Structure of PDB 5v93 Chain K Binding Site BS01

Receptor Information

>5v93 Chain K (length=121) Species: 1773 (Mycobacterium tuberculosis)

IQQESRLKVADNTGAKEILCIRVLGGSSRRYAGIGDVIVATVKDAIPGGN
VKRGDVVKAVVVRTVKERRRPDGSYIKFDENAAVIIKPDNDPRGTRIFGP
VGRELREKRFMKIISLAPEVL

Ligand information

>5v93 Chain A (length=3118)

aagugucuaagggcgcaugguggaugccuuggcaucgagagccgaugaag
gacgugggaggcugcgauaugccucggggagcugucaaccgagcguggau
ccgaggauuuccgaauggggaaacccagcacgagugaugucgugcuaccc
gcaucugaauauauagggugcgggagggaacgcggggaagugaaacaucu
caguacccguaggaggagaaaacaauugugauuccgcaaguaguggcgag
cgaacgcggaacaggcuaaaccgcacgcauggguaaccggguagggguug
ugugugcgggguugugggaggauaugucucagcgcuacccggcugagagg
cagucagaaagugucgugguuagcggaaguggccugggauggucugccgu
agacggugagagcccgguacgcgaaaacccggcaccugccuaguaucaau
ucccgaguagcagcgggcccguggaauccgcugugaauccgccgggacca
cccgguaagccuaaauacuccucgaugaccgauagcggauuaguaccgug
agggaauggugaaaaguaccccgggaggggagugaaagaguaccugaaac
cgugugccuacaauccgucagagccuccuuuuccucuccggaggagggug
gugauggcgugccuuuugaagaaugagccugcgagucagggacaugucgc
aagguuaacccgugugggguagccgcagcgaaagcgagucugaauagggc
gacccacacgcgcauacgcgcgugugaauaguggcguguucuggacccga
agcggagugaucuacccauggccagggugaagcgcggguaagaccgcgug
gaggcccgaacccacuuagguugaagacugaggggaugagcuguggguag
gggugaaaggccaaucaaacuccgugauagcugguucuccccgaaaugca
uuuaggugcagcguugcgugguucaccgcggagguagagcuacuggaugg
ccgauggguuacugacgucagccaaacuccgaaugccgugguguaaagcg
uggcagugagacggcgggggauaagcuccguacgucgaaagggaaacagc
ccagaucgccggcuaaggcccccaagcgugugcuaagugggaaaggaugu
gcagucgcaaagacaaccaggagguuggcuuagaagcagccacccuugaa
agagugcguaauagcucacuggucaagugauugugcgccgauaauguagc
ggggcucaagcacaccgccgaagccgcggcacauccaccuuguggugggu
guggguaggggagcgucccucauucagcgaagccaccgggugaccggugg
uggagggugggggagugagaaugcaggcaugaguagcgacaaggcaagug
agaaccuugcccgccgaaagaccaaggguuccugggccaggccaguccgc
ccagggugagucgggaccuaaggcgaggccgacaggcguagucgauggac
aacggguugauauucccguacccgugugugggcgcccgugacgaaucagc
gguacuaaccacccaaaaccggaucgaucacuccccuucgggggugugga
guucuggggcugcgugggaacuucgcugguaguagucaagcgaaggggug
acgcaggaagguagccguaccagucagugguaacacuggggcaagccggu
agggagagcgauaggcaaauccgucgcucacuaauccugagaggugacgc
auagccgguugaggcgaauucggugauccucugcugccaagaaaagccuc
uagcgagcacacacacggcccguaccccaaaccgacacagguggucaggu
agagcauaccaaggcguacgagauaacuaugguuaaggaacucggcaaaa
ugcccccguaacuucgggagaagggggaccggaauaucgugaacacccuu
gcggugggagcgggauccggucgcagaaaccagugaggagcgacuguuua
cuaaaaacacagguccgugcgaagucgcaagacgauguauacggacugac
gccugcccggugcuggaagguuaagaggacccguuaacccgcaaggguga
agcggagaauuuaagccccaguaaacggcggugguaacuauaaccauccu
aagguagcgaaauuccuugucggguaaguuccgaccugcacgaauggcgu
aacgacuucucaacugucucaaccauagacucggcgaaauugcacuacga
guaaagaugcucguuacgcgcggcaggacgaaaagaccccgggaccuuca
cuacaacuugguauugauguucgguacgguuuguguaggauaggugggag
acugugaaaccucgacgccaguuggggcggagucguuguugaaauaccac
ucugaucguauugggcaucuaaccucgaacccugaaucggguuuagggac
agugccuggcggguaguuuaacuggggcgguugccuccuaaaauguaacg
gaggcgcccaaagguucccucaaccuggacggcaaucagguggcgagugu
aaaugcacaagggagcuugacugcgagacuuacaagucaagcagggacga
aagucgggauuagugauccggcacccccgaguggaaggggugucgcucaa
cggauaaaagguaccccggggauaacaggcugaucuuccccaagagucca
uaucgacgggaugguuuggcaccucgaugucggcucgucgcauccugggg
cuggagcaggucccaaggguugggcuguucgcccauuaaagcggcacgcg
agcuggguuuagaacgucgugagacaguucggucucuauccgccgcgcgc
gucagaaacuugaggaaaccugucccuaguacgagaggaccgggacggac
gaaccucuggugcaccaguugucccgccaggggcaccgcuggauagccac
guucggucaggauaaccgcugaaagcaucuaagcgggaaaccuucuccaa
gaucagguuucucacccacuuggugggauaaggccccccgcagaacacgg
guucaauaggucagaccuggaagcucaguaauggguguagggaacuggug
cuaaccggccgaaaacuu

