Structure of PDB 8hsg Chain J Binding Site BS01

Receptor Information
>8hsg Chain J (length=1278) Species: 300852 (Thermus thermophilus HB8) [Search protein sequence] [Download receptor structure] [Download structure with residue number starting from 1] [View receptor structure]
KKEVRKVRIALASPEKIRSWSYGEVEKPETINYRTLKPERDGLFDERIFG
PIKDTKSIVRRYRMGHIELATPAAHIWFVKDVPSKIGTLLDLSATELEQV
LYFSKYIVLDPKGAILNGVPVEKRQLLTDEEYRELRYGKQETYPLPPGVD
ALVKDGEEVVKGQELAPGVVSRLDGVALYRFASILVVKARVYPFEDDVEV
STGDRVAPGDVLADGGKVKSDVYGRVEVDLVRNVVRVVESYDIDARMGAE
AIQQLLKELDLEALEKELLEEMKHPSRARRAKARKRLEVVRAFLDSGNRP
EWMILEAVPVLPPDLRPMVQVDGGRFATSDLNDLYRRLINRNNRLKKLLA
QGAPEIIIRNEKRMLQEAVDALLDNGRRGAPVTNPGSDRPLRSLTDILSG
KQGRFRQNLLGKRVDYSGRSVIVVGPQLKLHQCGLPKRMALELFKPFLLK
KMEEKGIAPNVKAARRMLERQRDIKDEVWDALEEVIHGKVVLLNRAPTLH
RLGIQAFQPVLVEGQSIQLHPLVCEAFNADFDGDQMAVHVPLSSFAQAEA
RIQMLSAHNLLSPASGEPLAKPSRDIILGLYYITQVRKEKKGAGLEFATP
EEALAAHERGEVALNAPIKVAGRETSVGRLKYVFANPDEALLAVAHGIVD
LQDVVTVRYMGKRLETSPGRILFARIVAEAVEDEKVAWELIQLDVPQEKN
SLKDLVYQAFLRLGMEKTARLLDALKYYGFTFSTTSGITIGIDDAVIPEE
KKQYLEEADRKLLQIEQAYEMGFLTDRERYDQILQLWTETTEKVTQAVFK
NFEENYPFNPLYVMAQSGARGNPQQIRQLCGLRGLMQKPSGETFEVPVRS
SFREGLTVLEYFISSHGARKGGADTALRTADSGYLTRKLVDVTHEIVVRE
ADCGTTNYISVPLFQPDEVTRSLRLRKRADIEAGLYGRVLAREVEVLGVR
LEEGRYLSMDDVHLLIKAAEAGEIQEVPVRSPLTCQTRYGVCQKCYGYDL
SMARPVSIGEAVGIVAAQSIGEPGTQLGLPRVIELFEARRPKAKAVISEI
DGVVRIEETEEKLSVFVESEGFSKEYKLPKEARLLVKDGDYVEAGQPLTR
GAIDPHQLLEAKGPEAVERYLVEEIQKVYRAQGVKLHDKHIEIVVRQMMK
YVEVTDPGDSRLLEGQVLEKWDVEALNERLIAEGKTPVAWKPLLMGVTKS
ALSTKSWLSAASFQNTTHVLTEAAIAGKKDELIGLKENVILGRLIPAGTG
SDFVRFTQVVDQKTLKAIEEARKEAVEA
Ligand information
Receptor-Ligand Complex Structure
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PDB8hsg Structural basis of the transcription termination factor Rho engagement with transcribing RNA polymerase from Thermus thermophilus.
Resolution3.2 Å
Binding residue
(original residue number in PDB)		R486 R488 R534 N593 K610 K621 R628 A705 A1089 Y1093 Q1441
Binding residue
(residue number reindexed from 1)		R277 R279 R325 N384 K401 K412 R419 A496 A880 Y884 Q1214
Enzymatic activity
Enzyme Commision number 2.7.7.6: DNA-directed RNA polymerase.
Gene Ontology
Molecular Function
GO:0000287 magnesium ion binding
GO:0003677 DNA binding
GO:0003899 DNA-directed 5'-3' RNA polymerase activity
GO:0005515 protein binding
GO:0008270 zinc ion binding
GO:0016779 nucleotidyltransferase activity
GO:0034062 5'-3' RNA polymerase activity
GO:0046872 metal ion binding
Biological Process
GO:0006351 DNA-templated transcription
Cellular Component
GO:0000428 DNA-directed RNA polymerase complex

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Molecular Function
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Biological Process
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Cellular Component
External links
PDB RCSB:8hsg, PDBe:8hsg, PDBj:8hsg
PDBsum8hsg
PubMed36753546
UniProtQ8RQE8|RPOC_THET8 DNA-directed RNA polymerase subunit beta' (Gene Name=rpoC)

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