Structure of PDB 6gzx Chain J2 Binding Site BS01

Receptor Information
>6gzx Chain J2 (length=122) Species: 300852 (Thermus thermophilus HB8) [Search protein sequence] [Download receptor structure] [Download structure with residue number starting from 1] [View receptor structure]
MIQPQTYLEVADNTGARKIMCIRVLKGSNAKYATVGDVIVASVKEAIPRG
AVKEGDVVKAVVVRTKKEIKRPDGSAIRFDDNAAVIINNQLEPRGTRVFG
PVARELREKGFMKIVSLAPEVL
Ligand information
>6gzx Chain A2 (length=2912) [Search RNA sequence] [Download ligand structure] [Download structure with residue number starting from 1] [View ligand structure]
ggucaagaugguaagggcccacgguggaugccucggcacccgagccgaug
aaggacguggcuaccugcgauaagccagggggagccgguagcgggcgugg
aucccuggauguccgaaugggggaacccggccggcgggaacgccggucac
cgcgcuuuuugcgcggggggaaccuggggaacugaaacaucucaguaccc
agaggagaggaaagagaaaucgacucccugaguagcggcgagcgaaaggg
gaccagccuaaaccguccggcuuguccgggcggggucguggggcccucgg
acaccgaauccccagccuagccgaagcuguugggaagcagcgccagagag
ggugaaagccccguaggcgaaagguggggggauaggugaggguacccgag
uaccccgugguucguggagccaugggggaaucugggcggaccaccgccua
aggcuaaguacuccgggugaccgauagcgcaccaguaccgugagggaaag
gugaaaagaaccccgggaggggagugaaauagagccugaaaccgugggcu
uacaagcagucacggccccgcaagggguuguggcgugccuauugaagcau
gagccggcgacucacggucgugggcgagcuuaagccguugaggcggaggc
guagggaaaccgaguccgaacagggcgcaaacggcccgcacgcgggccga
aaaguccgcggccguggacccgaaaccgggcgagcuagcccuggccaggg
ugaagcuggggugagacccaguggaggcccgaaccggugggggaugcaaa
ccccucggaugagcuggggcuaggagugaaaagcuaaccgagcccggaga
uagcugguucuccccgaaaugacuuuagggucagccucaggcgcugacug
gggccuguagagcacugauagggcuagggggcccaccagccuaccaaacc
cugucaaacuccgaagggucccagguggagccugggagugagggcgcgag
cgauaacguccgcguccgagcgcgggaacaaccgagaccgccagcuaagg
cccccaagucugggcuaagugguaaaggauguggcgccgcgaagacagcc
aggauguuggcuuagaagcagccaucauuuaaagagugcguaauagcuca
cuggucgaguggcgccgcgccgaaaaugaucggggcuuaagcccagcgcc
gaagcugcgggucugggggaugaccccaggcgguaggggagcguucccga
ugccgaugaaggccgacccgcgagggcggcuggagguaagggaagugcga
augccggcaugaguaacgauaaagagggugagaaucccucucgccguaag
cccaaggguuccuacgcaauggucgucagcguaggguuaggcgggaccua
aggugaagccgaaaggcguagccgaagggcagccgguuaauauuccggcc
cuucccgcaggugcgauggggggacgcucuaggcuagggggaccggagcc
auggacgagcccggccagaagcgcagggugggagguaggcaaauccgccu
cccaacaagcucugcgugguggggaagcccguacgggugacaaccccccg
aagccagggagccaagaaaagccucuaagcacaaccugcgggaacccgua
ccgcaaaccgacacaggugggcgggugcaagagcacucaggcgcgcggga
gaacccucgccaaggaacucugcaaguuggccccguaacuucgggagaag
gggugcucccuggggugaugagccccggggagccgcagugaacaggcucu
ggcgacuguuuaccaaaaacacagcucucugcgaacucguaagaggaggu
auagggagcgacgcuugcccggugccggaaggucaaggggaggggugcaa
gccccgaaccgaagccccggugaacggcggccguaacuauaacgguccua
agguagcgaaauuccuugucggguaaguuccgaccugcacgaaaagcgua
acgaccggagcgcugucucggcgagggacccggugaaauugaacuggccg
ugaagaugcggccuacccguggcaggacgaaaagaccccguggagcuuua
cugcagccugguguuggcucuuggucgcgccugcguaggauaggugggag
ccugugaacccccgccuccgggugggggggaggcgccggugaaauaccac
ccuggcgcggcugggggccuaacccucggauggggggacagcgcuuggcg
ggcaguuugacuggggcggucgccuccuaaaagguaacggaggcgcccaa
agguccccucaggcgggacggaaauccgccggagagcgcaaggguagaag
ggggccugacugcgaggccugcaagccgagcaggggcgaaagccgggccu
agugaaccgguggucccguguggaagggccaucgaucaacggauaaaagu
uaccccggggauaacaggcugaucucccccgagcguccacagcggcgggg
agguuuggcaccucgaugucggcucgucgcauccuggggcugaagaaggu
cccaaggguugggcuguucgcccauuaaagcggcacgcgagcuggguuca
gaacgucgugagacaguucggucucuauccgccacgggcgcaggaggcuu
gaggggggcucuuccuaguacgagaggaccggaagggacgcaccucuggu
uucccagcugucccuccaggggcauaagcuggguagccaugugcggaagg
gauaaccgcugaaagcaucuaagcgggaagcccgccccaagaugaggccu
cccacggcgucaagccgguaaggacccgggaagaccacccgguggauggg
ccggggguguaagcgccgcgaggcguugagccgaccggucccaaucgucc
gaggucuugacc
......<.......<<<<<<<<<<<.........<<.<<<<.<<<<....
..<<<<<<.[...((.>>>.....<<<<<<<..<<<))...].>>>....
.>>>>>>>...>>>....<<<....>>><<<<<<<<....>>>>>>>>.<
<<<<.......>>>>>.>>....<<<<<...................>>>
>>...........<<....>>....<<<<.....<<.....>>....>>>
>....<<<....<<<<<<<<.....>>>>>>>>......<<..<<<<...
........<.......<...<<....<<<........>>>.((......<
