Structure of PDB 8cst Chain J Binding Site BS01

Receptor Information
>8cst Chain J (length=107) Species: 9606 (Homo sapiens) [Search protein sequence] [Download receptor structure] [Download structure with residue number starting from 1] [View receptor structure]
ATLNQMHRLGPPKRPPRKLGPTEGRPQLKGVVLCTFTRKPKKPNSANRKC
CRVRLSTGREAVCFIPGEGHTLQEHQIVLVEGGRTQDLPGVKLTVVRGKY
DCGHVQK
Ligand information
>8cst Chain A (length=888) [Search RNA sequence] [Download ligand structure] [Download structure with residue number starting from 1] [View ligand structure]
auagguuugguccuagccuuucuauuagcucuuaguaagauuacacaugc
aagcauccccguuccagugaguucacccucuaaaucaccacgaucaaaag
ggacaagcaucaagcacgcagcaaugcagcucaaaacgcuuagccuagcc
acacccccacgggaaacagcagugauuaaccuuuagcaauaaacgaaagu
uuaacuaagcuauacuaaccccaggguuggucaauuucgugccagccacc
gcggucacacgauuaacccaagucaauagaagccggcguaaagaguguuu
uagaucaaauaaagcuaaaacucaccugaguuguaaaaaacuccaguuga
cacaaaauagacuacgaaaguggcuuuaacauaucugaacacacaauagc
uaagacccaaacugggauuagauaccccacuaugcuuagcccuaaaccuc
aacaguuaaaucaacaaaacugcucgccagaacacuacgagccacagcuu
aaaacucaaaggaccuggcggugcuucauaucccucuagaggagccuguu
cuguaaucgauaaaccccgaucaaccucaccaccucuugcucagccuaua
uaccgccaucuaacccugaugaaggcuacaaaguacguuaggucaaggug
uagcccaugagguggcaagaaaugggcuacauuuucuaccccagaaaacu
acgauagcccuuaugaaacuuaagggucgaagguggauuuagcaguaaac
ugagaguagagugcuuaguugaacagggcccugaagcgcgucacccuccu
caaguauacuucaaaggacauuuaacuaaaaccccuacgcauuuauauag
aggagacaaguaaguguacuggaaagugcacuuggacg
..((((..<<<<<<.)))).<<<<<<.<<..<<<<<<<<....<<<.<<<
..<......>......<<.......<<<<.<..<<<.....>>>.>..>>
>>..<<<<....<<...<<<....>>>..>>......>>>>.<<...>>.
>>.<<<....>>>.....>>>>>>.........<<<....<<<<....>>
>>..>>>..>>.>>>>>>.....<<<<<<<<.....(((.....((.>>>
)).......)))..>>>>>..>>.>>>>>>....<<<((.....<<<<..
<<<<.....<<<<<<......<<<.<<<.<<<......>>>..>>>.>>>
.............<<....>>.>>>>>>.....>>>>...>>>>....<<
<<<<...<<...<<<<.........>>>>...>>>>>>>>..........
<.<<<<<......))..>>>>>.>.>>>.<<.......<<<<....>>>>
.....>>..>>>>>>......<<<<<<<...<<<.<<<<<..<<<<<<<<
.......<<........>>..........<<<<<<<.......<<.<<<.
.<<.<<<<.<..<<<<<.....>>>.......>>..>.>.>>>....>>>
>>>>....>>>>>>>.....>>>>>>>>.....<<<<.....>>>>....
.<....<<<<<<<.......>>>>>>>....>.....>>>>>.....<<<
<<<<.........>>>>>>>.....>>>...>>>>>>>.......<<<<<
<..<<<<<......<<<....<<.....>>...>>>.......>>>>>.>
>>>>>......<<<<<<<<<....>>>>>>>>>.....
Receptor-Ligand Complex Structure
Global viewLocal viewStructure summary

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PDB8cst Principles of mitoribosomal small subunit assembly in eukaryotes.
Resolution2.85 Å
Binding residue
(original residue number in PDB)		A31 T32 N34 Q35 R38 P42 K43 R44 R47 G54 R55 P56 Q57 L58 K59 K71 K72 N74 S75 A76 N77 R78 K79 R82 S86 G97 E98 L109 E111 G112 Q116 P119 K129 H134
Binding residue
(residue number reindexed from 1)		A1 T2 N4 Q5 R8 P12 K13 R14 R17 G24 R25 P26 Q27 L28 K29 K41 K42 N44 S45 A46 N47 R48 K49 R52 S56 G67 E68 L79 E81 G82 Q86 P89 K99 H104
Enzymatic activity
Enzyme Commision number ?
Gene Ontology
Molecular Function
GO:0003723 RNA binding
GO:0003735 structural constituent of ribosome
GO:0005515 protein binding
Biological Process
GO:0006412 translation
GO:0032543 mitochondrial translation
Cellular Component
GO:0005739 mitochondrion
GO:0005743 mitochondrial inner membrane
GO:0005761 mitochondrial ribosome
GO:0005763 mitochondrial small ribosomal subunit
GO:0005840 ribosome
GO:0015935 small ribosomal subunit
GO:1990904 ribonucleoprotein complex

View graph for
Molecular Function
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Biological Process
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Cellular Component
External links
PDB RCSB:8cst, PDBe:8cst, PDBj:8cst
PDBsum8cst
PubMed36482135
UniProtO15235|RT12_HUMAN Small ribosomal subunit protein uS12m (Gene Name=MRPS12)

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