Structure of PDB 8fnn Chain J Binding Site BS01
Receptor Information
>8fnn Chain J (length=47) Species:
9606,11698
[
Search protein sequence
] [
Download receptor structure
] [
Download structure with residue number starting from 1
] [
View receptor structure
]
NFRVYYRDSRDPVWKGPAKLLWKGEGAVVIQDNSDIKVVPRRKAKII
Ligand information
>8fnn Chain F (length=17) [
Search DNA sequence
] [
Download ligand structure
] [
Download structure with residue number starting from 1
] [
View ligand structure
]
cgggaaaatctctagca
Receptor-Ligand Complex Structure
Global view
Local view
Structure summary
[
Spin on
] [
Spin off
] [
Reset
]
[
High quality
] [
Low quality
]
[
White background
] [
Black background
]
[
Spin on
] [
Spin off
] [
Reset
]
[
High quality
] [
Low quality
]
[
White background
] [
Black background
]
PDB
8fnn
Mechanisms of HIV-1 integrase resistance to dolutegravir and potent inhibition of drug-resistant variants.
Resolution
2.7 Å
Binding residue
(original residue number in PDB)
R228 R263
Binding residue
(residue number reindexed from 1)
R7 R42
Enzymatic activity
Enzyme Commision number
2.7.7.-
2.7.7.49
: RNA-directed DNA polymerase.
2.7.7.7
: DNA-directed DNA polymerase.
3.1.-.-
3.1.13.2
: exoribonuclease H.
3.1.26.13
: retroviral ribonuclease H.
3.4.23.16
: HIV-1 retropepsin.
Gene Ontology
Molecular Function
GO:0003676
nucleic acid binding
GO:0008270
zinc ion binding
Biological Process
GO:0015074
DNA integration
View graph for
Molecular Function
View graph for
Biological Process
External links
PDB
RCSB:8fnn
,
PDBe:8fnn
,
PDBj:8fnn
PDBsum
8fnn
PubMed
37478179
UniProt
P12497
|POL_HV1N5 Gag-Pol polyprotein (Gene Name=gag-pol);
P42166
[
Back to BioLiP
]