Structure of PDB 1hvu Chain K Binding Site BS01
Receptor Information
>1hvu Chain K (length=400) Species:
11676
(Human immunodeficiency virus 1) [
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IETVPVKLKPGMDGPKVKQWPLTEEKIKALVEICTEMEKEGKISKIGPEN
PYNTPVFAIKKKDSTKWRKLVDFRELNKRTQDFWEVQLGIPHPAGLKKKK
SVTVLDVGDAYFSVPLDEDFRKYTAFTIPSINNETPGIRYQYNVLPQGWK
GSPAIFQSSMTKILEPFKKQNPDIVIYQYMDDLYVGSDLEIGQHRTKIEE
LRQHLLRHPDKWTVQPIVLPEKDSWTVNDIQKLVGKLNWASQIYPGIKVR
QLCKLLRGTKALTEVIPLTEEAELELAENREILKEPVHGVYYDPSKDLIA
EIQKQGQGQWTYQIYQEPFKNLKTGKYARMRGAHTNDVKQLTEAVQKITT
ESIVIWGKTPKFKLPIQKETWETWWTEYWQATWIPEWEFVNTPPLVKLWY
Ligand information
>1hvu Chain L (length=30) [
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agauuccguuuucagucgggaaaaacugaa
....((((..<<<<<.)))).....>>>>>
Receptor-Ligand Complex Structure
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PDB
1hvu
The structure of HIV-1 reverse transcriptase complexed with an RNA pseudoknot inhibitor.
Resolution
4.75 Å
Binding residue
(original residue number in PDB)
K20 V21 K22 F416 V417
Binding residue
(residue number reindexed from 1)
K16 V17 K18 F389 V390
Enzymatic activity
Enzyme Commision number
2.7.7.-
2.7.7.49
: RNA-directed DNA polymerase.
2.7.7.7
: DNA-directed DNA polymerase.
3.1.-.-
3.1.13.2
: exoribonuclease H.
3.1.26.13
: retroviral ribonuclease H.
3.4.23.16
: HIV-1 retropepsin.
Gene Ontology
Molecular Function
GO:0003964
RNA-directed DNA polymerase activity
Biological Process
GO:0006278
RNA-templated DNA biosynthetic process
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Molecular Function
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Biological Process
External links
PDB
RCSB:1hvu
,
PDBe:1hvu
,
PDBj:1hvu
PDBsum
1hvu
PubMed
9687519
UniProt
P03366
|POL_HV1B1 Gag-Pol polyprotein (Gene Name=gag-pol)
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