Structure of PDB 5anc Chain K Binding Site BS01

Receptor Information
>5anc Chain K (length=1120) Species: 9606 (Homo sapiens) [Search protein sequence] [Download receptor structure] [Download structure with residue number starting from 1] [View receptor structure]
MVLNSLDKMIQLQKNTANIRNICVLAHVDHGKTTLADCLISSNGIISSRL
AGKLRYMDSREDEQIRGITMKSSAISLHYATGNEEYLINLIDSPGHVDFS
SEVSTAVRICDGCIIVVDAVEGVCPQTQAVLRQAWLENIRPVLVINKIDR
LIVELKFTPQEAYSHLKNILEQINALTGTLFTSKVLEERAERETESQVNP
NSEQGEQVYDWSTGLEDTDDSHLYFSPEQGNVVFTSAIDGWGFGIEHFAR
IYSQKIGIKKEVLMKTLWGDYYINMKAKKIMKGDQAKGKKPLFVQLILEN
IWSLYDAVLKKDKDKIDKIVTSLGLKIGAREARHSDPKVQINAICSQWLP
ISHAVLAMVCQKLPSPLDITAERVERLMCTGSQTFDSFPPETQALKAAFM
KCGSEDTAPVIIFVSKMFAVDAKALPQNKPRPLTQEEIAQRRERARQRHA
EKLAAAQGQAPLEPTQDGSAIETCPKGEEPRGDEQQVESMTPKPVLQEEN
NQESFIAFARVFSGVARRGKKIFVLGPKYSPLEFLRRVPLGFSAPPDGLP
QVPHMAYCALENLYLLMGRELEYLEEVPPGNVLGIGGLQDFVLKSATLCS
LPSCPPFIPLNFEATPIVRVAVEPKHPSEMPQLVKGMKLLNQADPCVQIL
IQETGEHVLVTAGEVHLQRCLDDLKERFAKIHISVSEPIIPFRETITKPP
KVDMVNEEIGKQQKVAVIHQMKEDQSKIPEGIQVDSDGLITITTPNKLAT
LSVRAMPLPEEVTQILEENSDLIRSMEQLTSSLNEGENTHMIHQKTQEKI
WEFKGKLEQHLTGRRWRNIVDQIWSFGPRKCGPNILVNKSEDFQNSVWTG
PADKASKEASRYRDLGNSIVSGFQLATLSGPMCEEPLMGVCFVLEKWDLS
KFEEQGASDLAKEGQEENETCSGGNENQELQDGCSEAFEKRTSQKGESPL
TDCYGPFSGQLIATMKEACRYALQVKPQRLMAAMYTCDIMATGDVLGRVY
AVLSKREGRVLQEEMKEGTDMFIIKAVLPVAESFGFADEIRKRTSGLASP
QLVFSHWEIIPSDPFWVPTTEEEYLHFGEKADSENQARKYMNAVRKRKGL
YVEEKIVEHAEKQRTLSKNK
Ligand information
>5anc Chain N (length=1162) [Search RNA sequence] [Download ligand structure] [Download structure with residue number starting from 1] [View ligand structure]
auuagcaguuucgggggcguaaugcucucagcugauucucaaacucugaa
cauuuuugguaagcagaacuggcgauguggguugaaccaaauauugggau
aagacgucuaacauucacuaauagauaccacaaaagguguuaguucauua
agacagcaggacgguggccauggaagucgguauccgcuaaggagugugua
acaacucaccugccaaauggacuagcccugaaaauggaugacgcuagcag
uggauggucgaugcccaaucguuaaaagaagugauaauacuuuuaacaau
ccaacuguuuaauuaaaacaaagcauugcgauaagcuuaaaagcuuuuga
cgcaaugugauuucugcccagugcucugaaugucaaagugaagagauuca
accuagcacggguaaacggcgggaguaacuaugacucucuuaagguagcc
aaaugccucgucaucuaauuagugacgcgcaugaauggaucaaugagauu
cccacugucccuaacuacuauacagcgaaaccacugcaaggggaacgggc
cuugcaaaaacagcggggaaagaagacccuguugagcuugacucuagucu
gauauuaacaguuucagguggggaguuuggcuggggcggcacauuuguua
aaagauaacgcaaguguccaaaggcaggcucagugagaacagaaaucuca
cguagaguaaaagggcaaaagccugcuugauucugauuuucaguacuaau
cggaacugggaaaccagggccuaucgauccuuuaugugcuuaaaucuuaa
cccuagaggugucagaaaaguuaccacagggauaacuggcuuguggcagc
caagcgcucauagcgacgcugcuuuuugauccuucgaugucggcucuucu
uaucauugugaagcagaauucacaaaguguuggauuguucacccacuaac
aaggaacgugagcuggguuuagaccgucgugagacagguuaguuuuaccc
uacuguugucaauuguuugcguaauaguagcaugauuuaguacgagagga
acugucaugccggaucacuggucuguagguuuauuugacaaaauagugac
