Structure of PDB 5cz2 Chain K Binding Site BS01

Receptor Information
>5cz2 Chain K (length=36) Species: 11758 (Mouse mammary tumor virus (STRAIN BR6)) [Search protein sequence] [Download receptor structure] [Download structure with residue number starting from 1] [View receptor structure]
LESAQESHALHHQNRFQFHITREQAREIVKLCPNCP
Ligand information
Ligand IDZN
InChIInChI=1S/Zn/q+2
InChIKeyPTFCDOFLOPIGGS-UHFFFAOYSA-N
SMILES
SoftwareSMILES
CACTVS 3.341[Zn++]
ACDLabs 10.04
OpenEye OEToolkits 1.5.0		[Zn+2]
FormulaZn
NameZINC ION
ChEMBLCHEMBL1236970
DrugBankDB14532
ZINC
PDB chain5cz2 Chain K Residue 301 [Download ligand structure] [Download structure with residue number starting from 1] [View ligand structure]
Receptor-Ligand Complex Structure
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PDB5cz2 Cryo-EM reveals a novel octameric integrase structure for betaretroviral intasome function.
Resolution2.72 Å
Binding residue
(original residue number in PDB)		H9 H13 C37 C40
Binding residue
(residue number reindexed from 1)		H8 H12 C32 C35
Annotation score1
Enzymatic activity
Enzyme Commision number 2.7.7.-
2.7.7.49: RNA-directed DNA polymerase.
2.7.7.7: DNA-directed DNA polymerase.
3.1.-.-
3.1.26.4: ribonuclease H.
3.4.23.-
3.6.1.23: dUTP diphosphatase.
Gene Ontology
Molecular Function
GO:0003676 nucleic acid binding
GO:0008270 zinc ion binding
Biological Process
GO:0015074 DNA integration

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Molecular Function
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Biological Process
External links
PDB RCSB:5cz2, PDBe:5cz2, PDBj:5cz2
PDBsum5cz2
PubMed26887496
UniProtP03365|POL_MMTVB Gag-Pro-Pol polyprotein (Gene Name=gag-pro-pol)

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