Structure of PDB 5f98 Chain K Binding Site BS01

Receptor Information
>5f98 Chain K (length=644) Species: 9606 (Homo sapiens) [Search protein sequence] [Download receptor structure] [Download structure with residue number starting from 1] [View receptor structure]
FKPRNYQLELALPAMKGKNTIICAPTGCGKTFVSLLICEHHLKKFPQGQK
GKVVFFANQIPVYEQQKSVFSKYFERHGYRVTGISGATAENVPVEQIVEN
NDIIILTPQILVNNLKKGTIPSLSIFTLMIFDECHNTSKQHPYNMIMFNY
LDQKLGGSSGPLPQVIGLTASVGVGDAKNTDEALDYICKLCASLDASVIA
TVKHNLEELEQVVYKPQKFFRKVESRISDKFKYIIAQLMRDTESLAKRIC
KDLNREFGTQKYEQWIVTVQKACMVFQMPDKDEESRICKALFLYTSHLRK
YNDALIISEHARMKDALDYLKDFFSNVREIEQDLTQRFEEKLQELESVSR
DPSNENPKLEDLCFILQEEYHLNPETITILFVKTRALVDALKNWIEGNPK
LSFLKPGILTGRDHNILIATSVADEGIDIAQCNLVILYEYVGNVIKMIQT
RGRGRARGSKCFLLTSNAGVIEKEQINMYKEKMMNDSILRLQTWDEAVFR
EKILHIQTHEKFIRDSQEKPPVPDKENKKLLCRKCKALACYTADVRVIEE
CHYTVLGDAFKECFVSRPHPKPKQFSSFEKRAKIFCARQNCSHDWGIHVK
YKTFEIPVIKIESFVVEDIATGVQTLYSKWKDFHFEKIPFDPAE
Ligand information
>5f98 Chain L (length=24) [Search RNA sequence] [Download ligand structure] [Download structure with residue number starting from 1] [View ligand structure]
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Receptor-Ligand Complex Structure
Global viewLocal viewStructure summary

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PDB5f98 Structural basis for m7G recognition and 2'-O-methyl discrimination in capped RNAs by the innate immune receptor RIG-I.
Resolution3.28 Å
Binding residue
(original residue number in PDB)		N298 Q299 I300 S325 G326 T347 Q349 K379 Q380 H381 Q507 E510 Q511 V514 R546 K635 T636 R637 G663 R664 T697 S698 N720 C829 H830 F853 I875 K888 S906
Binding residue
(residue number reindexed from 1)		N58 Q59 I60 S85 G86 T107 Q109 K139 Q140 H141 Q260 E263 Q264 V267 R299 K383 T384 R385 G411 R412 T420 S421 N443 C551 H552 F575 I597 K610 S628
Binding affinityPDBbind-CN: Kd=1.7nM
Enzymatic activity
Enzyme Commision number 3.6.4.13: RNA helicase.
Gene Ontology
Molecular Function
GO:0003676 nucleic acid binding
GO:0005524 ATP binding

View graph for
Molecular Function
External links
PDB RCSB:5f98, PDBe:5f98, PDBj:5f98
PDBsum5f98
PubMed26733676
UniProtO95786|RIGI_HUMAN Antiviral innate immune response receptor RIG-I (Gene Name=RIGI)

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