Structure of PDB 7c7a Chain J Binding Site BS01

Receptor Information
>7c7a Chain J (length=292) Species: 559292 (Saccharomyces cerevisiae S288C) [Search protein sequence] [Download receptor structure] [Download structure with residue number starting from 1] [View receptor structure]
MLVDLNVPWPQNSYADKVTSQAVNNLIKTLSTLHMLGYTHIAINFTVNHS
EKFPNDVKLLNPIDIKRRFGELMDRTGLKLYSRITLIIDDPSKGQSLSKI
SQAFDIVAALPISEKGLTLSTTNLDIDLLTFQYGSRLPTFLKHKSICSCV
NRGVKLEIVYGYALRDVQARRQFVSNVRSVIRSSRSRGIVIGSGAMSPLE
CRNILGVTSLIKNLGLPSDRCSKAMGDLASLVLLNGRLRNKSHKQTIVTG
GGSGNGDDVVNDVQGIDDVQTIKVVKRSMDAEQLGHASKRHK
Ligand information
>7c7a Chain A (length=330) [Search RNA sequence] [Download ligand structure] [Download structure with residue number starting from 1] [View ligand structure]
aauccaugaccaaagaaucgucacaaaucgaagcuuacaaaauggaguaa
aauuuuguuuacucaguaauaugcuuuggguugaaagucucccaccaauu
cguaugcggaaaacguaaugagauuuaaaaaaauuguuuaaaucaacuca
uuaaggaggaugcccuuggguauucugcuucuugaccugguaccucuauu
gcaggguacugguguuuucuucgguacuggauuccguuuguauggaaucu
aaaccauaguuaugacgauugcucuuucccgugcuggaucgaguaaccca
auggagcuuacuauucuugguccauggauu
<<<<<<<<<<<<<<.<<<<<<<......<<<<<<..........<<<<<<
<......>>>>>>>........>>>>>>........[.((((.<<<....
.....<<<.....>>><<<<<..........................>>>
>><<<.<<<<<<<<....>>>>>>>>.>>>......<<<<<<<<<.....
...>>>>>>>>>..........>>>...<<<<<<<<......>>>>>>>>
.............>>>>>>><<<<..<<<......>>>..>>>>......
..)))).]...>....>>>>>>.>>>>>>>
Receptor-Ligand Complex Structure
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PDB7c7a Structural insight into precursor ribosomal RNA processing by ribonuclease MRP.
Resolution2.8 Å
Binding residue
(original residue number in PDB)		R185 R187 K223
Binding residue
(residue number reindexed from 1)		R185 R187 K223
Enzymatic activity
Enzyme Commision number 3.1.26.5: ribonuclease P.
Gene Ontology
Molecular Function
GO:0000171 ribonuclease MRP activity
GO:0003723 RNA binding
GO:0004526 ribonuclease P activity
GO:0005515 protein binding
GO:0016787 hydrolase activity
Biological Process
GO:0000294 nuclear-transcribed mRNA catabolic process, RNase MRP-dependent
GO:0000460 maturation of 5.8S rRNA
GO:0001682 tRNA 5'-leader removal
GO:0006364 rRNA processing
GO:0008033 tRNA processing
GO:0034965 intronic box C/D snoRNA processing
Cellular Component
GO:0000172 ribonuclease MRP complex
GO:0005634 nucleus
GO:0005655 nucleolar ribonuclease P complex
GO:0005829 cytosol

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Molecular Function
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Biological Process
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Cellular Component
External links
PDB RCSB:7c7a, PDBe:7c7a, PDBj:7c7a
PDBsum7c7a
PubMed32586950
UniProtP38786|RPP1_YEAST Ribonuclease P/MRP protein subunit RPP1 (Gene Name=RPP1)

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