Structure of PDB 7sbv Chain J Binding Site BS01

Receptor Information
>7sbv Chain J (length=1176) Species: 31631 (Human coronavirus OC43) [Search protein sequence] [Download receptor structure] [Download structure with residue number starting from 1] [View receptor structure]
VIGDLKCPLDSRTGSLNNSISTATVDVTNGLGTYYVLDRVYLNTTLFLNG
YYPTSGSTYRNMALKGTDKLSTLWFKPPFLSDFINGIFAKVKNTKVFKDG
VMYSEFPAITIGSTFVNTSYSVVVQPRTINSQGLLEVSVCQYNMCEYPHT
ICHPKLGNHFKELWHMDTGVVSCLYKRNFTYDVNATYLYFHFYQEGGTFY
AYFTDTGVVTKFLFNVYLGMALSHYYVMPLTCISRRDIGFTLEYWVTPLT
SRQYLLAFNQDGIIFNAVDCMSDFMSEIKCKTQSIAPPTGVYELNGYTVQ
PIADVYRRKPDLPNCNIEAWLNDKSVPSPLNWERKTFSNCNFNMSSLMSF
IQADSFTCNNIDAAKIYGMCFSSITIDKFAIPNGRKVDLQLGNLGYLQSF
NYRIDTTATSCQLYYNLPAANVSVSRFNPSTWNKRFGFIENSVFKPQPAG
VLTNHDVVYAQHCFKAPKNFCPCKLNSSNGIGTCPAGTNYLTCHNLCNPD
PITFTGPYKCPQTKSLVGIGEHCSGLAVKSDYCGGNPCTCQPQAFLGWSA
DSCLQGDKCNIFANLILHDVNSGLTCSTDLQKANTDIKLGVCVNYDLYGI
SGQGIFVEVNATYYNSWQNLLYDSNGNLYGFRDYITNRTFMIRSCYSGRV
SAAFHANSSEPALLFRNIKCNYVFNNSLIRQLQPINYFDSYLGCVVNAYN
STAISVQTCDLTVGSGYCVDYSTTGYRFTNFEPFTVNSVNDSLEPVGGLY
EIQIPSEFTIGNMEEFIQTSSPKVTIDCAAFVCGDYAACKSQLVEYGSFC
DNINAILTEVNELLDTTQLQVANSLMNGVTLSTKLKDGVNFNVDDINFSS
VLGSSRSAIEDLLFDKVKLSDVGFVAAYNNCTGGAEIRDLICVQSYKGIK
VLPPLLSENQISGYTLAATSASLFPPWTAAAGVPFYLNVQYRINGLGVTM
DVLSQNQKLIANAFNNALDAIQEGFDATNSALVKIQAVVNANAEALNNLL
QQLSNRFGAISSSLQEILSRLDPPEAEAQIDRLINGRLTALNAYVSQQLS
DSTLVKFSAAQAMEKVNECVKSQSSRINFCGNGNHIISLVQNAPYGLYFI
HFSYVPTKYVTAKVSPGLCIAGDRGIAPKSGYFVNVNNTWMYTGSGYYYP
EPITENNVVVMSTCAVNYTKAPYVML
Ligand information
Ligand ID8Z9
InChIInChI=1S/C16H30O2/c1-2-3-4-5-6-7-8-9-10-11-12-13-14-15-16(17)18/h10-11H,2-9,12-15H2,1H3,(H,17,18)/b11-10-
InChIKeyNNNVXFKZMRGJPM-KHPPLWFESA-N
SMILES
SoftwareSMILES
ACDLabs 12.01O=C(O)CCCC\C=C/CCCCCCCCC
OpenEye OEToolkits 2.0.7CCCCCCCCCC=CCCCCC(=O)O
CACTVS 3.385CCCCCCCCC\C=C/CCCCC(O)=O
CACTVS 3.385CCCCCCCCCC=CCCCCC(O)=O
OpenEye OEToolkits 2.0.7CCCCCCCCC/C=C\CCCCC(=O)O
FormulaC16 H30 O2
NameSapienic acid
ChEMBL
DrugBank
ZINCZINC000085617707
PDB chain7sbv Chain A Residue 1409 [Download ligand structure] [Download structure with residue number starting from 1] [View ligand structure]
Receptor-Ligand Complex Structure
Global viewLocal viewStructure summary

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PDB7sbv Structural mapping of antibody landscapes to human betacoronavirus spike proteins.
Resolution3.1 Å
Binding residue
(original residue number in PDB)		F370 M372 L375 A391 Y395 L441 L603
Binding residue
(residue number reindexed from 1)		F342 M344 L347 A363 Y367 L413 L565
Annotation score1
Enzymatic activity
Enzyme Commision number ?
Gene Ontology
Biological Process
GO:0019062 virion attachment to host cell
GO:0019064 fusion of virus membrane with host plasma membrane
GO:0039654 fusion of virus membrane with host endosome membrane
GO:0046718 symbiont entry into host cell
GO:0046813 receptor-mediated virion attachment to host cell
GO:0075509 endocytosis involved in viral entry into host cell
Cellular Component
GO:0016020 membrane
GO:0019031 viral envelope
GO:0020002 host cell plasma membrane
GO:0044173 host cell endoplasmic reticulum-Golgi intermediate compartment membrane
GO:0055036 virion membrane

View graph for
Biological Process
View graph for
Cellular Component
External links
PDB RCSB:7sbv, PDBe:7sbv, PDBj:7sbv
PDBsum7sbv
PubMed35507649
UniProtA0A0B4N7I3

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