Structure of PDB 8r08 Chain J Binding Site BS01

Receptor Information
>8r08 Chain J (length=196) Species: 9606 (Homo sapiens) [Search protein sequence] [Download receptor structure] [Download structure with residue number starting from 1] [View receptor structure]
PEIEWWDSYIIFGITNLVEHPAQLNPPVTLGVYLTKKEQKKLRRQTRREA
QKELQEKVRLGLMPPPEPKDISQGVHISVYRVRNLSNPAKKFKIEANAGQ
LYLTGVVVLHKDVNVVVVEGGPKAQKKFKRLMLHRIKWDTNKCVLVWEGT
AKDRSFGEMKFKQCPTENMAREHFKKHGAEHYWDLALSESVLESTD
Ligand information
>8r08 Chain 6 (length=53) [Search RNA sequence] [Download ligand structure] [Download structure with residue number starting from 1] [View ligand structure]
uuggaaaagauuagcauggccccugcgcaaggaugacuucgugaagcgau
uuu
..................................................
...
Receptor-Ligand Complex Structure
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PDB8r08 Structural insights into the cross-exon to cross-intron spliceosome switch
Resolution6.1 Å
Binding residue
(original residue number in PDB)		R453 P474 K475 P554 A555 F558 K559 A562 N563
Binding residue
(residue number reindexed from 1)		R47 P68 K69 P88 A89 F92 K93 A96 N97
Enzymatic activity
Enzyme Commision number ?
Gene Ontology
Molecular Function
GO:0003723 RNA binding
GO:0005515 protein binding
GO:0042802 identical protein binding
Biological Process
GO:0000244 spliceosomal tri-snRNP complex assembly
GO:0000375 RNA splicing, via transesterification reactions
GO:0000398 mRNA splicing, via spliceosome
GO:0006397 mRNA processing
GO:0008380 RNA splicing
Cellular Component
GO:0005634 nucleus
GO:0005654 nucleoplasm
GO:0005681 spliceosomal complex
GO:0005829 cytosol
GO:0015030 Cajal body
GO:0016607 nuclear speck
GO:0032991 protein-containing complex
GO:0046540 U4/U6 x U5 tri-snRNP complex
GO:0071005 U2-type precatalytic spliceosome

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Molecular Function
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Biological Process
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Cellular Component
External links
PDB RCSB:8r08, PDBe:8r08, PDBj:8r08
PDBsum8r08
PubMed38778104
UniProtO43395|PRPF3_HUMAN U4/U6 small nuclear ribonucleoprotein Prp3 (Gene Name=PRPF3)

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