Structure of PDB 7unr Chain J Binding Site BS01

Receptor Information

>7unr Chain J (length=134) Species: 208964 (Pseudomonas aeruginosa PAO1)

IKLQVKAGQANPSPPVGPALGQHGVNIMEFCKAFNAKTQGQEPGLPTPVI
ITVYSDRSFTFETKSTPAAVLLKKAAGITSGSARPNSQKVGTVTRAQLEE
IAKTKQADLTAADLDAAVRTIAGSARSMGLNVEG

Ligand information

>7unr Chain A (length=2884)

ggucaagugaagaagcgcauacgguggaugccuuggcagucagaggcgau
gaaagacgugguagccugcgaaaagcuucggggagucggcaaacagacuu
ugauccggagaucucugaaugggggaacccaccuaggauaaccuagguau
cuuguacugaauccauaggugcaagaggcgaaccaggggaacugaaacau
cuaaguacccugaggaaaagaaaucaaccgagauucccuuaguaguggcg
agcgaacggggauuagcccuuaagcuucauugauuuuagcggaacgcucu
ggaaagugcggccauagugggugauagccccguacgcgaaaggaucuuug
aagugaaaucgaguaggacggagcacgagaaacuuugucugaacaugggg
ggaccauccuccaaggcuaaauacuacugacugaccgauagugaaccagu
accgugagggaaaggcgaaaagaaccccggagaggggagugaaauagaac
cugaaaccguaugcguacaagcagugggagccuacuuguuaggugacugc
guaccuuuuguauaaugggucagcgacuuauauucaguggcaagcuuaac
cguauaggguaggcguagcgaaagcgagucuuaauagggcguuuagucgc
uggguauagacccgaaaccgggcgaucuauccaugagcagguugaagguu
agguaacacugacuggaggaccgaacccacucccguugaaaagguagggg
augacuuguggaucggagugaaaggcuaaucaagcucggagauagcuggu
ucuccucgaaagcuauuuagguagcgccucauguaucacucuggggggua
gagcacuguuucggcuagggggucaucccgacuuaccaaaccgaugcaaa
cuccgaauacccagaagugccgagcaugggagacacacggcgggugcuaa
cguccgucgugaaaagggaaacaacccagaccgccagcuaaggucccaaa
guugugguuaagugguaaacgaugugggaaggcuuagacagcuaggaggu
uggcuuagaagcagccacccuuuaaagaaagcguaauagcucacuagucg
agucggccugcgcggaagauguaacggggcucaaaccacacaccgaagcu
gcgggugucacggugacgcgguagaggagcguucuguaagccugugaagg
ugaguugagaagcuugcuggagguaucagaagugcgaaugcugacaugag
uaacgacaaugggugugaaaaacacccacgccgaaagaccaaggguuccu
gcgcaacguuaaucgacgcaggguuagucgguuccuaaggcgaggcugaa
aagcguagucgaugggaaacagguuaauauuccuguacuucugguuacug
cgauggagggacggagaaggcuaggccagcuuggcguugguuguccaagu
uuaaggugguaggcugaaaucuuagguaaauccgggguuucaaggccgag
agcugaugacgagucgucuagaugacgaagugguugaugccaugcuucca
agaaaagcuucuaagcuucagguaaccaggaaccguaccccaaaccgaca
cagguggucggguagagaauaccaaggcgcuugagagaacucgggugaag
gaacuaggcaaaauggcaccguaacuucgggagaaggugcgccggcuagg
gugaaggauuuacuccguaagcucuggcuggucgaagauaccaggccgcu
gcgacuguuuauuaaaaacacagcacucugcaaacacgaaaguggacgua
uagggugugacgccugcccggugccggaagguuaauugaugggguuagcg
caagcgaagcucuugaucgaagccccgguaaacggcggccguaacuauaa
cgguccuaagguagcgaaauuccuugucggguaaguuccgaccugcacga
auggcguaacgauggcggcgcugucuccacccgagacucagugaaauuga
aaucgcugugaagaugcaguguauccgcggcuagacggaaagaccccgug
aaccuuuacuguagcuuugcacuggacuuugagccugcuuguguaggaua
ggugggaggcuuugaagcguggacgccaguucgcguggagccauccuuga
aauaccacccuggcaugcuugagguucuaacucugguccguaauccggau
cgaggacaguguauggugggcaguuugacuggggcggucuccuccuaaag
aguaacggaggaguacgaaggugcgcucagaccggucggaaaucggucgc
agaguauaaaggcaaaagcgcgcuugacugcgagacagacacgucgagca
gguacgaaaguaggucuuagugauccggugguucuguauggaagggccau
cgcucaacggauaaaagguacuccggggauaacaggcugauaccgcccaa
gaguucauaucgacggcgguguuuggcaccucgaugucggcucaucacau
ccuggggcugaagccggucccaaggguauggcuguucgccauuuaaagug
guacgcgagcuggguuuagaacgucgugagacaguucggucccuaucugc
cguggacguuugagauuugagaggggcugcuccuaguacgagaggaccgg
aguggacgaaccucugguguuccgguugucacgccaguggcauugccggg
uagcuauguucggaaaagauaaccgcugaaagcaucuaagcgggaaacuu
gccucaagaugagaucucacugggaacuugauuccccugaagggccgucg
aagacuacgacguugauaggcuggguguguaagcguugugaggcguugag
cuaaccaguacuaauugcccgugaggcuugacca

