Structure of PDB 4hx3 Chain K Binding Site BS01

Receptor Information
>4hx3 Chain K (length=133) Species: 53502 (Streptomyces caespitosus) [Search protein sequence] [Download receptor structure] [Download structure with residue number starting from 1] [View receptor structure]
PMVTVTYDPSNAPSFQQEIANAAQIWNSSVRNVQLRAGGNADFSYYEGND
SRGSYAQTDGHGRGYIFLDYQQNQQYDSTRVTAHETGHVLGLPDHYQGPC
SELMSGGGPGPSCTNPYPNAQERSRVNALWANG
Ligand information
Ligand IDZN
InChIInChI=1S/Zn/q+2
InChIKeyPTFCDOFLOPIGGS-UHFFFAOYSA-N
SMILES
SoftwareSMILES
CACTVS 3.341[Zn++]
ACDLabs 10.04
OpenEye OEToolkits 1.5.0		[Zn+2]
FormulaZn
NameZINC ION
ChEMBLCHEMBL1236970
DrugBankDB14532
ZINC
PDB chain4hx3 Chain K Residue 201 [Download ligand structure] [Download structure with residue number starting from 1] [View ligand structure]
Receptor-Ligand Complex Structure
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PDB4hx3 Mechanism of action of a Janus-faced single-domain protein inhibitor simultaneously targeting two peptidase classes
Resolution2.7 Å
Binding residue
(original residue number in PDB)		H83 H87 D93
Binding residue
(residue number reindexed from 1)		H84 H88 D94
Annotation score4
Enzymatic activity
Enzyme Commision number 3.4.24.77: snapalysin.
Gene Ontology
Molecular Function
GO:0004222 metalloendopeptidase activity
GO:0008237 metallopeptidase activity
GO:0008270 zinc ion binding
GO:0046872 metal ion binding
Biological Process
GO:0006508 proteolysis
Cellular Component
GO:0005576 extracellular region

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Molecular Function
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Biological Process
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Cellular Component
External links
PDB RCSB:4hx3, PDBe:4hx3, PDBj:4hx3
PDBsum4hx3
PubMed
UniProtP56406|SNPA_STRCS Extracellular small neutral protease (Gene Name=snpA)

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