Structure of PDB 8bc8 Chain J Binding Site BS01

Receptor Information

>8bc8 Chain J (length=263) Species: 9606 (Homo sapiens) [Search protein sequence] [Download receptor structure] [Download structure with residue number starting from 1] [View receptor structure]

GPLGSMTQTFSSKTEWRVRAISAANLHLRTNHIYVSSDDIKETGYTYILP
KNVLKKFICISDLRAQIAGYLYGVSPPDNPQVKEIRCIVMVPQWGTHQTV
HLPGQLPQHEYLKEMEPLGWIHTQPNESPQLSPQDVTTHAKIMADNPSWD
GEKTIIITCSFTPGSCTLTAYKLTPSGYEWGRQNTDKGNNPKGYLPSHYE
RVQMLLSDRFLGFFMVPAQSSWNYNFMGVRHDPNMKYELQLANPKEFYHE
VHRPSHFLNFALL

Ligand information

Ligand ID

QB6

InChI

InChI=1S/C6H8N2O3S/c7-5-3-4(12(8,10)11)1-2-6(5)9/h1-3,9H,7H2,(H2,8,10,11)

InChIKey

AVQFHKYAVVQYQO-UHFFFAOYSA-N

SMILES

Software	SMILES
OpenEye OEToolkits 3.1.0.0	c1cc(c(cc1S(=O)(=O)N)N)O
CACTVS 3.385	Nc1cc(ccc1O)[S](N)(=O)=O

Formula

C6 H8 N2 O3 S

Name

3-azanyl-4-oxidanyl-benzenesulfonamide

PDB chain

8bc8 Chain J Residue 2402 [Download ligand structure] [Download structure with residue number starting from 1] [View ligand structure]

Receptor-Ligand Complex Structure

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Structure summary

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PDB	8bc8 Conformation-dependent ligand hot spots in the spliceosomal RNA helicase BRR2.
Resolution	2.39 Å
Binding residue (original residue number in PDB)	Y2091 T2219 P2220
Binding residue (residue number reindexed from 1)	Y34 T162 P163
Annotation score	1

Enzymatic activity

Enzyme Commision number

Gene Ontology

	Molecular Function
GO:0008233	peptidase activity
GO:0008237	metallopeptidase activity

	Biological Process
GO:0000398	mRNA splicing, via spliceosome

	Cellular Component
GO:0005681	spliceosomal complex

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Cellular Component

External links

PDB	RCSB:8bc8, PDBe:8bc8, PDBj:8bc8
PDBsum	8bc8
PubMed	36974964
UniProt	Q6P2Q9\|PRP8_HUMAN Pre-mRNA-processing-splicing factor 8 (Gene Name=PRPF8)

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