<<<<<<<<......<<<<<<<<<<<....{[[..[[<<<<<<<[[<<...
...<<<<<<.[..(((.>>>.....<<<<<<<..<<<)))...].>>>..
...>>>>>>>...>>>....<<<....>>><<<<<<<....>>>>>>>.<
<<<<<<<<.........>>>>>>>>>.>>...<<<<<<.....<......
>......>>>>>.>.........<<....>>...<<<<<.....<<....
.>>....>>>>>...(((.....<<<<<<..<<<<<..<<<...<<<.<.
.....>.>>>((......<<<.....))>>>...>>>....>>>>>..>>
>>>>...........<<<<<<<<.........>>>>>>>>......<<<<
<..<<<<>>>>>..)))......]].>>>>>>>.]]..............
.<<....>>....]].........<<<<.....>>>>.............
}....>>>>>>>>>>>.......<<<<..<<<<<.....>>>>>..>>>>
...<.<........>.>.<<<<<<....<<<<<<<<<<<<<..<<<...<
<.....>>...>>>...<<....>>..<<<<.....>>>>.....>>>>>
>>>>>>>>..<<.<...<<<<<<.....<<<<<<<<<..<<<....<<<<
<<......>>>>>>.....>>>...<<<.<<.<<........>>.>>>>>
....>>>>>>>>>...<<<.....>>>......>>>>>>......>.>>.
.<<<<<<....<<<<<....>>>>>.<<<<<<<<..<<<<<<<<<.....
<<<...<<<.<<<<...<<.<<<.......>>>..>>...>>>>.>>>..
>>.>.....>>>>>>.>>>....>>>>>>>.>...<<<<<<<<<<.....
.>>>>>>>>>>....<<<......>>>...<<<<.<<<...<<<(((...
..<<<<<<...........<<..<<<<<..<<........<<<<<.<<<.
.<<<<.......>>>>..>>>........<<<......>>>..>>>>>..
..>>..>>>>>.>>...........)))......>>>>>>.>>>...>>>
>>>><<<<<<<.>>>>>>>....>>>>>><.<<<<<...<<<......<<
<<<<<<....>>>>>>>>...>>>..>>>>>..>.....>>>>>><....
..<<.....<<<<<<.......>>>>>><<<<....<<<<<.<<...<<<
<<<...<<.....>>.>>>>>>....((<<<<<<<...<<<...<<<...
.>>>...>>>...>>>..<<<<<........>>>>>))<<<<<<<<<<<<
<...<<<<....<<<<..<<<..<<<<<<<<<<<...((((...>>>>>>
<<..<<<....<<<<<<<<<<<..<<.....>>.>>>>>>>..>>>>...
.>>>...>><..<<<<<<..>>>>>>...>>>>>>...>>>...>>>.>.
.......>>>>...>>....>>>>>>>>>>>>>>>..>>.....<<....
..>>>>>>>.<<<<.....>>>>..>>>>..<<<<....<<<<<<<<.<<
.........<.....<<<<<.....<..>......>>>>><<<<<<<<<<
<<...<<<.....>>>....>>>>>>>>>>>>............<<<<<<
<<<..<<<.........>>>..<<<<<<<.....<<<....>>>......
.>>>>>>>.<<<<<.<<<..<<<<<<<..<<<<.......<<<<<<.<<.
