Structure of PDB 1ucy Chain K Binding Site BS01

Receptor Information
>1ucy Chain K (length=259) Species: 9913 (Bos taurus) [Search protein sequence] [Download receptor structure] [Download structure with residue number starting from 1] [View receptor structure]
IVEGQDAEVGLSPWQVMLFRKSPQELLCGASLISDRWVLTAAHCLLYPPW
DKNFTVDDLLVRIGKHSRTRYERKVEKISMLDKIYIHPRYNWKENLDRDI
ALLKLKRPIELSDYIHPVCLPDKQTAAKLLHAGFKGRVTGWGNRRETWTT
SVAEVQPSVLQVVNLPLVERPVCKASTRIRITDNMFCAGYKPGEGKRGDA
CEGDSGGPFVMKSPYNNRWYQMGIVSWGEGCDRDGKYGFYTHVFRLKKWI
QKVIDRLGS
Ligand information
>1ucy Chain G (length=11) Species: 9543 (Macaca fuscata fuscata) [Search peptide sequence] [Download ligand structure] [Download structure with residue number starting from 1] [View ligand structure]
DFLAEGGGVRP
Receptor-Ligand Complex Structure
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PDB1ucy Bovine thrombin complexed with an uncleavable analog of residues 7-19 of fibrinogen A alpha: geometry of the catalytic triad and interactions of the P1', P2', and P3' substrate residues.
Resolution2.2 Å
Binding residue
(original residue number in PDB)		L41 H57 Y60A W60D K97 E97A L99 R173 I174 D189 A190 G193 S195 W215 G216
Binding residue
(residue number reindexed from 1)		L27 H43 Y47 W50 K93 E94 L96 R178 I179 D199 A200 G203 S205 W227 G228
Enzymatic activity
Enzyme Commision number 3.4.21.5: thrombin.
Gene Ontology
Molecular Function
GO:0004252 serine-type endopeptidase activity
GO:0005509 calcium ion binding
Biological Process
GO:0006508 proteolysis
GO:0007596 blood coagulation

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Molecular Function
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Biological Process
External links
PDB RCSB:1ucy, PDBe:1ucy, PDBj:1ucy
PDBsum1ucy
PubMed8855938
UniProtP00735|THRB_BOVIN Prothrombin (Gene Name=F2)

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