<<<<......<<<<<<<<<<<.....<<...<<<<<<<<<<<<......<
<<<<<.((.((..>>>.....<<<<<<<..<<<.))..)).>>>.....>
>>>>>>...>>>....<<<....>>><<<<<<<......>>>>>>>.<<<
<<<<<<.........>>>>>>>>>.>>...<<<<<<.....<<....>>.
.....>>>>>.>.........<<<..>>>..<<<<<<.....<<.....>
>....>>>>>>..<<<....<<<<<<<<<<......<<((((((>>...>
>>>>>>>>>......<<<<<<<<<..<<<<<<<.)))))).>>>>>>><<
<<........<<<<<..<<<<.<<<.....<<<<......>>>>.((...
...<<<.....))>>>...>>>...>>>>.>>>>>.>>>>...>>>>..>
>>>>.....<<<<<<<<.........>>>>>>>>......<<<<<..<<<
<>>>>>..>>>......>>.>>>>>>>.>................<<...
.>>....>>.........<<<<....>>>>..................>>
>>>>>>>>>.......<<<<..<<<.<<<<<.<.......>..>>>>>.>
>>..>>>>.....<........>...<<<<<<....<<<.<<<<<<<<<<
..<<<...<<<<..>>>>...>>>...<<....>>..<<<<.....>>>>
......<<<<<<<....>>>>>>>......>>>>>>>>>>>>>..<<...
.<.<<<<<.....<<<<<<<<<..<<<....<<<<<<......>>>>>>.
....>>>...<<<.<<<<<........>>>>>>>>....>>>>>>>>>..
.<<<.....>>>......>>>>>....>....>>..<<<<<<....<<<<
<....>>>>><<<<<<<<<....<<<<<<<.......<<....<<<.<<<
<...............>>>>.>>>..>>........>>>>>>>....>>>
>>>>.>>..<<<<<<<<<<......>>>>>>.>>>>....<<<......>
>>...<<<<.<<<...<<<(((.....<<<<<<...........<<..<<
<<<<<<<........<<<<<..<...<<...........>>...>.....
.....<<......>>...>>>>>....>>>>>>>>>.>>...........
)))......>>>>>>.>>>...>>>>>>><<<<<<<<<<....>>>>>>>
>>>....>>>>>><<<<<<<<<<<.......<<<<<<<<....>>>>>>>
>....>>>>>>>>>.>>.....>>>>>><......<<.....<<<<<...
......>>>>><<<<....<<<<<.<<...<<<<<<.............>
>>>>>....((.<<<.<.<..<<....<<<....>>>....>>...>>..
..<<<<........>>>>.))<<<<<<<<<.<<.....<<<<...<<<<<
<<.<....<<<<.<<...<<<<<.<..<<<<.<<<<<..>>>>>.>>>>.
>.>>>>>...>>.>>>>....>>>>>>>>.....>>>>.<<...<<<<<.
..<<.<..<<<..<<<<..<<<<<...((((...>>>>>.<...<<<...
.<<<<<<<<<<<.<<.....>>>>>>>>>.....>>>>....>>>....>
...<<........>>.....>>>>...>>>....>>>........>>>>.
>.>>..>>.>>>>>>>>>>>>...>>.....<<......>>>>>>>.<<<
<.....>>>>..>>>>..<<<<....<<<<<<<<................
..<<<<<.....<..>......>>>>><<<<<<...<<.<....<<<...
..>>>......>.>>>>>>>>............<<<<<<<<<..<<<...
......>>>..<<<<<<<.....<<<....>>>.......>>>>>>>.<<
<<<.<<<..<<<<<<<..<<<...<<....<<<<..<<<<....>>>>..
.>>>>....>>...>>>>>>>>..>>>>><<<<<.........>>>>>..
......<...........<<<<<.......>>>>>.....>....>>>>>
..>>.>>>>>>>........>>>>>>>>.>>>>>>.....>.....<<<<
<........>>>>>..<<<<<<<<.<<<.<<......<<<<<.<<<<..<
.<<....<.<<<<<.<<<<<<<<<<<<<.<....................
.........<<..............>>.......................
....>.>>>>>>>>>>>>>...<<<.<<<<<........>>>>>>>>...
.>>>>>.>.....>>..>..<..........><<<<<<...........>
>>>>>..<<...<<<<<<<...<<<<<<.......>>>>>>.....<<.[
.(((>>....>>>>>>>...<<<<..<<<<....>>>>..>>>>..<<..
..>>..>>)))]......<<<<<<<.<<..>>>>..>>>>>>>>>.....
........>>>>...>>>>>.......<<<<.<.<.<<<<...<<.....
..>>...>>>>.>...>>>>.>.......<.<<<...<<<<..<<<<<<<
<<......>>>>>>..>>>.<<<<<.....>>>>>.....>>>>......
.>>>..>....<<<<<<<....>>>.>>>>....>>..>>>>>>>>>>>.
...<<<<<<<...<<<...<<<<<<<...............>>>>>>>.<
<<<<...<<<<...<<<<<<<<<<<))))>>>>>>..>>>>>...>>>>.
>>>>>...<<<....<<<<<...........>>>>>....>>>..>>>..
.....>>>>>>>..<<<<<...>>>>>....<<<<..<<<.......>>>
.......<<<<<<..<<<....<<<<<....>>>>>...>>>...>>>>.
>>....>>>>....>>>>

