Structure of PDB 6gzx Chain J3 Binding Site BS01

Receptor Information
>6gzx Chain J3 (length=99) Species: 300852 (Thermus thermophilus HB8) [Search protein sequence] [Download receptor structure] [Download structure with residue number starting from 1] [View receptor structure]
KIRIKLRGFDHKTLDASAQKIVEAARRSGAQVSGPIPLPTRVRRFTVIRG
PFKHKDSREHFELRTHNRLVDIINPNRKTIEQLMTLDLPTGVEIEIKTV
Ligand information
>6gzx Chain A3 (length=1506) [Search RNA sequence] [Download ligand structure] [Download structure with residue number starting from 1] [View ligand structure]
uggagaguuugauccuggcucagggugaacgcuggcggcgugccuaagac
augcaagucgugcgggccgcgggguuuuacuccguggucagcggcggacg
ggugaguaacgcgugggugaccuacccggaagagggggacaacccgggga
aacucgggcuaaucccccauguggacccgccccuugggguguguccaaag
ggcuuugcccgcuuccggaugggcccgcgucccaucagcuaguugguggg
guaauggcccaccaaggcgacgacggguagccggucugagaggauggccg
gccacaggggcacugagacacgggccccacuccuacgggaggcagcaguu
aggaaucuuccgcaaugggcgcaagccugacggagcgacgccgcuuggag
gaagaagcccuucgggguguaaacuccugaacccgggacgaaacccccga
cgaggggacugacgguaccgggguaauagcgccggccaacuccgugccag
cagccgcgguaauacggagggcgcgagcguuacccggauucacugggcgu
aaagggcguguaggcggccuggggcgucccaugugaaagaccacggcuca
accgugggggagcgugggauacgcucaggcuagacggugggagagggugg
uggaauucccggaguagcggugaaaugcgcagauaccgggaggaacgccg
auggcgaaggcagccaccugguccacccgugacgcugaggcgcgaaagcg
uggggagcaaaccggauuagauacccggguaguccacgcccuaaacgaug
cgcgcuaggucucugggucuccugggggccgaagcuaacgcguuaagcgc
gccgccuggggaguacggccgcaaggcugaaacucaaaggaauugacggg
ggcccgcacaagcgguggagcaugugguuuaauucgaagcaacgcgaaga
accuuaccaggccuugacaugcuagggaacccgggugaaagccuggggug
ccccgcgaggggagcccuagcacaggugcugcauggccgucgucagcucg
ugccgugagguguuggguuaagucccgcaacgagcgcaacccccgccguu
aguugccagcgguucggccgggcacucuaacgggacugcccgcgaaagcg
ggaggaaggaggggacgacgucuggucagcauggcccuuacggccugggc
gacacacgugcuacaaugcccacuacaaagcgaugccacccggcaacggg
gagcuaaucgcaaaaaggugggcccaguucggauuggggucugcaacccg
accccaugaagccggaaucgcuaguaaucgcggaucagccaugccgcggu
gaauacguucccgggccuuguacacaccgcccgucacgccaugggagcgg
gcucuacccgaagucgccgggagccuacgggcaggcgccgaggguagggc
ccgugacuggggcgaagucguaacaagguagcuguaccggaaggugcggc
uggauc
.....<<<..[.(((..>>>..<<<<.<<<<<..<<<<<<<......<<<
.......<<..<<...........................>>>>......
.<<.......<<<<<<<...<<...<<.......<<.<.....<<<....
....>>>.......>>>.....<<<<.<<<<<....>>>>>.>>>>....
<.......>.......>>..>>.>>>>>>><<<..........<<<<<<<
.......>>>>>>>..........>>>..<<<<<<<<....>>>...>>>
>>.>>..<<<<............>>>>..<<<<<..>>>>>......>>>
.......<.<<<....<<<......>>>..>>>>..>.>>>>>>..<<<<
.......<<......>>......>>>>....<<<<<........<<<...
....>>>..........>>>>>......<<<<.((....<<<<<......
...)).........>>>>>.>>>>..>>>>>>>>>...........<.((
.....<<<<...<<<.<<<<<..<<<<<<<<<........<<<<<<....
.>>>>>>......>>>>>>..>>>.>>>>>.........<<...<<<<<<
<....<<<<<<<..<.<<<......>>>......>>>>>>>>........
...<<....>>.>>>>>>>..>>..........>>>...>>>>....<<<
<<<...<<...<<<<.........>>>>...>>>>>>>>..........<
<<<<<..<<<<<.<<<<...>>>>.>>>>>...<<..))>>.....>>>>
>>..>...<.......<<<<....>>>>.....>....))).].<.<<.<
<<<<<<.<<..<<<<...<<<<<<<<........<<........>>....
.......<<<.......................<<......>>.......
........................<..<<<..<<<<.<<.......<<<<
.<<<....>>>..<<<<......>>>>...>>>>......<<<...<...
.....<..............>...........>......<<<......>>
>..........>>>.......>.>.>...>>>>>>..>......>>>...
....>>>>>>>>.....<<<<........<<...<<...<<<....>>>.
..>>.....>>........>>>>.........<.<<<<<...........
.>>>>>>..........>>>>......<<<<<<..........>>>>>>.
......>>...>>>>>>>>>..>........<<...<<<<.<<<..<<.<
<<<..<<<<...<.<<<<....<<<....>>>.>>>>.>..>>>>..>>>
>.>>..>>>.>>>>....>>.........<<<<.<<<<....>>>>.>>>
>.....
Receptor-Ligand Complex Structure
Global viewLocal viewStructure summary

[Spin on] [Spin off] [Reset]
[High quality] [Low quality]
[White background] [Black background]
[Spin on] [Spin off] [Reset]
[High quality] [Low quality]
[White background] [Black background]
PDB6gzx Cryo-EM structure of the hibernating Thermus thermophilus 100S ribosome reveals a protein-mediated dimerization mechanism.
Resolution4.57 Å
Binding residue
(original residue number in PDB)		H13 D17 P37 I38 P39 P41 T42 R43 V44 R45 T48 R51 P53 F54 K55 H56 K57 D58 R60 E61 H68 R70
Binding residue
(residue number reindexed from 1)		H11 D15 P35 I36 P37 P39 T40 R41 V42 R43 T46 R49 P51 F52 K53 H54 K55 D56 R58 E59 H66 R68
Enzymatic activity
Enzyme Commision number ?
Gene Ontology
Molecular Function
GO:0000049 tRNA binding
GO:0003723 RNA binding
GO:0003735 structural constituent of ribosome
GO:0019843 rRNA binding
Biological Process
GO:0006412 translation
Cellular Component
GO:0005840 ribosome
GO:0015935 small ribosomal subunit
GO:1990904 ribonucleoprotein complex

View graph for
Molecular Function
View graph for
Biological Process
View graph for
Cellular Component
External links
PDB RCSB:6gzx, PDBe:6gzx, PDBj:6gzx
PDBsum6gzx
PubMed30301898
UniProtQ5SHN7|RS10_THET8 Small ribosomal subunit protein uS10 (Gene Name=rpsJ)

[Back to BioLiP]