Structure of PDB 7xd8 Chain J Binding Site BS01

Receptor Information

>7xd8 Chain J (length=623) Species: 11060 (dengue virus type 2)

ESETPNLDIIGKRIEKIKQEHETSWHYDQDHPYKTWAYHGSYETKQTGSA
SSMVNGVVRLLTKPWDIIPMVTQMAMTDTTPFGQQRVFKEKVDTRTQEPK
EGTKKLMKITAEWLWKELGKKKTPRMCTREEFTRKVRSNAALGAIFTDEN
KWKSAREAVEDSGFWELVDKERNLHLEGKCETCVYNMMGKREKKLGEFGK
AKGSRAIWYMWLGARFLEFEALGFLNEDHWFSRENSLSGVEGEGLHKLGY
ILRDVSKKEGGAMYADDTAGWDTRITLEDLKNEEMVTNHMEGEHKKLAEA
IFKLTYQNKVVRVQRPTPRGTVMDIISRRDQRGSGQVVTYGLNTFTNMEA
QLIRQMEGEGVFKSIQHLTVTEEIAVKNWLVRVGRERLSRMAISGDDCVV
KPLDDRFASALTALNDMGKVRKDIQQWEPSRGWNDWTQVPFCSHHFHELI
MKDGRVLVVPCRNQDELIGRARISQGAGWSLRETACLGKSYAQMWSLMYF
HRRDLRLAANAICSAVPSHWVPTSRTTWSIHATHEWMTTEDMLTVWNRVW
IQENPWMEDKTPVESWEEIPYLGKREDQWCGSLIGLTSRATWAKNIQTAI
NQVRSLIGNEEYTDYMPSMKRFR

Ligand information

>7xd8 Chain K (length=12)

acgauuauaucc

............

Receptor-Ligand Complex Structure

Structure summary

• PDB: 7xd8 Structural basis of transition from initiation to elongation in de novo viral RNA-dependent RNA polymerases.
• Resolution: 2.85 Å
• Binding residue (original residue number in PDB): K402 R404 A408 K457 R472 I474 Y476 R482 N493 G511 G602 V604 W803 M804 V812 R815
• Binding residue (residue number reindexed from 1): K135 R137 A141 K190 R205 I207 Y209 R215 N226 G244 G335 V337 W536 M537 V545 R548

Enzymatic activity

• Enzyme Commision number: 3.4.21.91: flavivirin.
  3.6.1.15: nucleoside-triphosphate phosphatase.
  3.6.4.13: RNA helicase.

Gene Ontology

Molecular Function

• GO:0003968 RNA-dependent RNA polymerase activity
• GO:0005524 ATP binding

Biological Process

• GO:0039694 viral RNA genome replication

External links

• PDB: RCSB:7xd8, PDBe:7xd8, PDBj:7xd8
• PDBsum: 7xd8
• PubMed: 36577062
• UniProt: Q91H74