Structure of PDB 8q7n Chain J Binding Site BS01

Receptor Information
>8q7n Chain J (length=260) Species: 9606 (Homo sapiens) [Search protein sequence] [Download receptor structure] [Download structure with residue number starting from 1] [View receptor structure]
PEIEWWDSYIIFGITNLVEHPAQLNPPDTPVTLGVYLTKKEQKKLRRQTR
REAQKELQEKVRLGLMPPPEPKVRISNLMRVLGTEAVQDPTKVEAHVRAQ
MAKRQKAHEEANAARKLTAEQRKVKKIKKLKEDISQGVHISVYRVRNLSN
PAKKFKIEANAGQLYLTGVVVLHKDVNVVVVEGGPKAQKKFKRLMLHRIK
WDETNKCVLVWEGTAKDRSFGEMKFKQCPTENMAREHFKKHGAEHYWDLA
LSESVLESTD
Ligand information
>8q7n Chain 6 (length=78) [Search RNA sequence] [Download ligand structure] [Download structure with residue number starting from 1] [View ligand structure]
gugcucgcuucggcagcacauauacuaaaauuggaacgauacagagaaga
uuagcauggccccugcgcaaggaugaca
<<<<<.<<....>>>>>>>...............................
............................
Receptor-Ligand Complex Structure
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PDB8q7n New insights into the functions of B complex proteins revealed by cryo-EM of dimerized spliceosomes
Resolution3.1 Å
Binding residue
(original residue number in PDB)		K446 P474 K475 N480 V484 N515 R518 K519 L520 K528 F558 K559 N563 Q566 R596 R601
Binding residue
(residue number reindexed from 1)		K43 P71 K72 N77 V81 N112 R115 K116 L117 K125 F155 K156 N160 Q163 R193 R198
Enzymatic activity
Enzyme Commision number ?
Gene Ontology
Molecular Function
GO:0003723 RNA binding
GO:0005515 protein binding
GO:0042802 identical protein binding
Biological Process
GO:0000244 spliceosomal tri-snRNP complex assembly
GO:0000375 RNA splicing, via transesterification reactions
GO:0000398 mRNA splicing, via spliceosome
GO:0006397 mRNA processing
GO:0008380 RNA splicing
Cellular Component
GO:0005634 nucleus
GO:0005654 nucleoplasm
GO:0005681 spliceosomal complex
GO:0005829 cytosol
GO:0015030 Cajal body
GO:0016607 nuclear speck
GO:0032991 protein-containing complex
GO:0046540 U4/U6 x U5 tri-snRNP complex
GO:0071005 U2-type precatalytic spliceosome

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Molecular Function
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Biological Process
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Cellular Component
External links
PDB RCSB:8q7n, PDBe:8q7n, PDBj:8q7n
PDBsum8q7n
PubMed38383864
UniProtO43395|PRPF3_HUMAN U4/U6 small nuclear ribonucleoprotein Prp3 (Gene Name=PRPF3)

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