Structure of PDB 4gam Chain K Binding Site BS01

Receptor Information
>4gam Chain K (length=511) Species: 243233 (Methylococcus capsulatus str. Bath) [Search protein sequence] [Download receptor structure] [Download structure with residue number starting from 1] [View receptor structure]
AANRAPTSVNAQEVHRWLQSFNWDFKNNRTKYATKYKMANETKEQFKLIA
KEYARMEAVKDERQFGSLQDALTRLNAGVRVHPKWNETMKVVSNFLEVGE
YNAIAATGMLWDSAQAAEQKNGYLAQVLDEIRHTHQCAYVNYYFAKNGQD
PAGHNDARRTRTIGPLWKGMKRVFSDGFISGDAVECSLNLQLVGEACFTN
PLIVAVTEWAAANGDEITPTVFLSIETDELRHMANGYQTVVSIANDPASA
KYLNTDLNNAFWTQQKYFTPVLGMLFEYGSKFKVEPWVKTWNRWVYEDWG
GIWIGRLGYGVESPRSLKDAKQDAYWAHHDLYLLAYALWPTGFFRLALPD
QEEMEWFEANYPGWYDHYGKIYEEWRARGCEDPSSGFIPLMWFIENNHPI
YIDRVSQVPFCPSLAKGASTLRVHEYNGQMHTFSDQWGERMWLAEPERYE
CQNIFEQYEGRELSEVIAELHGLRSDGKTLIAQPHVRGDKLWTLDDIKRL
NCVFKNPVKAF
Ligand information
Ligand IDFE
InChIInChI=1S/Fe/q+3
InChIKeyVTLYFUHAOXGGBS-UHFFFAOYSA-N
SMILES
SoftwareSMILES
ACDLabs 10.04
CACTVS 3.341
OpenEye OEToolkits 1.5.0		[Fe+3]
FormulaFe
NameFE (III) ION
ChEMBL
DrugBankDB13949
ZINC
PDB chain4gam Chain K Residue 601 [Download ligand structure] [Download structure with residue number starting from 1] [View ligand structure]
Receptor-Ligand Complex Structure
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PDB4gam Control of substrate access to the active site in methane monooxygenase.
Resolution2.902 Å
Binding residue
(original residue number in PDB)		E114 E144 H147 E243
Binding residue
(residue number reindexed from 1)		E100 E130 H133 E229
Annotation score1
Enzymatic activity
Catalytic site (original residue number in PDB) E114 E144 H147 E209 E243 H246
Catalytic site (residue number reindexed from 1) E100 E130 H133 E195 E229 H232
Enzyme Commision number 1.14.13.25: methane monooxygenase (soluble).
Gene Ontology
Molecular Function
GO:0004497 monooxygenase activity
GO:0005515 protein binding
GO:0015049 methane monooxygenase [NAD(P)H] activity
GO:0016491 oxidoreductase activity
GO:0046872 metal ion binding
Biological Process
GO:0006730 one-carbon metabolic process

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Molecular Function
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Biological Process
External links
PDB RCSB:4gam, PDBe:4gam, PDBj:4gam
PDBsum4gam
PubMed23395959
UniProtP22869|MEMA_METCA Methane monooxygenase component A alpha chain (Gene Name=mmoX)

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