Structure of PDB 8spe Chain J Binding Site BS01

Receptor Information
>8spe Chain J (length=71) Species: 9606 (Homo sapiens) [Search protein sequence] [Download receptor structure] [Download structure with residue number starting from 1] [View receptor structure]
ASTKKLSESLKRIGDELDSNMELQRMIAAVDTDSPREVFFRVAADMFSDG
NFNWGRVVALFYFASKLVLKA
Ligand information
Ligand IDZN
InChIInChI=1S/Zn/q+2
InChIKeyPTFCDOFLOPIGGS-UHFFFAOYSA-N
SMILES
SoftwareSMILES
CACTVS 3.341[Zn++]
ACDLabs 10.04
OpenEye OEToolkits 1.5.0		[Zn+2]
FormulaZn
NameZINC ION
ChEMBLCHEMBL1236970
DrugBankDB14532
ZINC
PDB chain8spe Chain J Residue 201 [Download ligand structure] [Download structure with residue number starting from 1] [View ligand structure]
Receptor-Ligand Complex Structure
Global viewLocal viewStructure summary

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PDB8spe Sequence differences between BAX and BAK core domains manifest as differences in their interactions with lipids.
Resolution2.3 Å
Binding residue
(original residue number in PDB)		D84 D86
Binding residue
(residue number reindexed from 1)		D31 D33
Annotation score4
Enzymatic activity
Enzyme Commision number ?
Gene Ontology
Biological Process
GO:0042981 regulation of apoptotic process

View graph for
Biological Process
External links
PDB RCSB:8spe, PDBe:8spe, PDBj:8spe
PDBsum8spe
PubMed38088212
UniProtQ07812|BAX_HUMAN Apoptosis regulator BAX (Gene Name=BAX)

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