Structure of PDB 7a5i Chain J3 Binding Site BS01

Receptor Information
>7a5i Chain J3 (length=140) Species: 9606 (Homo sapiens) [Search protein sequence] [Download receptor structure] [Download structure with residue number starting from 1] [View receptor structure]
GVIRAIVRAGLAMPGPPLGPVLGQRGVSINQFCKEFNERTKDIKEGIPLP
TKILVKPDRTFEIKIGQPTVSYFLKAAAGIEKGARQTGKEVAGLVTLKHV
YEIARIKAQDEAFALQDVPLSSVVRSIIGSARSLGIRVVK
Ligand information
>7a5i Chain A3 (length=1485) [Search RNA sequence] [Download ligand structure] [Download structure with residue number starting from 1] [View ligand structure]
gcuaaaccuagccccaaacccacuccaccuuacuaccagcaaccuuagcc
aaaccauuuacauaaaguauaggcgauagaaauuguggcgcaauagauau
aguaccgcaagggaaagaugaaaaauuauaaccaagcauaauauagcaag
gacuaaccccuauaccuucugcauaaugaauuaacuagaaauaacuuugc
aaggagagccaaagcuaagacccccgaaaccagacgagcuaccuaagaac
agcuaagagcacacccgucuauguagcaaaauagugggaagauuuauagg
uagaggcgacaaaccuaccgagccuggugauagcugguuguccaagauag
aaucuuaguucaacuuuaaauuugcccacagaaccaaauccccuuguaaa
uuuaacuguuaguccaaagaggaacagcucuuuggacacuaggaaaaaac
cuuguagagagaguaaaaaauuuaacacccauaguaggccuaaaagcagc
caccaauuaagaaagcguucaagcucaacacccacuaccuaaaaaauccc
aaacauauaacugaacuccucacacccaauuggaccaaucuaucacccua
uagaagaacuaauguuaguauaaguaacaugaaaacauucuccuccgcau
aagccugcgucagaucacacugacaauuaacagcccaauaucuacaauca
accaacaagucauuauuacccucacugucaacccaacacaggcaugcuca
uaaggaaagguuaaaaaaaguaaaaggaacucggcaaaucuuaccccgcc
uguuuaccaaaaacaucaccucuagcaucaccaguauuagaggcaccgcc
ugcccagugacacauguuuaacggccgcgguacccuaaccgugcaaaggu
agcauaaucacuuguuccuuaaauagggaccuguaugaauggcuccacga
ggguucagcugucucuuacuuuuaaccagugaaauugaccugcccgugaa
gaggcgggcauaacacagcaagacgagaagacccuauggagcuuuaauuu
auuaaugcaaacaguaaccugcauuaaaaauuucgguuggggcgaccucg
gagcagaacccaaccuccgagcaguacaugcuaagacuucaccagucaaa
gcgaaccucaauugauccaauaacuugaccaacggaacaaguuacccuag
ggauaacagcgcaauccuauucuagaguccauaucaacaauaggguuuac
gaccucgauguuggaucaggacaucccgauggugcagccgcuauuaaagg
uucguuuguucaacgauuaaaguccuacgugaucugaguucagaccggag
uaauccaggucgguuucuaucuacuuuauuccucccuguacgaaaggaca
agagaaauaaggccuacuucacaaagcgccuucccccguaaaugauauca
ucucaacuuagauacccacacccaagaacaggguu
<<<.......<<<<....................................
<......>.....<.....<<.....>>....>...>>.>>.........
....<<....>>......................>>>...........<<
<.......>>>...<.<........>.>.<<<<<<.........<<<.<<
..<<....>>...>>.>>>...<<.<..<<<<<.<.....<<<<<.<<<.
.<<<...>>>...<<<..<<<<........>>>>.>>>....>>>.>>>>
>...<<.......>>......>.>>>>...>..>.>>..<<<<<<....<
<<<....>>>><<<.<<<<<<<<<<.....<<......>>.....>>>>>
>>>>>..>>>.<<<<<<<<<<......>>>>>>>>>>...<<<......>
>>....<<<.<<<...<..............<....<<<.........>>
>....>.......<<<......>>>.........................
...........>...>>>>>>........>>>>>>...<<<<<......>
>>>>.........>>>>>>.......<<..<<<....>>><<<<..<<<<
........<<<<<......>>>>>......<<<...<<<<..........
.............>>>>.......>>>.....<<......>>.>>>>...
..>>>>..<<<<...<<<<<<<<.<<................<<<<<<..
<<<.........>>>...<<<<<<.............>>>>>>....<<<
.<<<..<<<<<....>>>..>>>>><<<<<<......>>>>>>.......
.<...........<<<<<<.....>>>>>>.....>....>>>....>>.
>>>>........>>.>>>>>>>>>>>>.>>...........<<<<<....
....>>>>>.......<<..<<<.<<......<<<<.<<<<<<..<<<<<
.<<<<<<<<..........>>>>>>>>>>>>>..<<<<.....>>>><<<
<<<...........>>>>>>..<<.....<<<..<<<<.....>>>>..>
>>....>>.........<<<....>>>............>>>>..>>>>>
>.......<<<..<.<<<<<<...<<.......>>...>>>>>>...>.>
>.>.......<<<<<.<<<<<<..<<.<<<<<<......>>>>>>...>>
.<<<<<.....>>>>>.....>>>>>..>...>>>.>>....<<<<<<<.
...>>>.>>>>....>>..>>>.>>..<<<.<<<................
.>>>.>>><<<<<...<<<....>>>.>>>>>......<<<.........
.......>>>.........<<<<.......>>>>.
Receptor-Ligand Complex Structure
Global viewLocal viewStructure summary

[Spin on] [Spin off] [Reset]
[High quality] [Low quality]
[White background] [Black background]
[Spin on] [Spin off] [Reset]
[High quality] [Low quality]
[White background] [Black background]
PDB7a5i Elongational stalling activates mitoribosome-associated quality control.
Resolution3.7 Å
Binding residue
(original residue number in PDB)		I23 Q41 K99 G100 R102 Q103 T104 G105 F130 L132 R142 G146 S150 L151
Binding residue
(residue number reindexed from 1)		I6 Q24 K82 G83 R85 Q86 T87 G88 F113 L115 R125 G129 S133 L134
Enzymatic activity
Enzyme Commision number ?
Gene Ontology
Molecular Function
GO:0003723 RNA binding
GO:0003735 structural constituent of ribosome
GO:0005515 protein binding
GO:0070180 large ribosomal subunit rRNA binding
Biological Process
GO:0006412 translation
GO:0032543 mitochondrial translation
Cellular Component
GO:0005739 mitochondrion
GO:0005743 mitochondrial inner membrane
GO:0005761 mitochondrial ribosome
GO:0005762 mitochondrial large ribosomal subunit
GO:0005840 ribosome
GO:1990904 ribonucleoprotein complex

View graph for
Molecular Function
View graph for
Biological Process
View graph for
Cellular Component
External links
PDB RCSB:7a5i, PDBe:7a5i, PDBj:7a5i
PDBsum7a5i
PubMed33243891
UniProtQ9Y3B7|RM11_HUMAN Large ribosomal subunit protein uL11m (Gene Name=MRPL11)

[Back to BioLiP]