Structure of PDB 5f9h Chain K Binding Site BS01

Receptor Information
>5f9h Chain K (length=637) Species: 9606 (Homo sapiens) [Search protein sequence] [Download receptor structure] [Download structure with residue number starting from 1] [View receptor structure]
KPRNYQLELALPAMKGKNTIICAPTGCGKTFVSLLICEHHLKKFPQGQKG
KVVFFANQIPVYEQQKSVFSKYFERHGYRVTGISGATAENVPVEQIVENN
DIIILTPQILVNNLKKGTIPSLSIFTLMIFDECHNTSKQHPYNMIMFNYL
DQKLGGSSGPLPQVIGLTASVGVGDAKNTDEALDYICKLCASLDASVIAT
VKHNLEELEQVVYKPQKFFRKVESRIDKFKYIIAQLMRDTESLAKRIREF
GTQKYEQWIVTVQKACMVFQMPDKDEESRICKALFLYTSHLRKYNDALII
SEHARMKDALDYLKDFFSNVRAADEIEQDLTQRFEEKLQELESVSRDPSN
ENPKLEDLCFILQEEYHLNPETITILFVKTRALVDALKNWIEGNPKLSFL
KPGILTGDHNILIATSVADEGIDIAQCNLVILYEYVGNVIKMIQTRGRGR
ARGSKCFLLTSNAGVIEKEQINMYKEKMMNDSILRLQTWDEAVFREKILH
IQTHEKFIRDSQKPVPDKENKKLLCRKCKALACYTADVRVIEECHYTVLG
DAFKECFVSRPHPKPKQFSSFEKRAKIFCARQNCSHDWGIHVKYKTFEIP
VIKIESFVVEDIATGVQTLYSKWKDFHFEKIPFDPAE
Ligand information
>5f9h Chain L (length=23) [Search RNA sequence] [Download ligand structure] [Download structure with residue number starting from 1] [View ligand structure]
aauauaauagugauauuauauuc
<<<<<<<<<....>>>>>>>>>.
Receptor-Ligand Complex Structure
Global viewLocal viewStructure summary

[Spin on] [Spin off] [Reset]
[High quality] [Low quality]
[White background] [Black background]
[Spin on] [Spin off] [Reset]
[High quality] [Low quality]
[White background] [Black background]
PDB5f9h Structural basis for m7G recognition and 2'-O-methyl discrimination in capped RNAs by the innate immune receptor RIG-I.
Resolution3.1 Å
Binding residue
(original residue number in PDB)		I300 S325 G326 T347 Q349 K379 Q380 H381 Q507 E510 Q511 V514 R546 K635 T636 R637 G663 T697 V718 N720 S854 K888
Binding residue
(residue number reindexed from 1)		I59 S84 G85 T106 Q108 K138 Q139 H140 Q253 E256 Q257 V260 R292 K379 T380 R381 G407 T415 V436 N438 S569 K603
Binding affinityPDBbind-CN: Kd=1.8nM
Enzymatic activity
Enzyme Commision number 3.6.4.13: RNA helicase.
Gene Ontology
Molecular Function
GO:0003676 nucleic acid binding
GO:0005524 ATP binding

View graph for
Molecular Function
External links
PDB RCSB:5f9h, PDBe:5f9h, PDBj:5f9h
PDBsum5f9h
PubMed26733676
UniProtO95786|RIGI_HUMAN Antiviral innate immune response receptor RIG-I (Gene Name=RIGI)

[Back to BioLiP]