Structure of PDB 5f9f Chain K Binding Site BS01 |
| >5f9f Chain K (length=672) Species: 9606 (Homo sapiens)
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KPRNYQLELALPAMKGKNTIICAPTGCGKTFVSLLICEHHLKKFPQGQKG
KVVFFANQIPVYEQQKSVFSKYFERHGYRVTGISGATAENVPVEQIVENN
DIIILTPQILVNNLKKGTIPSLSIFTLMIFDECHNTSKQHPYNMIMFNYL
DQKLGGSSGPLPQVIGLTASVGVGDAKNTDEALDYICKLCASLDASVIAT
VKHNLEELEQVVYKPQKFFRKVESRISDKFKYIIAQLMRDTESLAKRICK
DLREFGTQKYEQWIVTVQKACMVFQMPDKDEESRICKALFLYTSHLRKYN
DALIISEHARMKDALDYLKDFFSNVRAAGFDEIEQDLTQRFEEKLQELES
VSRDPSNENPKLEDLCFILQEEYHLNPETITILFVKTRALVDALKNWIEG
NPKLSFLKPGILTGRGKTNQNTGMTLPAQKCILDAFKASGDHNILIATSV
ADEGIDIAQCNLVILYEYVGNVIKMIQTRGRGRARGSKCFLLTSNAGVIE
KEQINMYKEKMMNDSILRLQTWDEAVFREKILHIQTHEKFIRDSQEKPVP
DKENKKLLCRKCKALACYTADVRVIEECHYTVLGDAFKECFVSRPHPKPK
QFSSFEKRAKIFCARQNCSHDWGIHVKYKTFEIPVIKIESFVVEDIATGV
QTLYSKWKDFHFEKIPFDPAEM |
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| PDB | 5f9f Structural basis for m7G recognition and 2'-O-methyl discrimination in capped RNAs by the innate immune receptor RIG-I. |
| Resolution | 2.601 Å |
Binding residue
(original residue number in PDB) | N298 I300 S325 G326 T347 Q349 K379 Q380 H381 Q507 E510 Q511 K518 R546 K635 T636 R637 T662 G663 R664 T667 N668 T697 S698 N720 K750 H830 K851 F853 K858 I875 V886 K888 W908 |
Binding residue
(residue number reindexed from 1) | N57 I59 S84 G85 T106 Q108 K138 Q139 H140 Q258 E261 Q262 K269 R297 K386 T387 R388 T413 G414 R415 T418 N419 T448 S449 N471 K501 H579 K600 F602 K607 I624 V635 K637 W657 |
| Binding affinity | PDBbind-CN: Kd=38.5nM |
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| Enzyme Commision number |
3.6.4.13: RNA helicase. |
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