Structure of PDB 8dh0 Chain J Binding Site BS01

Receptor Information
>8dh0 Chain J (length=805) Species: 10760 (Escherichia phage T7) [Search protein sequence] [Download receptor structure] [Download structure with residue number starting from 1] [View receptor structure]
NTINIAKNDFSDIELAAIPFNTLADHYGERLAREQLALEHESYEMGEARF
RKMFERQLKAGEVADNAAAKPLITTLLPKMIARINDWFEEVKAKRGIKPE
AVAYITIKTTLACLTSNTTVQAVASAIGRAIEDEARFGRIRDAKHFKKNV
EEQLNKRVGHVYKKAFMQVVEADMLSKGLLGGEAWSSWHKEDSIHVGVRC
IEMLIESTGMVLAPEYAEAIATRAGALAGISPMFQPCVVPPKPWTGITGG
GYWANGRRPLALVRTHSKKALMRYEDVYMPEVYKAINIAQNTAWKINKKV
LAVANVITKWKHCPVEDIPAWKRAAAAVYRKDKARKSRRISLEFMLEQAN
KFANHKAIWFPYNMDWRGRVYAVSMFNPQGNDMTKGLLTLAKGKPIGKEG
YYWLKIHGANCAGVDKVPFPERIKFIEENHENIMACAKSPLENTWWAEQD
SPFCFLAFCFEYAGVQHHGLSYNCSLPLAFDGSCSGIQHFSAMLRDEVGG
RAVNLLPSETVQDIYGIVAKKVNEILQADAINGTDNEVVSEKVKLGTKAL
AGQWLAYGVTRSVTKRSVMTLAYGSKEFGFRQQVLEDTIQPAIDSGKGLM
FTQPNQAAGYMAKLIWESVSVTVVAAVEAMNWLKSAAKLLAAEVKDKKTG
EILRKRCAVHWVTPDGFPVWQEYKKPIQTRLNLMFLGQSEIDAHKQESGI
APNFVHSQDGSHLRKTVVWAHEKYGIESFALIHDSFGTIPADAANLFKAV
RETMVDTYESCDVLADFYDQFADQLHESQLDKMPALPAKGNLNLRDILES
DFAFA
Ligand information
Receptor-Ligand Complex Structure
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PDB8dh0 Structural basis of transcription recognition of a hydrophobic unnatural base pair by T7 RNA polymerase.
Resolution2.9 Å
Binding residue
(original residue number in PDB)		R50 R57 E63 R298 W422 R423 Y427 R632 Y639 S641 F644 G645 Q649 E652 Y739 P780 H784
Binding residue
(residue number reindexed from 1)		R49 R56 E62 R264 W366 R367 Y371 R566 Y573 S575 F578 G579 Q583 E586 Y673 P702 H706
Enzymatic activity
Enzyme Commision number 2.7.7.6: DNA-directed RNA polymerase.
Gene Ontology
Molecular Function
GO:0003677 DNA binding
GO:0003899 DNA-directed 5'-3' RNA polymerase activity
GO:0016779 nucleotidyltransferase activity
GO:0034062 5'-3' RNA polymerase activity
Biological Process
GO:0006351 DNA-templated transcription
GO:0019083 viral transcription
GO:0039695 DNA-templated viral transcription
Cellular Component
GO:0000428 DNA-directed RNA polymerase complex

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Molecular Function
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Biological Process
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Cellular Component
External links
PDB RCSB:8dh0, PDBe:8dh0, PDBj:8dh0
PDBsum8dh0
PubMed36635281
UniProtP00573|RPOL_BPT7 T7 RNA polymerase (Gene Name=1)

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