Structure of PDB 7w5a Chain J Binding Site BS01

Receptor Information
>7w5a Chain J (length=567) Species: 9606 (Homo sapiens) [Search protein sequence] [Download receptor structure] [Download structure with residue number starting from 1] [View receptor structure]
VKNKAPAEVQITAEQLLREAKERELELLPPPPQQKITDEEELNDYKLRKR
KTFEDNIRKNRTVISNWIKYAQWEESLKEIQRARSIYERALDVDYRNITL
WLKYAEMEMKNRQVNHARNIWDRAITTLPRVNQFWYKYTYMEEMLGNVAG
ARQVFERWMEWQPEEQAWHSYINFELRYKEVDRARTIYERFVLVHPDVKN
WIKYARFEEKHAYFAHARKVYERAVEFFGDEHMDEHLYVAFAKFEENQKE
FERVRVIYKYALDRISKQELFKNYTIFEKKFGDRRGKRRFQYEEEVKANP
HNYDAWFDYLRLVESDAEAEAVREVNVPPIQEKRHWKRYIYNYALYEELE
AKDPERTRQASLELIPHKKAKMWILYAQFEIRQKARRALGTSIGKCPKKL
FKVYIELELQLREFDREKFLEFGPENCTSWIELETILGDIDRARLAISQP
RLDMPEVLWIDFEIEQEETERTRNYRRLLQRTQHVKVIFAFELSSGKEGS
LTKCRQINKTMRNCEEKEERLMLLESFEEEFGTASDKERVDKLMEKVKKR
RKVQTDDGSDAGWEEYF
Ligand information
>7w5a Chain F (length=97) [Search RNA sequence] [Download ligand structure] [Download structure with residue number starting from 1] [View ligand structure]
gugcucgcuucggcagcacauauacuaaaauuggaacgauacagagaaga
uuagcauggccccugcgcaaggaugacacgcaaauucgugaagcguu
<<<<<.<<<..>>>>>>>>...............................
......<<...<<<.....>>>....>>...................
Receptor-Ligand Complex Structure
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PDB7w5a Mechanism of exon ligation by human spliceosome.
Resolution3.6 Å
Binding residue
(original residue number in PDB)		R236 K237 I242 K247 N275 T277 K315
Binding residue
(residue number reindexed from 1)		R58 K59 I64 K69 N97 T99 K137
Enzymatic activity
Enzyme Commision number ?
Gene Ontology
Molecular Function
GO:0003723 RNA binding
GO:0005515 protein binding
Biological Process
GO:0000245 spliceosomal complex assembly
GO:0000398 mRNA splicing, via spliceosome
GO:0006396 RNA processing
GO:0006397 mRNA processing
GO:0008380 RNA splicing
Cellular Component
GO:0000974 Prp19 complex
GO:0005634 nucleus
GO:0005654 nucleoplasm
GO:0005681 spliceosomal complex
GO:0016607 nuclear speck
GO:0071007 U2-type catalytic step 2 spliceosome
GO:0071013 catalytic step 2 spliceosome
GO:0071014 post-mRNA release spliceosomal complex

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Molecular Function
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Biological Process
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Cellular Component
External links
PDB RCSB:7w5a, PDBe:7w5a, PDBj:7w5a
PDBsum7w5a
PubMed35705093
UniProtQ9BZJ0|CRNL1_HUMAN Crooked neck-like protein 1 (Gene Name=CRNKL1)

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