<<.....))>>>...>>.....>........>......>>>>...>>...
..<<<<<<<<.........>>>>>>>>......<<<<.....<<.>>>>.
.>>>......>>..>>>>..>>...............<<....>>.....
..........<<<<....>>>>..................>>>>>>>>>>
>.......<<<<<<<<<<<....>>>>>>>>>>>................
..<<<<<<....<<<<<<<<<<<<...<<<...<<.......>>...>>>
...<<....>>..<<<<.....>>>>........................
....>>>>>>>>>>>>..<<.<...<<<<<<......<<<<<<<<...<<
....<<<<<<......>>>>>>.....>>.....<<...<<<........
>>.>.>>.....>>>>>>>>......<.....>........>>>>>>...
....>>>..<<<<<<....<<<<<....>>>>><.<<<<<<<.....<<<
<<<<<<...<<<...<<<<<<<<.<.....................>.>>
>>>>>>..>>.>...>>>>>>>>>.....>>>>>.>.>>..<<<<<<<.<
<......>>.>>>>>>>......<<......>>....<<<<.<<<...<<
<(((.....<<<<..<..........<<..<<<<<<<<<........<.<
.....................................<........>...
..>.>....>>>>>>>>>.>>..........)))......>.>>>>.>>>
...>>>>>>>...<.<<<.....>>>..>......>>>>>><..<<<<..
.<<<......<<<<<.<<<....>>>>>>>>...>>>..>>>.>..>...
..>>>>>>.......<<.....<<<<.<........>>>>>.<<<....<
<<<<.<.<...<<<<<.............>>>>>.....((.<<<.<<..
.<.<...<<<....>>>...>.>...>>....<<<<........>>>>.)
)<<<<<<<<<<<.....<<<<.....<<<..<<.<.<<<<<.<<<<.<<.
........>>>>>><<<....<<<<<<...<<<<.<..........>.>>
>>........>>>>>>...>>>....<<<<....>>>>......>>>>>.
..>>>...>>>..........>>>>........>>>>>>>>>>>>>>...
>>.....<<......>>>>>>>.<<<<<....>>>>>..>>>....<<<.
...<<<<<<<<..<.........<.....<<<<<....<....>.....>
>>>><<<<<<<<<<<<.....>>>>>>>>>>>>............<<<<<
<<....<<.<........>>>..<<<<<<<......<.......>.....
..>>>>>>>...<<<.<<<..<<<<<<<..<<<...<<...<<<<<....
>>>>>...>>...>>>>>>>>..>>>>><<<<<<.......>>>>>>...
.....<...........<<<<<<.....>>>>>>.....>....>>>...
....>>>>>>>..>..>..>>>>>>>>.>>>.>>...........<<<<.
.........>>>>..<<<<<<<<.<<<..........<<<.<<.<<...<
<<<<.<<<.<.<<<.<<<<<<.............................
..................................................
.............>>>>>>...<<<<......>>>>....>>>.>.>>>.
.>>>>>..<<<<.....>>>><<<<<<...........>>>>>>..<<..
..<<<<<<...<<<<.<.......>.>>>>.....<.....((.>....>
>>>>>....<<....................>>.<<......>>.>>)).
........<<<<<<.<<..>>....>>>>>>>>...............>>
...>>>>.>.......<<<<.<.<<<<<<...<<.......>>...>>>>
>>...>>>>.>.......<.<<<.<<<<<...<<<<<<<..........>
>>>..>>>.<<<<<.....>>>>>......>>>>..>...>>>..>....
<<<<<<<....>>>.>>>>........>>>>>>>>>>>....<<<<.<..
..<<<<..<<<<<<<...............>>>>>>>.<<<<<....<.<
...<<<<<.<<<<......>>>>....>>>>>...>.>..>>>>>...<<
<....<<<<<...........>>>>.>...>>>.>>>>........>.>>
>>..<<.........>>....<<<<<<<<<.......>>>>>....<<<.
<<<<.<<<....<<<<<....>>>>>...>>>..>>>>..>>>...>>>>
.....>......
Receptor-Ligand Complex Structure
Global viewLocal viewStructure summary

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PDB6gzx Cryo-EM structure of the hibernating Thermus thermophilus 100S ribosome reveals a protein-mediated dimerization mechanism.
Resolution4.57 Å
Binding residue
(original residue number in PDB)		M1 Q5 T6 I22 K26 S28 N29 K31 Y32 K66 K67 E68 K70
Binding residue
(residue number reindexed from 1)		M1 Q5 T6 I22 K26 S28 N29 K31 Y32 K66 K67 E68 K70
Enzymatic activity
Enzyme Commision number ?
Gene Ontology
Molecular Function
GO:0003735 structural constituent of ribosome
GO:0019843 rRNA binding
GO:0070180 large ribosomal subunit rRNA binding
Biological Process
GO:0006412 translation
Cellular Component
GO:0005840 ribosome
GO:0015934 large ribosomal subunit
GO:0022625 cytosolic large ribosomal subunit
GO:1990904 ribonucleoprotein complex

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Molecular Function
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Biological Process
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Cellular Component
External links
PDB RCSB:6gzx, PDBe:6gzx, PDBj:6gzx
PDBsum6gzx
PubMed30301898
UniProtQ5SHP8|RL14_THET8 Large ribosomal subunit protein uL14 (Gene Name=rplN)

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