Structure of PDB 7mj5 Chain J Binding Site BS01
Receptor Information
>7mj5 Chain J (length=257) Species:
9606
(Homo sapiens) [
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IVEGSDAEIGMSPWQVMLFRKSPQELLCGASLISDRWVLTAAHCLLYPPW
DKNFTENDLLVRIGKHSRTRYERNIEKISMLEKIYIHPRYNWRENLDRDI
ALMKLKKPVAFSDYIHPVCLPDRETAASLLQAGYKGRVTGWGNLKETWTA
NVGKGQPSVLQVVNLPIVERPVCKDSTRIRITDNMFCAGYKPDEGKRGDA
CEGDSGGPFVMKSPFNNRWYQMGIVSWGEGCDRDGKYGFYTHVFRLKKWI
QKVIDQF
Ligand information
>7mj5 Chain I (length=29) Species:
9606
(Homo sapiens) [
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GEADCGLRPLFEKKSLEDKTERELLESYI
Receptor-Ligand Complex Structure
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PDB
7mj5
Identification of a substrate-like cleavage-resistant thrombin inhibitor from the saliva of the flea Xenopsylla cheopis.
Resolution
2.15 Å
Binding residue
(original residue number in PDB)
E23 G25 M26 P28 W29 D116 H119 P120 C122 Y134 K135 R137 N159 K202 P204 R206 W207
Binding residue
(residue number reindexed from 1)
E8 G10 M11 P13 W14 D113 H116 P117 C119 Y134 K135 R137 N164 K212 P214 R218 W219
Enzymatic activity
Enzyme Commision number
3.4.21.5
: thrombin.
Gene Ontology
Molecular Function
GO:0004252
serine-type endopeptidase activity
GO:0005509
calcium ion binding
Biological Process
GO:0006508
proteolysis
GO:0007596
blood coagulation
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Molecular Function
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Biological Process
External links
PDB
RCSB:7mj5
,
PDBe:7mj5
,
PDBj:7mj5
PDBsum
7mj5
PubMed
34688666
UniProt
P00734
|THRB_HUMAN Prothrombin (Gene Name=F2)
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