Receptor-Ligand Complex Structure

Structure summary

• PDB: 5v93 Structural insights into species-specific features of the ribosome from the human pathogen Mycobacterium tuberculosis.
• Resolution: 4.0 Å
• Binding residue (original residue number in PDB): Q3 E5 S6 R7 I22 R23 S28 S29 R31 Y32 T42 K44 R54 G55 K67 E68 R70 Y76 R110
• Binding residue (residue number reindexed from 1): Q2 E4 S5 R6 I21 R22 S27 S28 R30 Y31 T41 K43 R53 G54 K66 E67 R69 Y75 R109

Gene Ontology

Molecular Function

• GO:0003735 structural constituent of ribosome
• GO:0019843 rRNA binding
• GO:0070180 large ribosomal subunit rRNA binding

Biological Process

• GO:0006412 translation

Cellular Component

• GO:0005840 ribosome
• GO:0005886 plasma membrane
• GO:0015934 large ribosomal subunit
• GO:0022625 cytosolic large ribosomal subunit
• GO:1990904 ribonucleoprotein complex

External links

• PDB: RCSB:5v93, PDBe:5v93, PDBj:5v93
• PDBsum: 5v93
• PubMed: 28977617
• UniProt: P9WHD9|RL14_MYCTU Large ribosomal subunit protein uL14 (Gene Name=rplN)