Structure of PDB 8qpb Chain J Binding Site BS01

Receptor Information

>8qpb Chain J (length=84) Species: 9606 (Homo sapiens)

LGVYLTKKEQKKLRRQTRREAQKELQEKVRLGLMPPPEPKVRISNLMRVL
GTEAVQDPTKVEAHVRAQMAKRQKAHEEANAARK

Ligand information

>8qpb Chain 4 (length=80)

agcuuugcgcaguggcaguaucguagccaaugaggucuauccgaggcgcg
auuauugcuaauugaaaacuuuucccaaua

...................<<<<<.<<<.....<<.....>>..>>>>>>
>>............................

Receptor-Ligand Complex Structure

Structure summary

• PDB: 8qpb Structural insights into the cross-exon to cross-intron spliceosome switch
• Resolution: 3.7 Å
• Binding residue (original residue number in PDB): Q445 K447 R450 R453 Q461 R465 H511 R518
• Binding residue (residue number reindexed from 1): Q10 K12 R15 R18 Q26 R30 H76 R83

Gene Ontology

Molecular Function

• GO:0003723 RNA binding
• GO:0005515 protein binding
• GO:0042802 identical protein binding

Biological Process

• GO:0000244 spliceosomal tri-snRNP complex assembly
• GO:0000375 RNA splicing, via transesterification reactions
• GO:0000398 mRNA splicing, via spliceosome
• GO:0006397 mRNA processing
• GO:0008380 RNA splicing

Cellular Component

• GO:0005634 nucleus
• GO:0005654 nucleoplasm
• GO:0005681 spliceosomal complex
• GO:0005829 cytosol
• GO:0015030 Cajal body
• GO:0016607 nuclear speck
• GO:0032991 protein-containing complex
• GO:0046540 U4/U6 x U5 tri-snRNP complex
• GO:0071005 U2-type precatalytic spliceosome

External links

• PDB: RCSB:8qpb, PDBe:8qpb, PDBj:8qpb
• PDBsum: 8qpb
• PubMed: 38778104
• UniProt: O43395|PRPF3_HUMAN U4/U6 small nuclear ribonucleoprotein Prp3 (Gene Name=PRPF3)