Structure of PDB 5tvp Chain K Binding Site BS01

Receptor Information
>5tvp Chain K (length=249) Species: 10090 (Mus musculus) [Search protein sequence] [Download receptor structure] [Download structure with residue number starting from 1] [View receptor structure]
SSTISFITWNIDGLDGCNLPERARGVCSCLALYSPDVVFLQEVIPPYCAY
LKKRAASYTIITGNEEGYFTAILLKKGRVKFKSQEIIPFPNTKMMRNLLC
VNVSLGGNEFCLMTSHLESTREHSAERIRQLKTVLGKMQEAPDSTTVIFA
GDTNLRDQEVIKCGGLPDNVFDAWEFLGKPKHCQYTWDTKANNNLRIPAA
YKHRFDRIFFRAEEGHLIPQSLDLVGLEKLDCGRFPSDHWGLLCTLNVV
Ligand information
Receptor-Ligand Complex Structure
Global viewLocal viewStructure summary

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PDB5tvp ZATT (ZNF451)-mediated resolution of topoisomerase 2 DNA-protein cross-links.
Resolution2.399 Å
Binding residue
(original residue number in PDB)		D132 E162 H236 S239 T240 D272 N274 R276 W307 L315 I317 Y321 H359
Binding residue
(residue number reindexed from 1)		D12 E42 H116 S119 T120 D152 N154 R156 W187 L195 I197 Y201 H239
Enzymatic activity
Enzyme Commision number 3.1.4.-
Gene Ontology
Molecular Function
GO:0003824 catalytic activity

View graph for
Molecular Function
External links
PDB RCSB:5tvp, PDBe:5tvp, PDBj:5tvp
PDBsum5tvp
PubMed28912134
UniProtQ9JJX7|TYDP2_MOUSE Tyrosyl-DNA phosphodiesterase 2 (Gene Name=Tdp2)

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