...>>..>>>>>>.......>>>>>>>>>..>>>>><<<<<<.......>
>>>>>........<...........<<<<<<.....>>>>>>.....>..
..>>>>>..>>.>>>>>>>..>..>>.>>>>>>>>.>>>>>>.....>..
...<<<<<........>>>>>..<<<<<<<<.(((.[[......<<<<.[
[<<<<..<<<<<.<<<.<<<<<.<<<<<<<<<<<.<.<............
<<<<...<............<<<<....>>>>.........>........
.....>>>>...>.>.>>>>>>>>>>>...<<<.<<<<<<.....>>>>>
>>>>....>>>>>.>>>..>>>>>..<<<<.....>>>><<<<<<.....
......>>>>>>..<<...<<<<<<<...<<<<<<.......>>>>>>..
...<<.[.(((>>....>>>>>>>...<<<<..<<<......>>>..>>>
>.<<<....>>>.>>)))]......<<<<<<<.((..>>>>..))>>>>>
>>.............>>>>..]]>>>>.......<<<<...<<<<<<...
<<.......>>...>>>>>>....>>>.>.......<<<<<.<<<<<<..
<<<<<<<<<......>>>>>>..>>>.<<<<<.....>>>>>.....>>>
>>..>...>>>.>>....<<<<<<<....>>>.>>>>....]]..)))>>
>>>>>>....<<<<<<<...<<<<..<<<<<<<...............>>
>>>>>.<<<<<...<<<<...<<<<<<<<<<<))))>>>>>>..>>>>>.
..>>>>.>>>>>...<<<....<<<<<...........>>>>>....>>>
.>>>>.......>>>>>>>..<<<<<.....>>>>><....<<<<<<<<<
.......>>>>>....<<<<<<<<..<<....<<<<<....>>>>>...>
>...>>>>>.>>>...>>>>..>..>>>>>>>>.

Receptor-Ligand Complex Structure

Structure summary

• PDB: 7unr Compact IF2 allows initiator tRNA accommodation into the P site and gates the ribosome to elongation
• Resolution: 2.9 Å
• Binding residue (original residue number in PDB): P75 G89 A91 P93 T118 R127 T128 G131 S132 S135
• Binding residue (residue number reindexed from 1): P67 G81 A83 P85 T110 R119 T120 G123 S124 S127

Gene Ontology

Molecular Function

• GO:0003735 structural constituent of ribosome
• GO:0019843 rRNA binding
• GO:0070180 large ribosomal subunit rRNA binding

Biological Process

• GO:0006412 translation

Cellular Component

• GO:0005840 ribosome
• GO:0022625 cytosolic large ribosomal subunit
• GO:1990904 ribonucleoprotein complex

External links

• PDB: RCSB:7unr, PDBe:7unr, PDBj:7unr
• PDBsum: 7unr
• UniProt: Q9HWC5|RL11_PSEAE Large ribosomal subunit protein uL11 (Gene Name=rplK)