Y40 V50 R52 R53 P55 K58 R59 R63 T76 R78 R80 R81 C82 R83 Q85 R86 W87 V89 T91 F101 L102 P105 W110 R113
Binding residue
(residue number reindexed from 1)		Y37 V47 R49 R50 P52 K55 R56 R60 T73 R75 R77 R78 C79 R80 Q82 R83 W84 V86 T88 F98 L99 P102 W107 R110
Enzymatic activity
Enzyme Commision number 3.1.26.5: ribonuclease P.
Gene Ontology
Molecular Function
GO:0003723 RNA binding
GO:0004526 ribonuclease P activity
GO:0005515 protein binding
GO:0033204 ribonuclease P RNA binding
GO:0046872 metal ion binding
Biological Process
GO:0001682 tRNA 5'-leader removal
GO:0006396 RNA processing
GO:0008033 tRNA processing
GO:0009410 response to xenobiotic stimulus
Cellular Component
GO:0005634 nucleus
GO:0005654 nucleoplasm
GO:0005655 nucleolar ribonuclease P complex
GO:0005730 nucleolus
GO:0030681 multimeric ribonuclease P complex
GO:1902555 endoribonuclease complex
GO:1990904 ribonucleoprotein complex

View graph for
Molecular Function
View graph for
Biological Process
View graph for
Cellular Component
External links
PDB RCSB:6ahr, PDBe:6ahr, PDBj:6ahr
PDBsum6ahr
PubMed30454648
UniProtQ9H633|RPP21_HUMAN Ribonuclease P protein subunit p21 (Gene Name=RPP21)

[Back to BioLiP]