Structure of PDB 7z8f Chain J Binding Site BS01

Receptor Information
>7z8f Chain J (length=379) Species: 9823 (Sus scrofa) [Search protein sequence] [Download receptor structure] [Download structure with residue number starting from 1] [View receptor structure]
EKTAVVIDLGEAFTKCGFAGETGPRCIIPSVIKKAGMPKPIKVVQYNINT
EELYSYLKEFIHILYFRHLLVNPRDRRVVVIESVLCPSHFRETLTRVLFK
YFEVPSVLLAPSHLMALLTLGINSAMVLDCGYRESLVLPIYEGIPVLNCW
GALPLGGKALHKELETQLLEQCTVDTGAAKEQSLPSVMGSIPEGVLEDIK
VRTCFVSDLTRGLKIQAAKFNIDGNTERPSPPPNVDYPLDGEKILHVLGS
IRDSVVEILFEQDNEEKSVATLILDSLMQCPIDTRKQLAENLVIIGGTSM
LPGFLHRLLAEIRYLVEKPKYKKTLGTKTFRIHTPPAKANCVAWLGGAIF
GALQDILGSRSVSKEYYNQTGRIPDWCSL
Ligand information
Ligand IDATP
InChIInChI=1S/C10H16N5O13P3/c11-8-5-9(13-2-12-8)15(3-14-5)10-7(17)6(16)4(26-10)1-25-30(21,22)28-31(23,24)27-29(18,19)20/h2-4,6-7,10,16-17H,1H2,(H,21,22)(H,23,24)(H2,11,12,13)(H2,18,19,20)/t4-,6-,7-,10-/m1/s1
InChIKeyZKHQWZAMYRWXGA-KQYNXXCUSA-N
SMILES
SoftwareSMILES
OpenEye OEToolkits 1.5.0c1nc(c2c(n1)n(cn2)C3C(C(C(O3)COP(=O)(O)OP(=O)(O)OP(=O)(O)O)O)O)N
CACTVS 3.341Nc1ncnc2n(cnc12)[CH]3O[CH](CO[P](O)(=O)O[P](O)(=O)O[P](O)(O)=O)[CH](O)[CH]3O
ACDLabs 10.04O=P(O)(O)OP(=O)(O)OP(=O)(O)OCC3OC(n2cnc1c(ncnc12)N)C(O)C3O
OpenEye OEToolkits 1.5.0c1nc(c2c(n1)n(cn2)[C@H]3[C@@H]([C@@H]([C@H](O3)CO[P@@](=O)(O)O[P@](=O)(O)OP(=O)(O)O)O)O)N
CACTVS 3.341Nc1ncnc2n(cnc12)[C@@H]3O[C@H](CO[P@](O)(=O)O[P@@](O)(=O)O[P](O)(O)=O)[C@@H](O)[C@H]3O
FormulaC10 H16 N5 O13 P3
NameADENOSINE-5'-TRIPHOSPHATE
ChEMBLCHEMBL14249
DrugBankDB00171
ZINCZINC000004261765
PDB chain7z8f Chain J Residue 800 [Download ligand structure] [Download structure with residue number starting from 1] [View ligand structure]
Receptor-Ligand Complex Structure
Global viewLocal viewStructure summary

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PDB7z8f Structure of dynein-dynactin on microtubules shows tandem adaptor binding.
Resolution20.0 Å
Binding residue
(original residue number in PDB)		G21 A23 F24 G307 G308
Binding residue
(residue number reindexed from 1)		G10 A12 F13 G296 G297
Annotation score4
Enzymatic activity
Enzyme Commision number ?
Gene Ontology
Biological Process
GO:0098958 retrograde axonal transport of mitochondrion
Cellular Component
GO:0005737 cytoplasm
GO:0005856 cytoskeleton
GO:0005869 dynactin complex
GO:1904115 axon cytoplasm

View graph for
Biological Process
View graph for
Cellular Component
External links
PDB RCSB:7z8f, PDBe:7z8f, PDBj:7z8f
PDBsum7z8f
PubMed36071160
UniProtI3LHK5|ARP10_PIG Actin-related protein 10 (Gene Name=ACTR10)

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