Structure of PDB 6znn Chain J Binding Site BS01

Receptor Information
>6znn Chain J (length=379) Species: 9823 (Sus scrofa) [Search protein sequence] [Download receptor structure] [Download structure with residue number starting from 1] [View receptor structure]
EKTAVVIDLGEAFTKCGFAGETGPRCIIPSVIKKAGMPKPIKVVQYNINT
EELYSYLKEFIHILYFRHLLVNPRDRRVVVIESVLCPSHFRETLTRVLFK
YFEVPSVLLAPSHLMALLTLGINSAMVLDCGYRESLVLPIYEGIPVLNCW
GALPLGGKALHKELETQLLEQCTVDTGAAKEQSLPSVMGSIPEGVLEDIK
VRTCFVSDLTRGLKIQAAKFNIDGNTERPSPPPNVDYPLDGEKILHVLGS
IRDSVVEILFEQDNEEKSVATLILDSLMQCPIDTRKQLAENLVIIGGTSM
LPGFLHRLLAEIRYLVEKPKYKKTLGTKTFRIHTPPAKANCVAWLGGAIF
GALQDILGSRSVSKEYYNQTGRIPDWCSL
Ligand information
Ligand IDADP
InChIInChI=1S/C10H15N5O10P2/c11-8-5-9(13-2-12-8)15(3-14-5)10-7(17)6(16)4(24-10)1-23-27(21,22)25-26(18,19)20/h2-4,6-7,10,16-17H,1H2,(H,21,22)(H2,11,12,13)(H2,18,19,20)/t4-,6-,7-,10-/m1/s1
InChIKeyXTWYTFMLZFPYCI-KQYNXXCUSA-N
SMILES
SoftwareSMILES
OpenEye OEToolkits 1.5.0c1nc(c2c(n1)n(cn2)[C@H]3[C@@H]([C@@H]([C@H](O3)CO[P@](=O)(O)OP(=O)(O)O)O)O)N
CACTVS 3.341Nc1ncnc2n(cnc12)[CH]3O[CH](CO[P](O)(=O)O[P](O)(O)=O)[CH](O)[CH]3O
ACDLabs 10.04O=P(O)(O)OP(=O)(O)OCC3OC(n2cnc1c(ncnc12)N)C(O)C3O
CACTVS 3.341Nc1ncnc2n(cnc12)[C@@H]3O[C@H](CO[P@@](O)(=O)O[P](O)(O)=O)[C@@H](O)[C@H]3O
OpenEye OEToolkits 1.5.0c1nc(c2c(n1)n(cn2)C3C(C(C(O3)COP(=O)(O)OP(=O)(O)O)O)O)N
FormulaC10 H15 N5 O10 P2
NameADENOSINE-5'-DIPHOSPHATE
ChEMBLCHEMBL14830
DrugBankDB16833
ZINCZINC000012360703
PDB chain6znn Chain J Residue 800 [Download ligand structure] [Download structure with residue number starting from 1] [View ligand structure]
Receptor-Ligand Complex Structure
Global viewLocal viewStructure summary

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PDB6znn Cryo-EM reveals the complex architecture of dynactin's shoulder region and pointed end.
Resolution4.5 Å
Binding residue
(original residue number in PDB)		G21 A23 Y143 E208 K211 G308 M311 N351
Binding residue
(residue number reindexed from 1)		G10 A12 Y132 E197 K200 G297 M300 N340
Annotation score4
Enzymatic activity
Enzyme Commision number ?
Gene Ontology
Biological Process
GO:0098958 retrograde axonal transport of mitochondrion
Cellular Component
GO:0005737 cytoplasm
GO:0005856 cytoskeleton
GO:0005869 dynactin complex
GO:1904115 axon cytoplasm

View graph for
Biological Process
View graph for
Cellular Component
External links
PDB RCSB:6znn, PDBe:6znn, PDBj:6znn
PDBsum6znn
PubMed33734450
UniProtI3LHK5|ARP10_PIG Actin-related protein 10 (Gene Name=ACTR10)

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