cugccgcuaccauccguuggauaauggcugaacgccucuaagucagaauc
cauucuagaaac
...<.<<<<<..<<<<<<.....>>>>>>>>>>>.>..............
<<.<<<<<.....>>>>>.>>......<<<......>>>...<<<<<<..
..<<<(((...<<<<<<<....<<..........<<<.<<<<<<<<<<..
.....<<<<<.<<<..<<<.........>>>..>>>.........<<...
...>>...>>>>>...>>>>>>>>>>>>>..........))).>>....>
>>>>>>>>>....>>>>>>.<<<<<<<<...........>>>>>>>><<<
<<<..<<<.........>>>..<<<<<<<....<<<<....>>>>.....
.>>>>>>>...<<..<<<..<<<<<<.....<<....<<<<<....>>>>
.>...>>..>>>>..>>>>><<<<<<.......>>>>>>........<..
.........<<<<<.......>>>>>.....>.....>>....>>.>>>>
....................................<<<<<........>
>>>>....<<<<<..<<<.<<......<<<<.<<<<<<..<<<<<.<<<<
<<.<<.....>>.>>>>>>..>>>>>...<<<.....>>>..<<<<<<..
.........>>>>>>..<<...<<<<<<<...<<<<<<.......>>>>>
>.....<<[..(((>>....>>>>>>>...<<<<<<<<.........>>>
>>>>>.<<<....>>>.>>))).]....<<<<<<...<.<<.......>>
.>.>>>>>>.........>>>>..>>>>>>.......<<.<.<.<<<<<<
...<<.......>>...>>>>>>...>>.>.>.......<<<<<..<<<<
<..<<<<<<<<<......>>>>>>>..>>.<<<.<.....>.>>>.....
>>>>>......>>>.>>....<<<<<<<....>>>.>>>>....>>..>>
>.>>>>>.............<<..<<<..<<<<<<<..............
...>>>>>>><<<<<...<<<<....<<<<<<<<<......>>>>..>>>
>>...>>>>..>>>>>.<<<<...<<<<<...........>>>>>...>>
>>..>>>...>>
Receptor-Ligand Complex Structure
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PDB5anc Mechanism of Eif6 Release from the Nascent 60S Ribosomal Subunit
Resolution4.2 Å
Binding residue
(original residue number in PDB)
D62 I65 R66 G67 I68 T69 G993 L996 G997 Y1000 K1005 R1009 V1010 E1013 Q1113 R1114
Binding residue
(residue number reindexed from 1)
D62 I65 R66 G67 I68 T69 G993 L996 G997 Y1000 K1005 R1009 V1010 E1013 Q1113 R1114
Enzymatic activity
Catalytic site (original residue number in PDB) K32 T33 T69 H96
Catalytic site (residue number reindexed from 1) K32 T33 T69 H96
Enzyme Commision number ?
Gene Ontology
Molecular Function
GO:0003746 translation elongation factor activity
GO:0003924 GTPase activity
GO:0005525 GTP binding
GO:0043022 ribosome binding
Biological Process
GO:0006412 translation
GO:0006414 translational elongation
GO:0042254 ribosome biogenesis
GO:0042256 cytosolic ribosome assembly
GO:0046039 GTP metabolic process
Cellular Component
GO:0005829 cytosol
GO:1990904 ribonucleoprotein complex

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Molecular Function

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Biological Process

View graph for
Cellular Component
External links
PDB RCSB:5anc, PDBe:5anc, PDBj:5anc
PDBsum5anc
PubMed26479198
UniProtQ7Z2Z2|EFL1_HUMAN Elongation factor-like GTPase 1 (Gene Name=EFL1)

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